Results 11 to 20 of about 29,527 (256)

Cannabidiol markedly alleviates skin and liver fibrosis

Frontiers in Pharmacology, 2022
Cannabidiol (CBD) has been suggested as a potential therapy for inflammatory and fibrotic diseases. Cannabidiol was demonstrated to reduce alcohol-induced liver inflammation and steatosis but its specific activity on the fibrotic process was not ...
Carmen del Río, Carmen del Río, Carmen del Río, Francisco Ruiz-Pino, María E. Prados, Bernd L. Fiebich, Manuel Tena-Sempere, Manuel Tena-Sempere, Manuel Tena-Sempere, Manuel Tena-Sempere, Eduardo Muñoz, Eduardo Muñoz, Eduardo Muñoz   +12 more
doaj   +2 more sources

Non-linear plasma protein binding of cannabidiol

Journal of Cannabis Research
Background Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications.
Mariana Babayeva, Iva Srdanovic
doaj   +2 more sources

EFFECTS OF CANNABIDIOL PLUS HYPOTHERMIA ON SHORT-TERM NEWBORN PIG BRAIN DAMAGE AFTER ACUTE HYPOXIA-ISCHEMIA [PDF]

Frontiers in Neuroscience, 2016
Background: Hypothermia is standard treatment for neonatal encephalopathy, but near 50% of treated infants have adverse outcomes. Pharmacological therapies can act through complementary mechanisms to hypothermia and would improve neuroprotection ...
Hector Lafuente, Maria Ruth Pazos, Antonia de los Angeles Alvarez, Nagat Mohammed, Martin Santos, Maialen Arizti, Francisco Jose Alvarez, Jose A Martinez Orgado   +7 more
doaj   +2 more sources

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers [PDF]

Clinical and Translational Science
Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19.
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
doaj   +2 more sources

Todo lo que debemos saber sobre el cannabidiol [PDF]

, 2021
Dos años atrás, la madre de un paciente que padecía simultáneamente una esquizofrenia y una adicción al cannabis buscaba desesperadamente marihuana rica en Cannabidiol (CBD). Sabía que uno de los componentes del cannabis, el Tetra-hidro-cannabinol (THC),
Gual, Antoni, López Pelayo, Hugo
core   +5 more sources

Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study. [PDF]

Epilepsia Open
Abstract Objective Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC ...
Sánchez-Gamino S, Chamorro Muñoz MI, Serrano-Castro PJ, Hernández-Vitorique P, Rodríguez Jiménez L, López Moreno Y, Cabezudo-García P, García Martín G.   +7 more
europepmc   +2 more sources

The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations [PDF]

, 2020
For highly lipophilic drugs, passage into the intestinal lymphatic system rather than the portal vein following oral administration may represent a major alternative route of delivery into the general circulation.
Gershkovich, Pavel, Perucca, Emilio, Bialer, Meir, Franco, Valentina   +3 more
core   +1 more source

Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice [PDF]

, 2012
Background/Aims: Compounds of Cannabis sativa are known to exert anti-inflammatory properties, some of them without inducing psychotropic side effects. Cannabidiol (CBD) is such a side effect-free phytocannabinoid that improves chemically induced colitis
Martin Storr, Storr, Martin, Rudolf Schicho, Schicho, Rudolf   +3 more
core   +1 more source

The antimicrobial potential of cannabidiol

Communications Biology, 2021
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae.
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn   +21 more
doaj   +1 more source

CANNABIDIOL- PROVOKES OR TREATS ANXIETY DISORDERS?

European Psychiatry, 2023
Introduction After the introduction of proposal regarding cannabidiol for the treatment of some psychiatric disorders including anxiety, there is confusion if cannabidiol use is associated with the provocation of anxiety symptoms or it can be safely ...
H. Arshad, A. Arshad, M. Khalid, A. R. Khan, F. Arain, S. Khatri   +5 more
doaj   +1 more source