Results 171 to 180 of about 678,027 (356)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Inchoative/causative verb pairs in Tsum
, 2020 This paper describes the variety of causative constructions found in Tsum, a Tibetan language spoken in three Village Development Committees in northern Gorkha. All languages have some means of expressing an inchoative vs.
Dhakal, Dubi Nanda, Donohue, Mark
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
187 Causative animations from Ambridge, B., Doherty, L., Maitreyee, R., Tatsumi, T., Zicherman, S., Mateo-Pedro, P., Kawakami, A., Bidgood, A., Pye, C., Narasimhan, B., Arnon, I., Bekman, D., Efrati, A., Pixabaj, S.F.C, Peliz, M.M., & Mendoza, M.J,
Ben Ambridge
core
Causative and their passives in Sanskrit
, 2020 We discuss data on causative constructions and their passives in Sanskrit. Sanskrit is unusual in licensing two different causative constructions for most verbs, together with corresponding passives.
Ruppel, Antonia +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Causative constructions in Gascon
Les construccions causatives del gascó inclouen el verb causatiu factitiu hèr, el verb matriu, i un verb lèxic en infinitiu, el verb subordinat, precedit per la preposició a.
Fernández, Beatriz +2 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source