Results 51 to 60 of about 29,527 (256)

Disposition of a single oral dose of a cannabidiol medication in healthy cats

Frontiers in Veterinary Science, 2023
The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been for the treatment of epilepsy. Recently, the Food and Drug Administration has approved a highly purified cannabidiol medication for the add on ...
Tom Jukier, Crisanta Cruz-Espindola, Doug Martin, Dawn M. Boothe   +3 more
doaj   +1 more source

Cannabidiol Prevents Heart Failure Dysfunction and Remodeling Through Preservation of Mitochondrial Function and Calcium Handling

JACC: Basic to Translational Science
Summary: Heart failure (HF) is characterized by energy deprivation, calcium (Ca2+) handling alterations, and inflammation: effects associated with mitochondrial dysfunction. Cannabidiol previously prevented mitochondrial dysfunction. Thus, it may prevent
Gerardo García-Rivas, PhD, Omar Lozano, PhD, Judith Bernal-Ramírez, PhD, Christian Silva-Platas, MSc, Felipe Salazar-Ramírez, MD, MSc, Abraham Méndez-Fernández, MSc, Carolina Morales-Ochoa, MSc, Hugo Alves-Figueiredo, PhD, Martín Rogelio Ramos-González, MD, PhD, Nestor Rubio-Infante, PhD, Eduardo Vázquez-Garza, MD, PhD, Luis A. Luévano-Martínez, PhD, Silvia López-Morán, MSc, Héctor Chapoy-Villanueva, PhD, James Bolton, MSc, José-Luis Velasco-Bolom, PhD, Paola Mendoza-Espinosa, PhD, Flavio F. Contreras-Torres, PhD, Carlos Jerjes-Sánchez, MD, Guillermo Torre-Amione, MD, PhD   +19 more
doaj   +1 more source

The Effects of Cannabidiol on the Driving Performance of Healthy Adults: A Pilot RCT

AJPM Focus, 2023
Introduction: A common side effect of cannabidiol is drowsiness, which could impact safe driving. This study's purpose was to determine the feasibility and whether cannabidiol impacts simulated driving performance.
Toni Marie Rudisill, MS, PhD, Karen (Kim) Innes, PhD, Sijin Wen, PhD, Treah Haggerty, MD, Gordon S. Smith, MB ChB   +4 more
doaj   +1 more source

Formulation of Cannabidiol in Lipid Carriers [PDF]

, 2020
Substances extracted from Cannabis varieties are of increasing interest, especially cannabidiol as a non-psychoactive drug with various pharmacological effects. Formulation of cannabidiol is, however, challenging due to its low water solubility.
Grüne, Linda, Bunjes, Heike, Francke, Nadine   +2 more
core   +1 more source

Neuroprotection by cannabidiol and hypothermia in a piglet model of newborn hypoxic-ischemic brain damage

, 2019
Objetivo: La hipotermia, el estándar de oro después de una lesión hipóxico-isquémica, no es beneficiosa en todos los recién nacidos tratados. El cannabidiol es neuroprotector en modelos animales de encefalopatía hipóxico-isquémica neonatal.
Criado Vega, Enrique Alberto, Arruza Gómez, Luis, Ceprián Costoso, María, Aleo Luján, Esther, Martínez Orgado, José Antonio, Barata, L   +5 more
core   +2 more sources

Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer

Frontiers in Pharmacology, 2019
Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and
Andrea Tomko, Lauren O’Leary, Hilary Trask, John C. Achenbach, Steven R. Hall, Steven R. Hall, Kerry B. Goralski, Kerry B. Goralski, Lee D. Ellis, Denis J. Dupré   +9 more
doaj   +1 more source

Optimal condition of cannabis maceration to obtain the high cannabidiol and Δ9-tetrahydrocannabinol content [PDF]

Anais da Academia Brasileira de Ciências, 2019
: The aim of this work was to optimize a maceration condition of cannabis (Cannabis sativa L.). A circumscribed central composite experimental design was applied in this work.
CHAOWALIT MONTON, FAMEERA MADAKA, SUKANYA SETTHARAKSA, THANIYA WUNNAKUP, JIRAPORNCHAI SUKSAEREE, THANAPAT SONGSAK   +5 more
doaj   +1 more source

DETERMINACIÓN DE LA CAPACIDAD ANTIOXIDANTE DE UNA CREMA ELABORADA CON EXTRACTO ISOLADO DE CANNABIDIOL DE Cannabis sativa L. (CÁÑAMO)

infoANALITÍCA
En la presente investigación se determinó la capacidad antioxidante de una crema cosmética facial, elaborada a partir del extracto aislado (isolado) de cannabidiol. Para establecer la capacidad antioxidante.
Nataly Arciniegas S., Carlos Vélez, Daniela Coloma, Edison Osorio   +3 more
doaj   +1 more source

(+)-Trans-Cannabidiol Is an Agonist at Human CB₂ Receptors. [PDF]

Pharmacol Res Perspect
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Burtchaell PB, Santiago MJ, Wang C, Hagdoost M, Clay EJM, Mohnot D, Connor M.   +6 more
europepmc   +2 more sources

Efeito do canabidiol sobre a reconsolidação da memória de medo ao contexto: envolvimento dos receptores CB1 do córtex pré-límbico [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A busca por drogas que prejudicam a reconsolidação de memórias traumáticas pode ter um impacto ...
Stern, Cristina Aparecida Jark
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