Results 221 to 230 of about 604,281 (278)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vivo screen for osteoclast derived osteogenic factors using non-resorptive osteoclasts in zebrafish bone. [PDF]

G3 (Bethesda)
Caetano-Lopes J, Daponte V, Urso K, Roberts RL, Warman ML, Drissi H, Charles JF, Henke K.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Continuing problem of alcohol misuse and amplified health risk behaviors. [PDF]

Trauma Surg Acute Care Open
Ellyson AM, Rivara F.
europepmc   +1 more source

Post-Traumatic Stress Disorder After Acute Cardiovascular Events: Protocol of a Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Sandhu HK, Van Wie MP, Short MB, Miller CC.   +3 more
europepmc   +1 more source

Latent class analysis of sleep-related worry and its influencing factors among shift work nurses: a cross-sectional study. [PDF]

Front Public Health
Zhang S, Cheng Z, Qiao J.
europepmc   +1 more source

Lung cancer across borders: From molecular epidemiology to precision treatment strategies. [PDF]

Ther Adv Med Oncol
García-Pardo M, Cardona AF, Loong HH, Mezquita L.   +3 more
europepmc   +1 more source

Prognostic Significance of the Modified H2FPEF Score in Patients with Severe Primary Mitral Regurgitation. [PDF]

J Cardiovasc Dev Dis
Wong HJ, Koh TS, Bai ZR, Lai J, Gao NLX, Lim BSY, Lin NHY, Teo YH, Li TYW, Panday VB, Wong RCC, Yeo TC, Poh KK, Kong WKF, Sia CH.   +14 more
europepmc   +1 more source