Results 101 to 110 of about 1,967,307 (350)

Mortality trends in Croatia in the first two decades of the 21st century

Geoadria, 2023
Negative demographic trends in Croatia (natural decrease, negative net migration and population aging) are increasingly influencing socio-economic development of the country.
Vera Graovac Matassi, Adriana Rogić
doaj  

Organisational downsizing, sickness absence, and mortality: 10-town prospective cohort study [PDF]

, 2004
Objective To examine whether downsizing, the reduction of personnel in organisations, is a predictor of increased sickness absence and mortality among employees.Design Prospective cohort study over 7.5 years of employees grouped into categories on the ...
Ferrie, JE, Kivimaki, M, Linna, A, Pentti, J, Vahtera, J, Virtanen, M, Virtanen, P   +6 more
core  

The Association Between Urinary Genistein Levels and Mortality Among Adults in the United States [PDF]

, 2019
BackgroundCurrent research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population ...
Marcelo, Carolyn, Marcelo, Catherine, Qayyum, Rehan, Warwick, Melissa   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Mortality among Lifelong Nonsmokers Exposed to Secondhand Smoke at Home: Cohort Data and Sensitivity Analyses [PDF]

, 2006
Evidence is growing that secondhand smoke can cause death from several diseases. The association between household exposure to secondhand smoke and disease-specific mortality was examined in two New Zealand cohorts of lifelong nonsmokers (‘‘never smokers’
Blakely, Tony, Hill, Sarah, Kawachi, Ichiro, Woodward, Alistair   +3 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Modeling of Immunosenescence and Risk of Death from Respiratory Infections: Evaluation of the Role of Antigenic Load and Population Heterogeneity [PDF]

, 2017
It is well known that efficacy of immune functions declines with age. It results in an increase of severity and duration of respiratory infections and also in dramatic growth of risk of death due to these diseases after age 65.
Barbi, Elisabetta, Caselli, Graziella, Franceschi, C., Romanyukha, A. A., Sannikova, T. E., Yashin, A. I.   +5 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Social Isolation and Mortality in Older Adults in Sweden: A Cohort Study

International Journal of Public Health
ObjectivesThis study examined the association between social isolation and mortality outcomes in a large Swedish cohort.MethodsA cohort study was conducted among 36,490 men and women aged 56–95 years based on linking the Swedish Mammography Cohort (SMC ...
Senait Wolde, Junmei Miao Jonasson
doaj   +1 more source

Oral contraceptive use and mortality after 36 years of follow-up in the Nurses\u27 Health Study: Prospective cohort study [PDF]

, 2014
Objective To determine whether use of oral contraceptives is associated with all cause and cause specific mortality. Design Prospective cohort study. Setting Nurses’ Health Study, data collected between 1976 and 2012. Population 121 701 participants were
Charlton, Brittany M, Colditz, Graham A, Hankinson, Susan E, Michels, Karin B, Missmer, Stacey A, Rich-Edwards, Janet W, Rosner, Bernard A, Speizer, Frank E   +7 more
core   +2 more sources