Results 61 to 70 of about 31,037 (228)

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer

Frontiers in Pharmacology, 2019
Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and
Andrea Tomko, Lauren O’Leary, Hilary Trask, John C. Achenbach, Steven R. Hall, Steven R. Hall, Kerry B. Goralski, Kerry B. Goralski, Lee D. Ellis, Denis J. Dupré   +9 more
doaj   +1 more source

Optimal condition of cannabis maceration to obtain the high cannabidiol and Δ9-tetrahydrocannabinol content [PDF]

Anais da Academia Brasileira de Ciências, 2019
: The aim of this work was to optimize a maceration condition of cannabis (Cannabis sativa L.). A circumscribed central composite experimental design was applied in this work.
CHAOWALIT MONTON, FAMEERA MADAKA, SUKANYA SETTHARAKSA, THANIYA WUNNAKUP, JIRAPORNCHAI SUKSAEREE, THANAPAT SONGSAK   +5 more
doaj   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Efficient Synthesis of Cannabinoid Acids

European Journal of Organic Chemistry, EarlyView.
In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai, Hikari Nishiguchi, Kayo Nakamura, Hiroko Abe, Akihiko Ishida, Manabu Tokeshi, Kyohei Higashi, Akiyoshi Saitoh, Hideyo Takahashi   +8 more
wiley   +1 more source

Cannabidiol impairs sperm quality and function in adult mice

Middle East Fertility Society Journal
Background Considering the growing therapeutic use of cannabidiol as well as the presence of cannabinoid receptors in sperm and its possible genotoxic activity, the effect of cannabidiol on sperm quality and function was examined.
Azam Govahi, Sahar Eghbali, Marziyeh Ajdary, Fatemehsadat Amjadi, Mahsa Nazari, Farzaneh Mohammadzadeh Kazorgah, Mehdi Mehdizadeh   +6 more
doaj   +1 more source

DETERMINACIÓN DE LA CAPACIDAD ANTIOXIDANTE DE UNA CREMA ELABORADA CON EXTRACTO ISOLADO DE CANNABIDIOL DE Cannabis sativa L. (CÁÑAMO)

infoANALITÍCA
En la presente investigación se determinó la capacidad antioxidante de una crema cosmética facial, elaborada a partir del extracto aislado (isolado) de cannabidiol. Para establecer la capacidad antioxidante.
Nataly Arciniegas S., Carlos Vélez, Daniela Coloma, Edison Osorio   +3 more
doaj   +1 more source

Cannabidiol (CBD) for the treatment of subcutaneous treprostinil (Remodulin®) site pain: a case report

Frontiers in Medicine, 2023
BackgroundPulmonary arterial hypertension occurs as a result of vascular remodeling and dysregulation of endothelial cells that narrows small pulmonary arteries and raises precapillary pressures.
Jacqueline Brewer, Amy Kimber
doaj   +1 more source

Cannabidiol enhances verbal episodic memory in healthy young participants: A randomized clinical trial [PDF]

, 2021
Cannabis contains a multitude of different compounds. One of them, cannabidiol - a non-psychoactive substance - might counteract negative effects of Δ-9-Tetrahydrocannabinol on hippocampus-dependent memory impairment.
Fehlmann, Bernhard, de Quervain, Dominique Jf, Hotz, Janine, Schicktanz, Nathalie S., Papassotiropoulos, Andreas, Nathalie S. Schicktanz, Dominique JF. de Quervain, Bernhard Fehlmann, Andreas Papassotiropoulos, Janine Hotz   +9 more
core   +1 more source

Cannabidiol\u27s Therapeutic Potential in Diabetes Mellitus

, 2023
Cannabidiol (CBD), derived from Cannabis sativa, stands as a plausible intervention for diabetes management and ...
Morell, Joseph
core   +2 more sources