Results 151 to 160 of about 3,277,820 (267)

Lupus, a Leading Cause of Years of Potential Life Lost in Young Women: Implications for Public Health Priorities and Research Funding. [PDF]

ACR Open Rheumatol
Yen EY, Park EJ, Singh RR.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Possible Gastroenterological Causes of FUO (Fever of Unknown Origin). [PDF]

J Clin Med
Cichy O, Wojno A, Wojno A, Karwowska A, Dróżdż O, Rabczyński M, Madziarska K.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cause of Consumption [PDF]

Science, 1887
openaire   +2 more sources

Estimates of global causes of death for children and adolescents aged 5-19 in 2000-24: secondary data analysis using bayesian multinomial logistic regression.

BMJ
Eilerts-Spinelli H, Villavicencio F, Perin J, Prieto-Merino D, Wahi A, Hug L, Strong KL, Black RE, Liu L.   +8 more
europepmc   +1 more source

Multiple cause of death during the COVID-19 pandemic: a population study In Colombia and Brazil. [PDF]

Int J Public Health
Durán D, Carabali M, Bilal U, Nicolau B, Kaufman JS.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Megalodactyly.? Cause [PDF]

Proceedings of the Royal Society of Medicine, 1933
openaire   +2 more sources

Immediate and Underlying Causes of Death and Survival Rates in Aging Adults With Down Syndrome. [PDF]

J Appl Res Intellect Disabil
Hilgenkamp TIM, Oppewal A, Chien LC, Maes-Festen DAM.   +3 more
europepmc   +1 more source