Results 71 to 80 of about 144,990 (292)

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Russell and Humean Inferences

open access: yesPrincipia: An International Journal of Epistemology, 2001
Russell's The Problems of Philosophy tries to establish a new theory of induction, at the same time that Hume is there accused of an irrational/ scepticism about induction".
João Paulo Monteiro
doaj  

The Liang-Kleeman Information Flow: Theory and Applications

open access: yesEntropy, 2013
Information flow, or information transfer as it may be referred to, is a fundamental notion in general physics which has wide applications in scientific disciplines.
X. San Liang
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Dispositional causation

open access: yesGlossa, 2018
There are a number of phenomena where an apparent animacy requirement exceptionally admits some inanimate causers as felicitous. In this paper I argue that these should be explained not by a syntactically visible animacy feature but rather by a “what-can-
Bridget Copley
doaj   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Metaphysics of Causation and Physics of General Relativity

open access: yesHumana.Mente: Journal of Philosophical Studies, 2018
This paper aims to discuss two realist conceptions about causation in the light of the general theory of relativity (GTR). I first consider the conserved quantity of causation, which explicitly relies on the energy conservation principle.
Vincent Lam
doaj  

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Legal Ontology, Scientific Expertise and The Factual World

open access: yesJournal of Social Ontology, 2016
This article analyses the role of scientific information in legal proceedings by exploring the relationship of law, science and the factual world. The article compares legal and scientific ontology, and discusses how they relate to each other.
Lena Wahlberg
doaj  

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