Results 91 to 100 of about 31,037 (228)
Cannabidiol Treatment Ameliorates Acetaminophen-Induced Hepatotoxicity in Mice
, 2013 The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections,
Iyad Jresat +2 more
core +1 more source
Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care
Epilepsia Open, EarlyView.Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley +5 more
wiley +1 more source
, 2010 BackgroundThe two main constituents of cannabis, cannabidiol and δ9-tetrahydrocannabinol (THC), have opposing effects both pharmacologically and behaviourally when administered in the laboratory. Street cannabis is known to contain varying levels of each
Celia J. A. Morgan +3 more
core +1 more source
Epilepsia Open, EarlyView.Abstract Objectives CDKL5 deficiency disorder (CDD) is a developmental and epileptic encephalopathy characterized by early‐onset, treatment‐resistant seizures and severe neurodevelopmental impairment. Increasing evidence suggests that alterations in the gut–brain axis may contribute to disease pathophysiology, raising interest in microbiota‐targeted ...
Elisa Borghi +7 more
wiley +1 more source
Food Chemistry International, EarlyView.Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique +3 more
wiley +1 more source
Pharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats
PharmaceuticsKratom and cannabidiol products are used to self-treat a variety of conditions, including anxiety and pain, and to elevate mood. Research into the individual pharmacokinetic properties of commercially available kratom and cannabidiol products has been ...
Erin C. Berthold +8 more
doaj +1 more source
Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol
A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (−)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials.
Pesciaioli, Fabio +6 more
core +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Cannabidiol as a treatment for epilepsy [PDF]
, 2017 Despite an increasing number of anti-epileptic drugs (AEDs), the proportion of drug-resistant cases of epilepsy has remained fairly static at around 30% and the search for new and improved AEDs continues. Cannabis has been used as a medical treatment for
Robertson, Neil P. +4 more
core +1 more source