Results 11 to 20 of about 31,037 (228)

On-Line Solid Phase Extraction High Performance Liquid Chromatography Method Coupled With Tandem Mass Spectrometry for the Therapeutic Monitoring of Cannabidiol and 7-Hydroxy-cannabidiol in Human Serum and Saliva [PDF]

Frontiers in Pharmacology, 2022
Cannabidiol is a novel antiseizure medication approved in Europe and the US for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex.
Valentina Franco, Valentina Franco, Michela Palmisani, Roberto Marchiselli, Francesca Crema, Cinzia Fattore, Valentina De Giorgis, Costanza Varesio, Costanza Varesio, Paola Rota, Vincenza Flora Dibari, Emilio Perucca, Emilio Perucca   +12 more
doaj   +3 more sources

Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users

Journal of Cannabis Research, 2021
Background Cannabidiol and cannabidiol-based products are proliferating in many countries. This recent and rapid diffusion prompts investigating the reasons for its use. Methods We analyzed data from an online survey among cannabidiol users in the French
Davide Fortin, Vincent Di Beo, Sophie Massin, Yann Bisiou, Patrizia Carrieri, Tangui Barré   +5 more
doaj   +2 more sources

Clinical pharmacology of cannabidiol in refractory epilepsy [PDF]

Farmacia Hospitalaria, 2020
Objective: The aim of this article is to provide a systematic and updated review on the pharmacology of cannabidiol in the context of refractory epilepsy, with special emphasis on its pharmacokinetics, adverse drug reactions and drug-drug ...
Paula Schaiquevich, Natalia Riva, Cecilia Maldonado, Marta Vázquez, Paulo Cáceres-Guido   +4 more
doaj   +4 more sources

The antimicrobial potential of cannabidiol [PDF]

Communications Biology, 2021
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae.
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn   +21 more
doaj   +5 more sources

Non-linear plasma protein binding of cannabidiol

Journal of Cannabis Research
Background Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications.
Mariana Babayeva, Iva Srdanovic
doaj   +2 more sources

Formulation of Nanomicelles Loaded with Cannabidiol as a Platform for Neuroprotective Therapy

Pharmaceutics, 2022
The present study is focused on the development of cannabidiol-loaded polymeric nanomicelles as a drug delivery system with neuroprotective effects.
Yordan Yordanov, Denitsa Stefanova, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, Spiro Konstantinov, Krassimira Yoncheva   +6 more
doaj   +2 more sources

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers [PDF]

Clinical and Translational Science
Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19.
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
doaj   +2 more sources

Cannabidiol markedly alleviates skin and liver fibrosis

Frontiers in Pharmacology, 2022
Cannabidiol (CBD) has been suggested as a potential therapy for inflammatory and fibrotic diseases. Cannabidiol was demonstrated to reduce alcohol-induced liver inflammation and steatosis but its specific activity on the fibrotic process was not ...
Carmen del Río, Carmen del Río, Carmen del Río, Francisco Ruiz-Pino, María E. Prados, Bernd L. Fiebich, Manuel Tena-Sempere, Manuel Tena-Sempere, Manuel Tena-Sempere, Manuel Tena-Sempere, Eduardo Muñoz, Eduardo Muñoz, Eduardo Muñoz   +12 more
doaj   +2 more sources

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus [PDF]

Epilepsy and Behavior Case Reports, 2018
We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol.
Rajsekar R. Rajaraman, Raman Sankar, Shaun A. Hussain   +2 more
doaj   +2 more sources

EFFECTS OF CANNABIDIOL PLUS HYPOTHERMIA ON SHORT-TERM NEWBORN PIG BRAIN DAMAGE AFTER ACUTE HYPOXIA-ISCHEMIA [PDF]

Frontiers in Neuroscience, 2016
Background: Hypothermia is standard treatment for neonatal encephalopathy, but near 50% of treated infants have adverse outcomes. Pharmacological therapies can act through complementary mechanisms to hypothermia and would improve neuroprotection ...
Hector Lafuente, Maria Ruth Pazos, Antonia de los Angeles Alvarez, Nagat Mohammed, Martin Santos, Maialen Arizti, Francisco Jose Alvarez, Jose A Martinez Orgado   +7 more
doaj   +2 more sources