Results 21 to 30 of about 3,961 (231)

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers

open access: yesClinical and Translational Science, Volume 14, Issue 4, Page 1272-1279, July 2021., 2021
Neuropathic pain affects ~ 6.9–10% of the general population and leads to loss of function, anxiety, depression, sleep disturbance, and impaired cognition. Here, we report the safety, tolerability, and pharmacokinetics of a voltage‐dependent and use‐dependent sodium channel blocker, vixotrigine, currently under investigation for the treatment of ...
Himanshu Naik   +4 more
wiley   +1 more source

Three‐Year Outcomes After Dorsal Root Ganglion Stimulation in the Treatment of Neuropathic Pain After Peripheral Nerve Injury of Upper and Lower Extremities

open access: yesNeuromodulation: Technology at the Neural Interface, Volume 24, Issue 4, Page 700-707, June 2021., 2021
Abstract Objectives Traumatic peripheral nerve injuries (PNI) often result in severe neuropathic pain which typically becomes chronic, is recalcitrant to common analgesics, and is associated with sleep disturbances, anxiety, and depression. Pharmacological treatments proven to be effective against neuropathic pain are not well tolerated due to side ...
Michael Kretzschmar   +2 more
wiley   +1 more source

The Tourniquet Ischemia Test in the Diagnosis of Complex Regional Pain Syndrome

open access: yesPain Practice, Volume 21, Issue 3, Page 308-315, March 2021., 2021
Abstract Background The tourniquet ischemia test (IT) is a hitherto rarely used tool for the diagnostic work‐up of patients with suspected complex regional pain syndrome (CRPS). This analysis aims to determine the sensitivity and specificity of this test, and elucidate factors that can influence the test result.
Johann Lambeck   +3 more
wiley   +1 more source

Complex regional pain syndrome

open access: yesIndian Journal of Plastic Surgery, 2011
Complex regional pain syndrome (CRPS) previously known as reflex sympathetic dystrophy is a chronic neurological disorder involving the limbs characterized by disabling pain, swelling, vasomotor instability, sudomotor abnormality, and impairment of motor
Sandeep J Sebastin
doaj   +3 more sources

Genitofemoral neuralgia : adding to the burden of chronic vulvar pain [PDF]

open access: yes, 2015
The vulva is a particularly common locus of chronic pain with neuropathic characteristics that occurs in women of any age, though most women with neuropathic type chronic vulvar pain will remain undiagnosed even following multiple physician visits. Here,
De Muynck, Martine   +2 more
core   +2 more sources

25, 50 and 75 years ago

open access: yes, 2023
ANZ Journal of Surgery, Volume 93, Issue 3, Page 466-468, March 2023.
Julian A. Smith
wiley   +1 more source

Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial

open access: yesPain, 2016
Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 ...
T. Deer   +27 more
semanticscholar   +1 more source

Complex regional pain syndrome type I: efficacy of stellate ganglion blockade [PDF]

open access: yes, 2009
PubMed ID: 19888550Background: This study was performed to evaluate the treatment of complex regional pain syndrome (CRPS) type I with stellate ganglion blockade. Materials and methods: We performed three blockades at weekly intervals in 22 patients with
Istemi Yucel   +22 more
core   +2 more sources

Intra-Venous Lidocaine to Relieve Neuropathic Pain: A Systematic Review and Meta-Analysis

open access: yesFrontiers in Neurology, 2019
Background: The prevalence of neuropathic pain is estimated to be between 7 and 10% in the general population. The efficacy of intravenous (IV) lidocaine has been studied by numerous clinical trials on patients with neuropathic pain.
Bo Zhu   +5 more
doaj   +1 more source

MRI Findings of Causalgia of the Lower Extremity Following Transsphenoidal Resection of Pituitary Tumor

open access: yesCase Reports in Neurological Medicine, 2012
Background. Causalgia is continuing pain, allodynia, or hyperalgesia after nerve injury with edema, changes in skin blood flow, or abnormal sudomotor activity.
D. Ryan Ormond   +2 more
doaj   +1 more source

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