Results 141 to 150 of about 4,282,769 (355)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Clinico-pathological discrepancies in the diagnosis of causes of death in adults in Mozambique: A retrospective observational study

open access: gold, 2019
Jaume Ordï   +30 more
openalex   +2 more sources

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin [PDF]

open access: bronze, 2007
Julián Pardo   +10 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Mortality in Central and Eastern Europe

open access: yesDemographic Research, 2004
While, during several decades, unfavourable trends in mortality were quite similar in Central Europe and in the former USSR, in the most recent years, these two parts of Europe are diverging.
doaj  

Review of Infant and Child Death in a Tertiary Care Teaching Institute in Surat

open access: yesNational Journal of Community Medicine, 2017
Background: A systematic review of child Death (CDR) was required to improve the quality of neonatal health care to avoid more deaths in that particular group especially.
Rajiv Kumar Prasad   +3 more
doaj  

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