Results 221 to 230 of about 678,027 (356)

Host response signatures across sepsis aetiologies in India: a single centre observational study. [PDF]

Lancet Reg Health Southeast Asia
Biemond JJ, Earny VA, Virk H, Adukkadukkam A, Girish A, Klarenbeek AM, Peters-Sengers H, Butler JM, Mukhopadhyay C, Wiersinga WJ, van der Poll T.   +10 more
europepmc   +1 more source

Lines Left Uncrossed: The Cost of Attrition in Metastatic Triple Negative Breast Cancer. [PDF]

Cureus
Devi R N, Krishnan M P A, Shenoy PK, Menon A.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pre-eruptive Coronal Resorptions as a Clinical Feature of FAM83H-Related Amelogenesis Imperfecta: Insights from Two Brazilian Families. [PDF]

Calcif Tissue Int
Resende KK, Amorim LS, de Paula LM, Leite AF, Mazzeu JF, Yamaguti PM, Acevedo AC.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer

Clinical Cancer Research, 2018
Illja J. Diets, E. Waanders, M. Ligtenberg, Diede A G van Bladel, E. Kamping, P. Hoogerbrugge, S. Hopman, M. Olderode-Berends, E. Gerkes, D. Koolen, C. Marcelis, G. Santen, M. V. van Belzen, D. Mordaunt, Lesley Mcgregor, E. Thompson, A. Kattamis, A. Pastorczak, W. Młynarski, D. Ilencikova, Anneke Vulto- van Silfhout, T. Gardeitchik, E. D. de Bont, J. Loeffen, A. Wagner, A. Mensenkamp, R. Kuiper, N. Hoogerbrugge, M. Jongmans   +28 more
semanticscholar   +1 more source

Changing Pattern of Peritoneal Dialysis-Related Fungal Peritonitis: A 21-Year Single-Center Experience. [PDF]

Kidney Med
Yan H, Zhang H, Qian Y, Su X, Shen Y, Huang J, Ni Z, Gu L, Fang W.   +8 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Enhanced Exome Sequencing Improves the Genetic Diagnosis of Deafblindness. [PDF]

Genes (Basel)
Cifuentes GA, Diñeiro M, Huete AR, Capín R, Santiago A, Vargas AAR, Carrero D, Biscay J, López Martínez E, Aguiar B, Urbaniak M, Fernández-Vega B, Costales M, González-Aguado R, Cabanillas R, Cadiñanos J.   +15 more
europepmc   +1 more source

Cause of Consumption [PDF]

Science, 1887
openaire   +2 more sources