Explicit Mechanistic Causal Analyses or Interventional Trials Are Required for Objective, Clinical, Voice-Based Parkinson Disease Characterization. [PDF]
Little M.
europepmc +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Health hazards associated with LNG tank truck transportation accidents in China: a text-mining analysis of accident reports and risk-management implications. [PDF]
Li N, Tang Y, Zhao J.
europepmc +1 more source
[Analysis of the causes and consequences of eye burns].
M, Piuković-Plestina, R, Szekler
openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Neprilysin and Hypertension: Cause, Consequence, or Marker? [PDF]
Qaseem M, Ali S.
europepmc +1 more source
COMPARATIVE ANALYSIS OF WORLD FINANCIAL CRISES, THEIR CAUSES AND CONSEQUENCES
S.E. Yarovenko, S.U. Niyazbekova
openaire +1 more source
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Editorial: Gut microbiome-driven pathogenesis and intervention strategies in liver diseases. [PDF]
Xiang Z, Chen Y, Ji R, Wei X, Xu X.
europepmc +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source

