Results 1 to 10 of about 17,947 (225)

Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]

Pharmaceuticals
Background/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman, Shimon Ben-Shabat, Amnon C. Sintov   +2 more
doaj   +2 more sources

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers [PDF]

Clinical and Translational Science
Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19.
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
doaj   +2 more sources

The antimicrobial potential of cannabidiol [PDF]

Communications Biology, 2021
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae.
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn   +21 more
doaj   +5 more sources

On-Line Solid Phase Extraction High Performance Liquid Chromatography Method Coupled With Tandem Mass Spectrometry for the Therapeutic Monitoring of Cannabidiol and 7-Hydroxy-cannabidiol in Human Serum and Saliva

Frontiers in Pharmacology, 2022
Cannabidiol is a novel antiseizure medication approved in Europe and the US for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex.
Valentina Franco, Valentina Franco, Michela Palmisani, Roberto Marchiselli, Francesca Crema, Cinzia Fattore, Valentina De Giorgis, Costanza Varesio, Costanza Varesio, Paola Rota, Vincenza Flora Dibari, Emilio Perucca, Emilio Perucca   +12 more
doaj   +1 more source

Formulation of Nanomicelles Loaded with Cannabidiol as a Platform for Neuroprotective Therapy

Pharmaceutics, 2022
The present study is focused on the development of cannabidiol-loaded polymeric nanomicelles as a drug delivery system with neuroprotective effects.
Yordan Yordanov, Denitsa Stefanova, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, Spiro Konstantinov, Krassimira Yoncheva   +6 more
doaj   +1 more source

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways

Frontiers in Cellular Neuroscience, 2021
The protective effect of Cannabidiol on Parkinson’s disease (PD) has been found in recent study. However, the specific mechanism of the protective effect of Cannabidiol on PD nerve damage require further exploration. This study aims to investigate effect
Shaolei Kang, Jinglin Li, Zhihui Yao, Zhihui Yao, Jiaxin Liu   +4 more
doaj   +1 more source

THERAPEUTIC POTENTIAL OF CANNABIDIOL: THE MOST IMPORTANT ACHIEVEMENTS ON THE WAY TO A NEW ERA

Медична наука України, 2023
Background. Cannabidiol (CBD), found in Cannabis sativa (hemp), is a non-psychoactive phytochemical substance that has gained considerable popularity over the past decade. Cannabidiol is the main phytocannabinoid, its share in the plant extract can reach
M.M. Shevchuk, L.I. Volos
doaj   +1 more source

Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users

Journal of Cannabis Research, 2021
Background Cannabidiol and cannabidiol-based products are proliferating in many countries. This recent and rapid diffusion prompts investigating the reasons for its use. Methods We analyzed data from an online survey among cannabidiol users in the French
Davide Fortin, Vincent Di Beo, Sophie Massin, Yann Bisiou, Patrizia Carrieri, Tangui Barré   +5 more
doaj   +1 more source

A bibliometrics and visualization analysis of cannabidiol research from 2004 to 2021

Frontiers in Pharmacology, 2022
Cannabidiol, a non-psychoactive component extracted from the plant cannabis sativa, has gained growing focus in recent years since its extensive pharmacology effects have been founded.
Liu Liu, Jianxing Liu, Ming Zhao, Meiming Cai, Fanzhang Lei, Xiaofeng Zeng, Bofeng Zhu   +6 more
doaj   +1 more source

Clinical pharmacology of cannabidiol in refractory epilepsy [PDF]

Farmacia Hospitalaria, 2020
Objective: The aim of this article is to provide a systematic and updated review on the pharmacology of cannabidiol in the context of refractory epilepsy, with special emphasis on its pharmacokinetics, adverse drug reactions and drug-drug ...
Paula Schaiquevich, Natalia Riva, Cecilia Maldonado, Marta Vázquez, Paulo Cáceres-Guido   +4 more
doaj   +1 more source