Results 101 to 110 of about 31,037 (228)

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study.

PLoS ONE, 2019
Recent evidence has raised in discussion the possibility that cannabidiol can act as a negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used computational methods to study the modulation exerted by cannabidiol on the effects
Hery Chung, Angélica Fierro, C David Pessoa-Mahana   +2 more
doaj   +1 more source

Transdiagnostic and symptom‐domain associations between mental illnesses and future self‐connectedness versus future self‐valence

JCPP Advances, EarlyView.
Abstract Background Future time perspective dimensions have been linked to various mental illnesses. Given the tendency for mental illnesses to co‐occur, it is necessary to disentangle associations between future‐oriented constructs and shared versus symptom‐domain‐specific psychopathology.
Yi Yang, Ingrid Obsuth, Jean‐Louis van Gelder, Denis Ribeaud, Manuel Eisner, Xinxin Zhu, Aja Louise Murray   +6 more
wiley   +1 more source

Cannabidiol [PDF]

Reactions Weekly, 2022
  +5 more sources

The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review [PDF]

FASEB J
Proposed mechanisms by which cannabidiol (CBD) promotes cutaneous wound healing. CBD modulates inflammatory and oxidative pathways, enhances fibroblast migration and proliferation, stimulates collagen deposition and extracellular matrix remodeling, and promotes angiogenesis, collectively contributing to improved tissue repair. ABSTRACT Cutaneous wounds
França J, de Melo Freitas R, Rosendo G, Carvalho M, de Oliveira G, dos Santos J, Tenorio F, da Silva J.   +7 more
europepmc   +2 more sources

Stepwise administration of de novo ketogenic parenteral nutrition for refractory epilepsy during prolonged bowel rest following duodenal perforation

JPGN Reports, EarlyView.
Abstract Ketogenic diet is an established therapy for pediatric patients with intractable epilepsy. By shifting energy metabolism from glucose to fat, the diet increases the production of ketone bodies, which alters neuronal excitability and modulates neurotransmitter signaling, thereby raising the seizure threshold.
Zaid Sheikh, Sarika Sewak, Danielle N. Mein, Joyce H. Matsumoto, Alvin P. Chan   +4 more
wiley   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Cannabidiol concentrations in individual lymph nodes

, 2022
Cannabidiol concentrations in individual lymph nodes Coverage (Spatial): Nottingham, United Kingdom Collection dates: August ...

core   +2 more sources

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?

Frontiers in Pharmacology, 2018
Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still mainly symptomatic, do not ...
Fernanda F. Peres, Fernanda F. Peres, Alvaro C. Lima, Jaime E. C. Hallak, Jaime E. C. Hallak, José A. Crippa, José A. Crippa, Regina H. Silva, Vanessa C. Abílio, Vanessa C. Abílio   +9 more
doaj   +1 more source

Cannabidiol Claims and Misconceptions [PDF]

Trends in Pharmacological Sciences, 2017
Once a widely ignored phytocannabinoid, cannabidiol now attracts great therapeutic interest, especially in epilepsy and cancer. As with many rising trends, various myths and misconceptions have accompanied this heightened public interest and intrigue. This forum article examines and attempts to clarify some areas of contention.
openaire   +2 more sources