Results 71 to 80 of about 4,607 (192)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Why Does Something Exist? The Primacy of Identity [PDF]
Journal of Interdisciplinary SciencesThis paper begins with a (surprisingly) radical interpretation of the law of identity as an assertion of the existence of identity, of self-sameness, and a brief discussion on the axiom’s relation to humanity’s claim to knowledge.
William A. Dunkley
doaj
Effectuating New Business Development in Large Firms:
Maketingu JanaruThis study is grounded in an examination of a prominent electrical appliance corporation, with the aim of proposing an innovative framework in which to evaluate integration of distinct decision-making logics, namely Causation and Effectuation, within ...
Junya Yanagi +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
隨機化試驗在教育研究中的應用 Randomized Trials: Usage in Educational Research
Journal of Research in Education Sciences, 2010 隨機化試驗是一種行之有年的研究方法，但近年來在不同社會因素的影響之下，隨機化試驗在教育界開始備受注意，並且引起多方的討論甚至爭議。本文旨在介紹隨機化試驗的內容，包括隨機分派與因果關係的建立；並介紹兩種隨機化試驗的形式，包括隨機化對照試驗與集群隨機化試驗，以及進行時考量的要點。本文並報導三個隨機化試驗的實例以供參考，從中可看出進行隨機化試驗時，因實務所需而會有或大或小的調整，最後則以綜合討論作結。本文希望能讓讀者對隨機化試驗有比較全面的初步瞭解，如日後要從事隨機化試驗時，在設計考量上能更加全面 ...
譚克平 Hak-Ping Tam
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
St Andrews Encyclopaedia of Theology, 2022 Though not linguistically prominent in Christian scripture, the theology of providence captures several recurring scriptural themes. These include the order of the cosmos, the wisdom reflected in the natural and social worlds, the direction of the ...
David Fergusson
doaj
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source