Results 1 to 10 of about 46,891 (297)

Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders [PDF]

Frontiers in Pharmacology, 2016
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues.
Regimantas Jurkus, Harriet Laura Lavinia Day, Francisco S. Guimaraes, Jonathan L C Lee, Leandro Jose Bertoglio, Carl W. Stevenson   +5 more
doaj   +8 more sources

Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]

Pharmaceuticals
Background/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman, Shimon Ben-Shabat, Amnon C. Sintov   +2 more
doaj   +2 more sources

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers [PDF]

Clinical and Translational Science
Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19.
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
doaj   +2 more sources

The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review [PDF]

Biology
Cannabidiol is a non-psychoactive compound originating from Cannabis sativa L., with a promising therapeutic profile that influences numerous cellular processes.
Mihaela Jorgovan, Tamara Maksimović, Oana Bătrîna, Codruța Șoica, Alexandra Mioc, Marius Mioc   +5 more
doaj   +2 more sources

On-Line Solid Phase Extraction High Performance Liquid Chromatography Method Coupled With Tandem Mass Spectrometry for the Therapeutic Monitoring of Cannabidiol and 7-Hydroxy-cannabidiol in Human Serum and Saliva

Frontiers in Pharmacology, 2022
Cannabidiol is a novel antiseizure medication approved in Europe and the US for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex.
Valentina Franco, Valentina Franco, Michela Palmisani, Roberto Marchiselli, Francesca Crema, Cinzia Fattore, Valentina De Giorgis, Costanza Varesio, Costanza Varesio, Paola Rota, Vincenza Flora Dibari, Emilio Perucca, Emilio Perucca   +12 more
doaj   +1 more source

Formulation of Nanomicelles Loaded with Cannabidiol as a Platform for Neuroprotective Therapy

Pharmaceutics, 2022
The present study is focused on the development of cannabidiol-loaded polymeric nanomicelles as a drug delivery system with neuroprotective effects.
Yordan Yordanov, Denitsa Stefanova, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, Spiro Konstantinov, Krassimira Yoncheva   +6 more
doaj   +1 more source

THERAPEUTIC POTENTIAL OF CANNABIDIOL: THE MOST IMPORTANT ACHIEVEMENTS ON THE WAY TO A NEW ERA

Медична наука України, 2023
Background. Cannabidiol (CBD), found in Cannabis sativa (hemp), is a non-psychoactive phytochemical substance that has gained considerable popularity over the past decade. Cannabidiol is the main phytocannabinoid, its share in the plant extract can reach
M.M. Shevchuk, L.I. Volos
doaj   +1 more source

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways

Frontiers in Cellular Neuroscience, 2021
The protective effect of Cannabidiol on Parkinson’s disease (PD) has been found in recent study. However, the specific mechanism of the protective effect of Cannabidiol on PD nerve damage require further exploration. This study aims to investigate effect
Shaolei Kang, Jinglin Li, Zhihui Yao, Zhihui Yao, Jiaxin Liu   +4 more
doaj   +1 more source

Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows. [PDF]

Int J Mol Sci
Joo J, Yang WS, Koh HJ.
europepmc   +2 more sources

Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users

Journal of Cannabis Research, 2021
Background Cannabidiol and cannabidiol-based products are proliferating in many countries. This recent and rapid diffusion prompts investigating the reasons for its use. Methods We analyzed data from an online survey among cannabidiol users in the French
Davide Fortin, Vincent Di Beo, Sophie Massin, Yann Bisiou, Patrizia Carrieri, Tangui Barré   +5 more
doaj   +1 more source