Results 31 to 40 of about 34,725 (50)

Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study

Psychopharmacology, 2021
Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which such effects result from pharmacological versus expectancy factors.
Toni C Spinella, S. Stewart, Julia Naugler, I. Yakovenko, S. Barrett   +4 more
semanticscholar   +1 more source

Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

Journal of Clinical Medicine, 2019
Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated adverse drug events (ADEs) along with the potential for ...
Joshua D. Brown, A. Winterstein
semanticscholar   +1 more source

Radiosynthesis, In Vitro and In Vivo Evaluation of [18F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies.

ACS Chemical Neuroscience, 2021
CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [3H]CBD-2115 had a KD value of 6.9 nM and a nominal Bmax of 500 nM in 4R-tau expressing ...
Anton Lindberg, Ashley C Knight, D. Sohn, L. Rákos, J. Tong, April Radelet, N. Mason, J. Stehouwer, B. Lopresti, W. Klunk, J. Sandell, Alexander Sandberg, P. Hammarström, S. Svensson, C. Mathis, N. Vasdev   +15 more
semanticscholar   +1 more source

Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts

Cell Death and Disease, 2020
Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis.
T. Lowin, Tingting Ren, Julia Zurmahr, Tim Classen, Matthias Schneider, G. Pongratz   +5 more
semanticscholar   +1 more source

Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies

Pharmacotherapy, 2021
Cannabidiol (CBD), a non‐psychotropic phytocannabinoid from the Cannabis plant, is increasingly being pursued as a treatment for differing ailments. The bioavailability and pharmacokinetics of CBD are not well understood, and proper dosing schemes have ...
Lucy H Silmore, A. Willmer, E. Capparelli, G. Rosania   +3 more
semanticscholar   +1 more source

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

Frontiers in Immunology, 2018
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana.
J. Crippa, F. Guimarães, A. Campos, A. Zuardi   +3 more
semanticscholar   +1 more source

Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature

Toxics, 2020
Cannabidiol (CBD) is a naturally occurring, non-psychotropic cannabinoid of the hemp plant Cannabis sativa L. and has been known to induce several physiological and pharmacological effects.
P. Golombek, Marco Müller, Ines Barthlott, C. Sproll, Dirk W Lachenmeier   +4 more
semanticscholar   +1 more source

Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition

Psychopharmacology, 2019
The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC.
T. Arkell, N. Lintzeris, R. Kevin, J. Ramaekers, R. Vandrey, C. Irwin, P. Haber, I. McGregor   +7 more
semanticscholar   +1 more source

Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

Animals, 2019
Simple Summary The use of cannabidiol (CBD)-rich hemp-based nutraceuticals is increasing in dogs and cats for disorders related to anxiety, seizures, cancer and pain. To date, there is little information related to appropriate dosing or long-term effects
Kelly A. Deabold, W. Schwark, L. Wolf, J. Wakshlag   +3 more
semanticscholar   +1 more source

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

Postgraduate medicine, 2019
Context: Chronic pain is highly prevalent in most of the industrialized nations around the world. Despite the documented adverse effects, opioids are widely used for pain management.
Alex Capano, Richard Weaver, Elisa Burkman   +2 more
semanticscholar   +1 more source