Results 71 to 80 of about 14,830,215 (249)

A Structured Causal Framework for Operational Risk Quantification: Bridging Subjective and Objective Uncertainty in Advanced Risk Models

Mathematics
Evaluating risk in complex systems relies heavily on human auditors whose subjective assessments can be compromised by knowledge gaps and varying interpretations.
Guy Burstein, Inon Zuckerman
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Innovation (as a Systemic Activity) and Income Inequality: Conceptual Model and Causal Mechanisms

, 2023
How does innovation as a collective (multi-actor) activity shape the distribution of income (namely income inequality) in contemporary capitalist societies?
Fragkandreas, T.
core   +1 more source

Promoting physical activity in middle-aged and older adults through digital intervention: matching message frame and recipient profile through deep reinforcement learning

Cogent Psychology
Although physical activity has a positive impact on physical and mental health, many people remain inactive. We investigated whether a two-week mobile app intervention would improve the intention to be physically active, especially when messages were ...
Patrizia Catellani, Marco Piastra
doaj   +1 more source

Causal Discovery Algorithm Based on Non-stationary Additive Noise Model [PDF]

Jisuanji gongcheng
Causal discovery aims to mine the causal relationship between variables through observed data. Most existing methods assume that the data-generation process is stationary.
HAO Zhifeng, DING Kaipei, CAI Ruichu, CHEN Wei
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Dynamic BIM Adoption Impact on Contract Cost Variance Factors Using PLS-SEM Techniques

Applied Sciences
This paper investigates the Building Information Modeling (BIM) adoption impact on the factors of Contract Cost Variance (CCV) over time. The study considers qualitative and quantitative data to identify the most common causes of CCV through pre ...
Khalid S. Al-Gahtani, Naif M. Alsanabani, Abdullah M. Alsugair, Saad I. Aljadhai, Hatim F. Alotaibi   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Epidemiological risk factors and path models for Spotty Liver Disease in Australian cage-free flocks incorporating a scratch area

Poultry Science
Spotty Liver Disease (SLD) is a major disease component in free-range and barn lay egg production systems. SLD, due to Campylobacter hepaticus or C. bilis, may cause mortality and egg production losses.A survey of 48 cage-free layer flocks under 40 weeks
Peter John Groves, Yuanshuo Karen Gao, Michael Kotiw, Pak Hei Lorcan Wong, Wendy Isabelle Muir   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source