Results 51 to 60 of about 31,037 (228)

Cannabidiol: extraction and purification using flow Chemistry [PDF]

, 2022
cannabinoids are of growing interest in research and pharmaceutical applications. Cannabidiol, which is a non-psychoactive cannabinoid, has many pharmaceutical applications.
Bopape, Karabo
core  

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Cannabidiol Literature Scoping Review Protocol

, 2021
The objective of this review was to systematically map the publicly available safety-related literature for cannabidiol (CBD)
Kara Franke, Allison Franzen, Daniele Wikoff, Lauren Payne, Rayetta Henderson   +4 more
core   +1 more source

Pricing Dynamics in the US Hemp Market: A Vertical Price Transmission Analysis of the Hemp Value Chain

Agribusiness, EarlyView.
ABSTRACT The US hemp market is a new and nascent industry that has been devoid of research for about half a century. This study examined the effects of exogenous shock on price at each phase of the value chain—Farm (hemp biomass), and its impact on prices at other phases of the value chain—Intermediary Processor (crude cannabidiol hemp) and Final ...
Solomon Odiase, Tyler Mark, Patalee Buddhika Appuhamilage   +2 more
wiley   +1 more source

A Rare Case of Cannabinoid Hyperemesis Syndrome Secondary to Cannabidiol for Refractory Epilepsy

, 2023
Cannabinoid hyperemesis syndrome (CHS) is associated with tetrahydrocannabinol, and rarely has been reported with cannabidiol. Cannabidiol is used in treatment-refractory epilepsy.
Katz, Daphna T., Milesi-Halle, Alessandra, Miguel Saps, Fifi, Amanda, Daphna T. Katz, Alessandra Milesi-Halle, Saps, Miguel, Amanda Fifi   +7 more
core   +1 more source

The Effects of Cannabidiol on the Driving Performance of Healthy Adults: A Pilot RCT

AJPM Focus, 2023
Introduction: A common side effect of cannabidiol is drowsiness, which could impact safe driving. This study's purpose was to determine the feasibility and whether cannabidiol impacts simulated driving performance.
Toni Marie Rudisill, MS, PhD, Karen (Kim) Innes, PhD, Sijin Wen, PhD, Treah Haggerty, MD, Gordon S. Smith, MB ChB   +4 more
doaj   +1 more source

Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles

Pharmaceuticals
Background/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman, Shimon Ben-Shabat, Amnon C. Sintov   +2 more
doaj   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Cannabidiol Prevents Heart Failure Dysfunction and Remodeling Through Preservation of Mitochondrial Function and Calcium Handling

JACC: Basic to Translational Science
Summary: Heart failure (HF) is characterized by energy deprivation, calcium (Ca2+) handling alterations, and inflammation: effects associated with mitochondrial dysfunction. Cannabidiol previously prevented mitochondrial dysfunction. Thus, it may prevent
Gerardo García-Rivas, PhD, Omar Lozano, PhD, Judith Bernal-Ramírez, PhD, Christian Silva-Platas, MSc, Felipe Salazar-Ramírez, MD, MSc, Abraham Méndez-Fernández, MSc, Carolina Morales-Ochoa, MSc, Hugo Alves-Figueiredo, PhD, Martín Rogelio Ramos-González, MD, PhD, Nestor Rubio-Infante, PhD, Eduardo Vázquez-Garza, MD, PhD, Luis A. Luévano-Martínez, PhD, Silvia López-Morán, MSc, Héctor Chapoy-Villanueva, PhD, James Bolton, MSc, José-Luis Velasco-Bolom, PhD, Paola Mendoza-Espinosa, PhD, Flavio F. Contreras-Torres, PhD, Carlos Jerjes-Sánchez, MD, Guillermo Torre-Amione, MD, PhD   +19 more
doaj   +1 more source

Disposition of a single oral dose of a cannabidiol medication in healthy cats

Frontiers in Veterinary Science, 2023
The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been for the treatment of epilepsy. Recently, the Food and Drug Administration has approved a highly purified cannabidiol medication for the add on ...
Tom Jukier, Crisanta Cruz-Espindola, Doug Martin, Dawn M. Boothe   +3 more
doaj   +1 more source