Results 101 to 110 of about 172,794 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Downward Causation without Foundations [PDF]

open access: yes, 2010
Emergence is interpreted in a non-dualist framework of thought. No metaphysical distinction between the higher and basic levels of organization is supposed, but only a duality of modes of access.
Bitbol, Michel
core  

Advances in experimental philosophy of causation

open access: yes, 2022
What is the connection between causation and responsibility? Is there a best way to theorize philosophically about causation? Which factors determine and influence what we judge to be the cause of something?

core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Liang-Kleeman Information Flow: Theory and Applications

open access: yesEntropy, 2013
Information flow, or information transfer as it may be referred to, is a fundamental notion in general physics which has wide applications in scientific disciplines.
X. San Liang
doaj   +1 more source

Causation, Chance and the Rational Significance of Supernatural Evidence [PDF]

open access: yes, 2010
Newcomb problems turn on a tension between two principles of choice: roughly, a principle sensitive to the causal features of the relevant situation, and a principle sensitive only to evidential factors.
Huw Price, Price, Huw
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Dispositional causation

open access: yesGlossa, 2018
There are a number of phenomena where an apparent animacy requirement exceptionally admits some inanimate causers as felicitous. In this paper I argue that these should be explained not by a syntactically visible animacy feature but rather by a “what-can-
Bridget Copley
doaj   +2 more sources

Causation by Ignorance.

open access: yes, 2021
Epistemic states, what an agent knows or beliefs, play a crucial role in people's moral evaluations of the agent's actions. Whether and to what extent epistemic states also influence an agent's perceived causal contribution to an outcome remains the subject of debate.
Kirfel, Lara, Lagnado, David
openaire   +1 more source

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