Results 71 to 80 of about 17,947 (225)

Pharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats

Pharmaceutics
Kratom and cannabidiol products are used to self-treat a variety of conditions, including anxiety and pain, and to elevate mood. Research into the individual pharmacokinetic properties of commercially available kratom and cannabidiol products has been ...
Erin C. Berthold, Shyam H. Kamble, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Yi-Hua Chiang, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Abhisheak Sharma   +8 more
doaj   +1 more source

Cannabidiol Claims and Misconceptions [PDF]

Trends in Pharmacological Sciences, 2017
Once a widely ignored phytocannabinoid, cannabidiol now attracts great therapeutic interest, especially in epilepsy and cancer. As with many rising trends, various myths and misconceptions have accompanied this heightened public interest and intrigue. This forum article examines and attempts to clarify some areas of contention.
openaire   +2 more sources

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study.

PLoS ONE, 2019
Recent evidence has raised in discussion the possibility that cannabidiol can act as a negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used computational methods to study the modulation exerted by cannabidiol on the effects
Hery Chung, Angélica Fierro, C David Pessoa-Mahana   +2 more
doaj   +1 more source

A Feasibility Assessment of the FDA Adverse Event Reporting System for the Detection of Cannabis-Related Safety Signals. [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Background The applicability of spontaneous reporting systems such as the US Food and Drug Administration Adverse Event Reporting System (FAERS) to detect cannabis‐related safety signals remains unclear due to the potential for discrepant reporting patterns between pharmaceutical and non‐pharmaceutical cannabis‐derived products (CDPs ...
Lopes POMV, Harris CS, Gravel CA.
europepmc   +2 more sources

Transdiagnostic and symptom‐domain associations between mental illnesses and future self‐connectedness versus future self‐valence

JCPP Advances, EarlyView.
Abstract Background Future time perspective dimensions have been linked to various mental illnesses. Given the tendency for mental illnesses to co‐occur, it is necessary to disentangle associations between future‐oriented constructs and shared versus symptom‐domain‐specific psychopathology.
Yi Yang, Ingrid Obsuth, Jean‐Louis van Gelder, Denis Ribeaud, Manuel Eisner, Xinxin Zhu, Aja Louise Murray   +6 more
wiley   +1 more source

Lipid Nanoparticle Formulations for the Skin Delivery of Cannabidiol

Pharmaceutics
Background/Objectives: The aims of this work were to formulate cannabidiol in different lipid carriers for skin delivery after topical application and to study their stability, interaction with the skin, and antibacterial activity.
Maria Natalia Calienni, Mirian Ana Scavone, Ana Paula Sanguinetti, Merlina Corleto, Magalí Rocío Di Meglio, Pablo Raies, Diego Sebastián Cristos, Paulo César Maffia, Jorge Montanari   +8 more
doaj   +1 more source

Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum

JSFA reports, EarlyView.
Abstract Background Fusarium graminearum, one of the causal agents of ear rot in maize and head blight of cereal grains, also infects hemp (Cannabis sativa L. containing a maximum of 0.3% tetrahydrocannabinol or THC). This fungal pathogen produces trichothecene mycotoxins when it infects maize and cereal grains, but little is known about its production
Isabelle A. Kagan, Magdalena Ricciardi, Henry S. Smith, Rachel R. Schendel, Robert Pearce, Nicole Gauthier   +5 more
wiley   +1 more source

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?

Frontiers in Pharmacology, 2018
Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still mainly symptomatic, do not ...
Fernanda F. Peres, Fernanda F. Peres, Alvaro C. Lima, Jaime E. C. Hallak, Jaime E. C. Hallak, José A. Crippa, José A. Crippa, Regina H. Silva, Vanessa C. Abílio, Vanessa C. Abílio   +9 more
doaj   +1 more source