Results 121 to 130 of about 1,021,862 (272)

Causal reasoning about epidemiological associations in conversational AI. [PDF]

Glob Epidemiol, 2023
Cox LA.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A causal approach to nonmonotonic reasoning

Artificial Intelligence, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

CausalCervixNet: convolutional neural networks with causal insight (CICNN) in cervical cancer cell classification—leveraging deep learning models for enhanced diagnostic accuracy

BMC Cancer
Cervical cancer is a significant global health issue affecting women worldwide, necessitating prompt detection and effective management. According to the World Health Organization (WHO), approximately 660,000 new cases of cervical cancer and 350,000 ...
Zahra Taghados, Zohreh Azimifar, Malihezaman Monsefi, Mojgan Akbarzadeh Jahromi   +3 more
doaj   +1 more source

Causal Reinforcement Learning for Knowledge Graph Reasoning

Applied Sciences
Knowledge graph reasoning can deduce new facts and relationships, which is an important research direction of knowledge graphs. Most of the existing methods are based on end-to-end reasoning which cannot effectively use the knowledge graph, so ...
Dezhi Li, Yunjun Lu, Jianping Wu, Wenlu Zhou, Guangjun Zeng   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

LLM-enhanced multi-causal event causality mining in financial texts

Journal of King Saud University: Computer and Information Sciences
Event causality extraction in the financial domain is crucial for understanding complex cause-effect chains behind market movements and economic events. However, traditional event relation mining often focuses on simple, single-cause links and struggles ...
Chunyu Yan
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Counterfactual Reasoning as the Missing Link Between Statistical AI and Human Cognition: A Cognitive Science Perspective

Behavioral Sciences
Text-only large language models (LLMs) used as general-purpose reasoners achieve remarkable performance on linguistic and reasoning tasks yet remain limited on intervention-sensitive and individual-level counterfactual reasoning.
Piercesare Grimaldi
doaj   +1 more source