Results 131 to 140 of about 2,964,584 (287)

CC 2010 Convocação 007

, 2012
Convocação da sétima sessão do CC de ...

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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CC 2009 Convocação 009

, 2012
Convocação da nona sessão do CC de ...

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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Alfabetización en salud a través de las competencias

Enseñanza de las Ciencias, 2019
En este trabajo se presenta una propuesta para la alfabetización en salud a través de la concreción y definición de las competencias que debe adquirir el alumnado durante la Educación Obligatoria.
Valentín Gavidia Catalán, Anabella Garzón Fernández, Marta Talavera Ortega, Cristina Sendra Mocholí, Olga Mayoral García-Berlanga   +4 more
doaj  

CC 2010 Ata 02

, 2012
Ata da segunda sessão do CC em ...

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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

POTENCIAL QUANTITATIVO DAS ÁGUAS SUBTERRÂNEAS EM

Revista Águas Subterrâneas, 2011
Este trabalho avalia quantitativamente as águas subterrâneas em Maracanaú, porção sudoeste da Região Metropolitana de Fortaleza, Ceará. As reservas permanentes e renováveis são de 3.307.500m3 e 220.482m3/ano, respectivamente.
Ediu Carlos Lopes Lemos, Itabaraci Nazareno Cavalcante, Almany Costa Santos, Maria da Conceição Rabelo Gomes, Larissa Silva Silva   +4 more
doaj  

CC 2010 Ata 11

, 2012
Ata da décima primeira sessão do CC em ...

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Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source