Results 111 to 120 of about 172,794 (317)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Metaphysics of Causation and Physics of General Relativity
Humana.Mente: Journal of Philosophical Studies, 2018 This paper aims to discuss two realist conceptions about causation in the light of the general theory of relativity (GTR). I first consider the conserved quantity of causation, which explicitly relies on the energy conservation principle.
Vincent Lam
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Causation and complications [PDF]
Indian Journal of Plastic Surgery, 2010 hese are the facts that the authors presented: 1. The patient developed his infection eight weeks after his injections. 2. Despite having an infection that required drainage, the patient had normal range of motion in his metacarpophalangeal joints. 3. The patient refused to be admitted to hospital for “surgical drainage under general anesthesia”, hence,
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Legal Ontology, Scientific Expertise and The Factual World
Journal of Social Ontology, 2016 This article analyses the role of scientific information in legal proceedings by exploring the relationship of law, science and the factual world. The article compares legal and scientific ontology, and discusses how they relate to each other.
Lena Wahlberg
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Causation of Spondylolisthesis [PDF]
The American Journal of the Medical Sciences, 1894 n ...
openaire +1 more source