Results 51 to 60 of about 4,418,677 (237)

An Assessment of Observed and Simulated Temperature Variability in Sierra de Guadarrama

Atmosphere, 2020
This work provides a first assessment of temperature variability at interannual and decadal timescales in Sierra de Guadarrama, a high mountain protected area of the Central System in the Iberian Peninsula. Observational data from stations located in the
Cristina Vegas-Cañas, J. Fidel González-Rouco, Jorge Navarro-Montesinos, Elena García-Bustamante, Etor E. Lucio-Eceiza, Félix García-Pereira, Ernesto Rodríguez-Camino, Andrés Chazarra-Bernabé, Inés Álvarez-Arévalo   +8 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Rectal Squamous Cell Carcinoma: A Case Report Of A Rare Histology [PDF]

Iranian Journal of Colorectal Research, 2019
The rectum is an unusual and unlikely site for squamous carcinoma of the gastrointestinal tract. The clinicalpresentation of this rare histology though, is similar to adenocarcinoma rectum.
Sankal Psingh, Nishant Lohia, Manoj Prashar, Subramananiam Anand, Sundaram Viswanath, Richa Ranjan   +5 more
doaj  

Conversor CC–CC Bidirecional Push-Pull / Flyback

Eletrônica de Potência, 2019
Este artigo apresenta uma nova topologia de conversor CC–CC bidirecional Push-Pull / Flyback que, em ambos os sentidos de operação, são estudados detalhadamente, incluindo a análise teórica e matemática, o ganho estático nos três modos de condução que ...
Menaouar B. El Kattel, Robson Mayer, Maicon D. Possamai, Sérgio V. G. Oliveira   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Health literacy through competences

Enseñanza de las Ciencias, 2019
This paper presents a proposal for health literacy through the specification and definition of the competences that students must acquire during Compulsory Education.
Valentín Gavidia Catalán, Anabella Garzón Fernández, Marta Talavera Ortega, Cristina Sendra Mocholí, Olga Mayoral García-Berlanga   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Evaluating the impact of climate communication activities by scientists: what is known and necessary? [PDF]

Geoscience Communication
Climate scientists and others are urged to communicate climate science in a way that non-scientific audiences can understand, that makes it more relevant to their lives and experiences, and that inspires them to act.
F. Wijnen, M. Strick, M. Bos, E. van Sebille   +3 more
doaj   +1 more source