Results 161 to 170 of about 14,524,943 (303)

Multimodal Deep Learning for Pulmonary Nodule Detection on Chest Radiography in High-Risk Adults, With Secondary Validation for All-Cause and Cause-Specific Mortality Prediction: A Multicenter Cohort Study. [PDF]

MedComm (2020)
Li J, Xing Y, Gao X, Liu Y, Zhang L, Huang Y, Zhang P, Ye Z, Wang M, Song F.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Utility of biological aging markers for mortality risk stratification in community-dwelling older adults: insights from the Mr. OS and Ms. OS (Hong Kong) cohort. [PDF]

J Gerontol A Biol Sci Med Sci
Wu Y, Zhang T, Li S, Leung J, Kwok T.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Prognostic Value of the Kihon Checklist in Older Cardiovascular Disease Patients. [PDF]

Prog Rehabil Med
Hashimoto K, Hirashiki A, Kawamura K, Ueda I, Yoshida T, Kamihara T, Kokubo M, Shimizu A, Kagaya H.   +8 more
europepmc   +1 more source

Natural Causes [PDF]

Journal of General Internal Medicine, 2011
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

GlycA as an Effect Modifier of Protein-Mortality Associations: A Prospective Cohort Study. [PDF]

Clin Transl Sci
Wang X, Qiao Z, Tao C, Liao S, Li Z, Xu Q, Fan Y, Wang Y, Han Y, Dai X, Lu C.   +10 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

CNDP1 (CTG)₅ allele and cardiovascular events in high-risk patients: LURIC study results. [PDF]

Sci Rep
Hettler SA, Moissl A, Delgado GE, Skladny H, März W, Krämer BK, Yard BA, Kleber ME.   +7 more
europepmc   +1 more source