Results 91 to 100 of about 1,967,307 (350)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records. [PDF]

, 2014
BACKGROUND: Ischaemia in different arterial territories before acute myocardial infarction (AMI) may influence post-AMI outcomes. No studies have evaluated prospectively collected information on ischaemia and its effect on short- and long-term coronary ...
Bhaskaran, Krishnan, Denaxas, Spiros, Hemingway, Harry, Herrett, Emily, Smeeth, Liam, Timmis, Adam   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Intrinsic capacity transitions predict overall and cause-specific mortality, incident disability, and healthcare utilization

The Journal of Nutrition, Health and Aging
Objectives: To develop an intrinsic capacity (IC) score and to investigate the association between IC transition with overall and cause-specific mortality, incident disability and healthcare utilization.
An-Chun Hwang, Liang-Yu Chen, Sung-Hua Tseng, Chung-Yu Huang, Ko-Han Yen, Liang-Kung Chen, Ming-Hsien Lin, Li-Ning Peng   +7 more
doaj   +1 more source

A Non-Linear Association of High-Density Lipoprotein Cholesterol with All-Cause and Cause-Specific Mortality in Diabetic Patients

Diabetes, Metabolic Syndrome and Obesity, 2021
Yu-qin Yan,1,* Jun Chen,1,* Yu-qing Huang2 1Department of Cardiology, People’s Hospital of Shenzhen Baoan District, Shenzhen, 518100, People’s Republic of China; 2Department of Cardiology, Guangdong Provincial People’s Hospital ...
Yan Y, Chen J, Huang Y
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cause-Specific Mortality among Medicare Enrollees [PDF]

Life tables with specific causes of death, particularly when adjusted for demographic and other personal characteristics, can be important components of cost-effectiveness and other economic studies.
Alan M. Garber, Jay Bhattacharya, Thomas MaCurdy   +2 more
core  

A meta-analysis of type 1 diabetes mellitus, all-cause and cause-specific mortality [PDF]

, 2018
A meta-analysis of type 1 diabetes mellitus, all-cause and cause-specific ...
Bowen-Jones, David, Cooper, Helen, Eloho, Akata, Mabhala, Mzwandile A.   +3 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Association between advanced lung cancer inflammation index and all-cause and cause-specific mortality among asthma patients: a cohort study

Frontiers in Nutrition
BackgroundThe advanced lung cancer inflammation index (ALI), which reflects both inflammation and nutritional status, has an uncertain role in predicting outcomes for asthma patients. This study aimed to evaluate the association between ALI and mortality
Tu-Lei Tian, Xiang-Kun Qu, Hong-Bo Zhang, Cun-Cun Wang, Qing-Qing Yuan, Jing Xia, Li-Fang Cao, Kui Liu   +7 more
doaj   +1 more source