Results 201 to 210 of about 167,241,951 (289)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Causes of Death among People Affected by Tuberculosis: A Cross-Sectional Study from Trivandrum, Kerala, India. [PDF]

Indian J Community Med
Robinson A, Sushan A, Shiburaj PS, Smitha Nair PG, Ajin Sam DS, Dharman K, Divakaran SD, Rakesh PS, Kangusamy B, Kathiresan J, Abdulkader RS.   +10 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Non-Surgical Causes of Death in the Emergency Department: A Five-Year Monocentric Clinicopathological Study. [PDF]

Medicina (Kaunas)
Moldoveanu AI, Orzata DM, Cozma GV, Dan RG, Mederle OA, Zara F.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Ecological Trap in the Nest: Human Hair Causes the Death of Breeding Barn Swallows (<i>Hirundo rustica</i>). [PDF]

Ecol Evol
Peng C, Yan K, Lin S, Liang W.
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Postmortem Microbiology in Forensic Diagnostics: Interpretation of Infectious Causes of Death and Emerging Applications. [PDF]

Diagnostics (Basel)
Camatti J, Bonasoni MP, Santunione AL, Cecchi R, Radheshi E, Carretto E.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Prospective systematic classification of causes of death in the course of multiple myeloma. [PDF]

Blood Cancer J
Jin JX, Besemer B, Yilmaz B, Hänel M, Fenk R, Bertsch U, Gu KJ, Hanoun C, Blau IW, Mann C, Scheid C, Schroers R, von Metzler I, Hensel M, Klein EM, Hoffmann M, Lutz C, Riesenberg H, Martens UM, Michel CS, Kunz C, Shumilov E, Gezer D, Holderried TAW, Trautmann-Grill K, Müller-Tidow C, Weisel KC, Raab MS, Salwender HJ, Goldschmidt H, Mai EK.   +30 more
europepmc   +1 more source