Results 101 to 110 of about 109,633 (300)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Towards the map of quantum gravity [PDF]

, 2018
In this paper we point out some possible links between different approaches to quantum gravity and theories of the Planck scale physics. In particular, connections between Loop Quantum Gravity, Causal Dynamical Triangulations, Ho\v{r}ava-Lifshitz gravity,
Mielczarek, Jakub, Trześniewski, Tomasz
core   +2 more sources

Identifikasi Penyebab Hambatan Supply Chain Management PPDB Menggunakan Causal Loop Diagram

Jurnal Teknologi dan Bisnis, 2020
The research on supply chain management had been carried out in both manufacturing andservices companies. In practice, supply chain management also could be applied to the education sector.Several researches related to supply chain management had been carried out in universities, especially inthe process admitting new student.
Ahmad Irfangi, Fathul Aminudin Aziz, Wiwiek R. Adawiyah, Dwita Darmawati   +3 more
openaire   +2 more sources

Quantum Non-Gravity and Stellar Collapse [PDF]

, 2011
Observational indications combined with analyses of analogue and emergent gravity in condensed matter systems support the possibility that there might be two distinct energy scales related to quantum gravity: the scale that sets the onset of quantum ...
Barcelo, C., Garay, L. J., Jannes, G.
core   +5 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Decoherence in an Interacting Quantum Field Theory: The Vacuum Case

, 2010
We apply the decoherence formalism to an interacting scalar field theory. In the spirit of the decoherence literature, we consider a "system field" and an "environment field" that interact via a cubic coupling.
C. Kiefer, D. Giulini, I. S. Gradshteyn, J. F. Koksma, J. F. Koksma, J. P. Paz, Jurjen F. Koksma, L. P. Kadanoff, L. V. Keldysh, L. V. Keldysh, M. Abramowitz, M. Le Bellac, M. A. Schlosshauer, Michael G. Schmidt, N. D. Birrell, Tomislav Prokopec   +15 more
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Adaptation Behavior of Mango Farmers to Climate Change

Jurnal Manajemen & Agribisnis, 2018
The continuing climate change phenomenon causes disruption to agricultural sector including seasonal fruits such as mangoes. To anticipate the negative effects of climate change, the farmers adapt themselves in order to maintain their mango farming.
Dhany Esperanza, Gilangsari Putri, Elly Rasmikayati, Sara Qanti, Yuyun Yuwariah   +4 more
doaj   +1 more source