Results 81 to 90 of about 31,037 (228)

The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review

open access: yesBiology
Cannabidiol is a non-psychoactive compound originating from Cannabis sativa L., with a promising therapeutic profile that influences numerous cellular processes.
Mihaela Jorgovan   +5 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

open access: yesEpilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang   +3 more
wiley   +1 more source

Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer

open access: yes, 2019
Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is a potential therapeutic agent for a variety of diseases such as inflammatory diseases, chronic neurodegenerative diseases, and cancers. Here, we found that the combination
Yoon A. Jeong   +14 more
core   +1 more source

“Over-the-counter” cannabidiol (CBD) sold in the community pharmacy setting in Colorado

open access: yes, 2020
Introduction: The use of cannabidiol is becoming so popular that even pharmacies now carry over-the-counter (OTC) cannabidiol products in Colorado, USA. Objective: The primary goal of this study was to evaluate cannabidiol products sold in the community ...
Leeds, Megan   +19 more
core   +1 more source

Epileptic drop attacks: More than just atonic seizures

open access: yesEpilepsia Open, EarlyView.
Abstract “Drop attacks” are not officially defined by the International League Against Epilepsy. Seizures are characterized by a sudden loss of control over the trunk and posture, leading to falls and injuries, and resolving within a few seconds. Accurately diagnosing the type of seizure is usually difficult due to limitations in clinical documentation
Tomonori Ono   +3 more
wiley   +1 more source

A Pilot Study: Using the Health Belief Model to Understand Cannabidiol Use in One Amish Community [PDF]

open access: yes, 2022
Amish use of complementary and alternative medicine is common, but little is known about their opinion of cannabidiol. Hemp legalization has popularized cannabidiol, making it available to Amish whose traditions limit access to scientific information ...
Branstetter, M. Laurie   +3 more
core  

Rhodium-Catalyzed Asymmetric Addition to 4- or 5‑Carbonyl-cycloenones through Dynamic Kinetic Resolution: Enantioselective Synthesis of (−)-Cannabidiol

open access: yes
The reaction of 4/5-carbonyl-cycloalkenone 1 or its achiral isomer 1′ with organoboronic acid 2 in the presence of a chiral diene (S,S)-Fc-tfb-rhodium catalyst gave disubstituted trans-cycloalkanone 3 with high diastereo- and enantioselectivity.
He Meng (33363)   +3 more
core   +1 more source

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice

open access: yes, 2017
This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm.
Hannah Harris   +4 more
core   +1 more source

Sustained seizure freedom with fenfluramine for refractory epilepsy due to 7q32‐q34 deletion syndrome

open access: yes
Epileptic Disorders, EarlyView.
Divya Veerapaneni   +2 more
wiley   +1 more source

Efficacy of stiripentol, fenfluramine, and their combination on clinical outcomes in Dravet syndrome: A preliminary report

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Stiripentol and fenfluramine are approved treatments for Dravet syndrome (DS), but real‐world data comparing their effectiveness and combined use remain limited. Our study aims to explore associations between treatment with stiripentol, fenfluramine, and their combination and clinical outcomes in patients with DS.
Paolo Surdi   +7 more
wiley   +1 more source

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