Results 31 to 40 of about 18,081 (204)

Non-linear plasma protein binding of cannabidiol

Journal of Cannabis Research
Background Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications.
Mariana Babayeva, Iva Srdanovic
doaj   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

Seminars in epileptology: Holistic management of epilepsy in adults with intellectual development disorders

Epileptic Disorders, EarlyView.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef   +10 more
wiley   +1 more source

EFFECTS OF CANNABIDIOL PLUS HYPOTHERMIA ON SHORT-TERM NEWBORN PIG BRAIN DAMAGE AFTER ACUTE HYPOXIA-ISCHEMIA

Frontiers in Neuroscience, 2016
Background: Hypothermia is standard treatment for neonatal encephalopathy, but near 50% of treated infants have adverse outcomes. Pharmacological therapies can act through complementary mechanisms to hypothermia and would improve neuroprotection ...
Hector Lafuente, Maria Ruth Pazos, Antonia de los Angeles Alvarez, Nagat Mohammed, Martin Santos, Maialen Arizti, Francisco Jose Alvarez, Jose A Martinez Orgado   +7 more
doaj   +1 more source

The Effects of Cannabidiol on the Driving Performance of Healthy Adults: A Pilot RCT

AJPM Focus, 2023
Introduction: A common side effect of cannabidiol is drowsiness, which could impact safe driving. This study's purpose was to determine the feasibility and whether cannabidiol impacts simulated driving performance.
Toni Marie Rudisill, MS, PhD, Karen (Kim) Innes, PhD, Sijin Wen, PhD, Treah Haggerty, MD, Gordon S. Smith, MB ChB   +4 more
doaj   +1 more source

Cannabidiol Prevents Heart Failure Dysfunction and Remodeling Through Preservation of Mitochondrial Function and Calcium Handling

JACC: Basic to Translational Science
Summary: Heart failure (HF) is characterized by energy deprivation, calcium (Ca2+) handling alterations, and inflammation: effects associated with mitochondrial dysfunction. Cannabidiol previously prevented mitochondrial dysfunction. Thus, it may prevent
Gerardo García-Rivas, PhD, Omar Lozano, PhD, Judith Bernal-Ramírez, PhD, Christian Silva-Platas, MSc, Felipe Salazar-Ramírez, MD, MSc, Abraham Méndez-Fernández, MSc, Carolina Morales-Ochoa, MSc, Hugo Alves-Figueiredo, PhD, Martín Rogelio Ramos-González, MD, PhD, Nestor Rubio-Infante, PhD, Eduardo Vázquez-Garza, MD, PhD, Luis A. Luévano-Martínez, PhD, Silvia López-Morán, MSc, Héctor Chapoy-Villanueva, PhD, James Bolton, MSc, José-Luis Velasco-Bolom, PhD, Paola Mendoza-Espinosa, PhD, Flavio F. Contreras-Torres, PhD, Carlos Jerjes-Sánchez, MD, Guillermo Torre-Amione, MD, PhD   +19 more
doaj   +1 more source

Disposition of a single oral dose of a cannabidiol medication in healthy cats

Frontiers in Veterinary Science, 2023
The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been for the treatment of epilepsy. Recently, the Food and Drug Administration has approved a highly purified cannabidiol medication for the add on ...
Tom Jukier, Crisanta Cruz-Espindola, Doug Martin, Dawn M. Boothe   +3 more
doaj   +1 more source

Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations

Epilepsia, EarlyView.
Abstract Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there is no loss of genetic material.
Asma Khamis, Emilia Ricci, Maria Paola Canevini, Lieven Lagae, Kentaro Tokumoto, Yushi Inoue, Tim Buckinx, Allison Watson, Kenneth A. Myers   +8 more
wiley   +1 more source

Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer

Frontiers in Pharmacology, 2019
Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and
Andrea Tomko, Lauren O’Leary, Hilary Trask, John C. Achenbach, Steven R. Hall, Steven R. Hall, Kerry B. Goralski, Kerry B. Goralski, Lee D. Ellis, Denis J. Dupré   +9 more
doaj   +1 more source

Optimal condition of cannabis maceration to obtain the high cannabidiol and Δ9-tetrahydrocannabinol content [PDF]

Anais da Academia Brasileira de Ciências, 2019
: The aim of this work was to optimize a maceration condition of cannabis (Cannabis sativa L.). A circumscribed central composite experimental design was applied in this work.
CHAOWALIT MONTON, FAMEERA MADAKA, SUKANYA SETTHARAKSA, THANIYA WUNNAKUP, JIRAPORNCHAI SUKSAEREE, THANAPAT SONGSAK   +5 more
doaj   +1 more source