Results 81 to 90 of about 3,852 (253)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 2013 Caustics are captivating light patterns created by materials focusing or diverting light by refraction or refl ection. We know caustics as random side effects, appearing, for example, at the bottom of a swimming pool, or generated by many glass objects ...
Eigensatz, M. +4 more
core +3 more sources
Magnification Cross Sections for the Elliptic Umbilic Caustic Surface
Universe, 2019 In gravitational lensing, magnification cross sections characterize the probability that a light source will have magnification greater than some fixed value, which is useful in a variety of applications. The (area) cross section is known to scale as
Amir B. Aazami +2 more
doaj +1 more source
New Journal of Physics, 2020 We analyse the spatial inhomogeneities (‘spatial clustering’) in the distribution of particles accelerated by a force that changes randomly in space and time.
J Meibohm, K Gustavsson, J Bec, B Mehlig
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Impact of Caustic Ingestion on Nutritional Status: Case Report
Case Reports in GastroenterologyIntroduction: Caustic injuries remain a major public health concern. Nutritional status plays a pivotal role in determining the outcome. Unfortunately, nutritional care guidelines are not widely implemented in clinical practice, and decisions are often ...
Gašper Razinger, Nada Rotovnik Kozjek
doaj +1 more source
, 1988 The behavior at caustics is analyzed for weakly nonlinear wave solutions of hyperbolic equations. It is shown that short waves, weak enough to be governed by linear or weakly nonlinear geometrical optics away from caustics, are giverned by linear theoy ...
Hunter, John
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source