Results 31 to 40 of about 33,094 (123)

Acúmulo e efeitos de toxinas de dinoflagelados bênticos em organismos marinhos, e possíveis interações com plástico marinho [PDF]

open access: yes, 2021
Orientador: Prof. Dr. Luiz Laureno Mafra JuniorCoorientadores: Prof. Dr. Paulo da Cunha Lana, Prof. Dr. Leonardo Sandrini NetoTese (doutorado) - Universidade Federal do Paraná, Campus Pontal do Paraná - Centro de Estudos do MarPrograma de Pós-Graduação ...
Leite, Isabel do Prado
core   +1 more source

The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles

open access: yesBiophysical Reviews, 2021
Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc.
R. J. van der Pijl   +5 more
semanticscholar   +1 more source

The N2A region of titin has a unique structural configuration

open access: yesThe Journal of General Physiology, 2021
Stronczek et al. analyze the structure of the titin-N2A poly-Ig segment, a key signaling element in the sarcomere. They reveal a unique topography for the I81-I83 tandem, but they could not confirm the presence of Ca2+ binding sites in I81-I83 or the ...
Chiara Stronczek   +6 more
semanticscholar   +1 more source

‘What You See is All There is’: The Importance of Heuristics in Cost-Benefit Analysis (CBA) and Social Return on Investment (SROI) in the Evaluation of Public Health Interventions

open access: yesApplied Health Economics and Health Policy, 2021
Health economists are currently debating, with some suspicion, the relative merits of cost-benefit analysis (CBA), grounded in theoretical welfare economics, and the proliferation of social return on investment (SROI), a pragmatic approach of developing ...
R. Edwards, C. Lawrence
semanticscholar   +1 more source

Desarrollo de métodos in vitro para la detección de biotoxinas emergentes en aguas europeas [PDF]

open access: yes, 2021
Traballo Fin de Grao en Veterinaria. Curso 2020-2021En los últimos años, el cambio climático y el exceso de gases de efecto invernadero en la atmósfera han hecho que la temperatura terrestre y oceánica haya aumentado, cambiando las características ...
Cao Cancelas, Alejandro
core  

Development of bioanalytical devices for the detection of ciguatoxins and the ciguatoxin producing genera Gambierdiscus and Fukuyoa [PDF]

open access: yes, 2022
La ciguatera (CFP) és una intoxicació alimentària que provoca símptomes gastrointestinals, cardíacs i neurològics que poden durar setmanes, mesos o fins i tot anys.
Gaiani, Greta
core  

Emerging toxins of European concern: identification, development of reference material and methods [PDF]

open access: yes, 2021
Phytoplankton is the autotrophic component of marine and freshwater ecosystems whose activity is crucial for the well-being of all the living organisms, including terrestrial and aquatic ones.
Varriale, Fabio
core  

Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases

open access: yesCells, 2020
The Mediterranean diet is associated with health benefits due to bioactive compounds such as polyphenols. The biological activities of three polyphenols (quercetin (QCT), resveratrol (RSV), apigenin (API)) were evaluated in mouse neuronal N2a cells in ...
A. Yammine   +10 more
semanticscholar   +1 more source

Synaptic Dysfunction in Prion Diseases: A Trafficking Problem?

open access: yesInternational Journal of Cell Biology, Volume 2013, Issue 1, 2013., 2013
Synaptic dysfunction is an important cause of neurological symptoms in prion diseases, a class of clinically heterogeneous neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC). Experimental data suggest that accumulation of misfolded PrPC in the endoplasmic reticulum (ER) may be crucial in synaptic failure, possibly ...
Assunta Senatore   +3 more
wiley   +1 more source

Design and Development of Degradable Polyethylenimines for Delivery of DNA and Small Interfering RNA: An Updated Review

open access: yesInternational Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Polyethylenimine (PEI), considered as the most potent and promising alternative carrier to viral vectors, has been studied as the “state of the art” among various polymers for nonviral gene delivery applications for many years. Although PEI‐based carrier minimizes the bottlenecks associated with viral vectors such as unwanted immunogenicity and ...
Chong-Su Cho, K. Hokamoto, A. O. Neto
wiley   +1 more source

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