Results 211 to 220 of about 262,504 (266)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

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Medicolegal causal analysis

Physical Medicine and Rehabilitation Clinics of North America, 2002
This article reviews basic tort law concepts, which medical evaluators should be familiar with when working in the medicolegal environment. To facilitate medicolegal causal analysis, the concept of the health claim statement or argument is proposed. We describe medicolegal causal analysis model, which should assist the medical evaluator's determination
Michel, Lacerte, Pierre, Forcier
openaire   +2 more sources

Maximal Causality Analysis

Fifth International Conference on Application of Concurrency to System Design (ACSD'05), 2006
Perfectly synchronous systems immediately react to the inputs of their environment, which may lead to so-called causality cycles between actions and their trigger conditions. Algorithms to analyze the consistency of such cycles usually extend data types by an additional value to explicitly indicate unknown values.
Klaus Schneider 0001, Jens Brandt 0001, Tobias Schüle, Thomas Tuerk   +3 more
openaire   +1 more source

The Regression Analysis of Causal Paths

Biometrics, 1959
The purpose of this presentation is to acquaint biologists and biometricians with an important tool, path analysis. This tool can be of help in dealing with complex causal networks. These often, though not always, prove amenable to common regression technics.
Turner, Malcolm E., Stevens, Charles D.
openaire   +2 more sources

Statistical Models for Causal Analysis.

Biometrics, 1994
This book provides a quick overview of statistical models commonly used in causal analyses of nonexperimental data in the social and biomedical sciences. Topics covered are simple bivariate regression multiple regression multiple classification analysis path analysis logit regression multinomial logit regression and survival models (proportional ...
Daniel Zelterman, Robert D. Retherford, Minja Kim Choe   +2 more
openaire   +1 more source