Results 121 to 130 of about 1,867,740 (266)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta-Analysis. [PDF]

J Int AIDS Soc
Burke RM, Sabet N, Ellis J, Rickman HM, Rangaraj A, Lawrence DS, Jarvis JN, Falconer J, Tugume L, Berhanu RH, Ford N, MacPherson P.   +11 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Multiple cause of death during the COVID-19 pandemic: a population study In Colombia and Brazil. [PDF]

Int J Public Health
Durán D, Carabali M, Bilal U, Nicolau B, Kaufman JS.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Validade das informações ocupação e causa básica em declarações de óbito de Botucatu, São Paulo

Cadernos de Saúde Pública
O objetivo deste trabalho é estudar a validade das informações sobre ocupação habitual e causa básica em declarações de óbito (DO) de moradores de Botucatu falecidos nesta cidade.
Ricardo Cordeiro, Eduardo Rommel Olivencia Peñaloza, Chrystiano Fonseca Cardoso, Daniela Barros Cortez, Eric Kakinami, Jacques José Gomes de Souza, Maria Tereza de Moraes Souza, Ricardo Augusto Fernandes, Rodrigo Fernando Guercia, Tarso Adoni   +9 more
doaj  

The acceptability of minimally invasive tissue sampling for cause of death determination in rural South Africa: A qualitative analysis. [PDF]

PLoS One
Brandt LL, Mathebula G, Mondlane ZL, Jewett S, Kahn K, Wagner RG, Price J.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Studying asphyxiation in the lab: the role of experimental evidence in cause-of-death inquiry. [PDF]

Hist Philos Life Sci
Fischer E, Jukola S.
europepmc   +1 more source