Transcriptome assemblies for two drug-type cannabis chemotypes by long-read RNA sequencing. [PDF]
Plant GenomeAbstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Berkowitz O +5 more
europepmc +2 more sources
Pharmaceutics, 2023 There is potential for cannabidiol to act as an analgesic, anxiolytic and antipsychotic active ingredient; however, there is a need to find alternate administration routes to overcome its low oral bioavailability.
Zahra Khabir +5 more
doaj +1 more source
Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]
, 2019 Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II +3 more
core +2 more sources
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis
Scientific Reports, 2021 Despite the increased use of medical cannabinoids, the efficacy and safety of the treatment among children remain uncertain. The objective was to study the efficacy and safety of medical cannabinoids in children.
Nir Treves +6 more
doaj +1 more source
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model. [PDF]
, 2020 Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden unexplained death in epilepsy (SUDEP).
Anvar, Mana +3 more
core +1 more source
Passive exposure to cannabidiol oil does not cause microbiome dysbiosis in larval zebrafish
Current Research in Microbial Sciences, 2021 The use of cannabidiol oil derived products has dramatically increased in popularity and is predicted to grow steadily over the next decade. Given its relative stability, cannabidiol is likely to accumulate in the environment and affect aquatic animals ...
Maracela Talamantes +3 more
doaj +1 more source
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography [PDF]
, 2017 By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®).
Cavazzini, A +7 more
core +2 more sources
Analyzing cannabinoid-induced abnormal behavior in a zebrafish model.
PLoS ONE, 2020 In this study, we investigated locomotor activity and responses to repeated light and dark stimuli to assess cannabinoid-induced abnormal behavior in zebrafish larvae (Danio rerio), as an alternative to standard rodent models.
Akihiro Hasumi +2 more
doaj +1 more source
The Lancet Regional Health. Europe, 2023 Summary: Background: Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement established ...
Sibylle Pramhas +6 more
doaj +1 more source
Pronounced State-Level Disparities in Prescription of Cannabinoids to Medicaid Patients
Medical Cannabis and Cannabinoids, 2023 Introduction: Dronabinol is approved in the USA for chemotherapy-induced nausea as well as vomiting and HIV-induced anorexia, while cannabidiol is primarily approved for childhood epileptic disorders Lennox-Gastaut and Dravet syndrome.
Edward Y. Liu +2 more
doaj +1 more source