Results 1 to 10 of about 54,915 (113)

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL. [PDF]

CNS Neurosci Ther
Beside mural cells, NOTCH3 is expressed in astrocytes. Expression of Aquaporin 4 (AQP4), the core mediator of glymphatic functions, is decreased in CADASIL brain. Consequently, glymphatic activities are impaired. Diminished AQP4 expression is attributed to the suppression of RUNX1‐CMYB‐AQP4 signaling due to NOTCH3 mutation in astrocytes.
Li C, Li H, Men X, Wang Y, Kang X, Hu M, Su X, Wang S, Lu D, Shen S, Huang H, Deng X, Liu Y, Zhang L, Cai W, Wu A, Lu Z.   +16 more
europepmc   +2 more sources

Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree. [PDF]

Acta Crystallogr D Struct Biol
Variants HNL16, HNL40 and HNL71 of hydroxynitrile lyase from Hevea brasiliensis contain 16, 40 and 71 mutations, respectively, to make increasingly larger regions surrounding the active site identical in sequence to the esterase SABP2. X‐ray structures of HNL40 and HNL71 reveal changes to the oxyanion hole and a new tunnel, which may contribute to ...
Pierce CT, Tan P, Greenberg LR, Walsh ME, Shi K, Nguyen AH, Meixner EL, Sarak S, Aihara H, Evans RL, Kazlauskas RJ.   +10 more
europepmc   +2 more sources

Fast event-based electron counting for small-molecule structure determination by MicroED. [PDF]

Acta Crystallogr C Struct Chem
Fast readout event‐based electron counting (EBEC) is a promising detection strategy to determine accurate ab initio structures of beam‐sensitive small molecules by MicroED. A fast EBEC approach enhances the dynamic range of MicroED data by limiting the likelihood of coincidence loss (CL) – the undercounting of electrons due to their spatially and ...
Vlahakis N, Qu S, Richards LS, Moraes LS, Cascio D, Nelson HM, Rodriguez JA.   +6 more
europepmc   +2 more sources

The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap. [PDF]

Acta Crystallogr D Struct Biol
The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins.The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins. FeSII is an adrenodoxin‐type ferredoxin that forms a dimer in solution.
Kabasakal BV, McFarlane CR, Cotton CAR, Schmidt A, Kung A, Lieber L, Murray JW.   +6 more
europepmc   +2 more sources

Peer review of the pesticide risk assessment of the active substance clomazone [PDF]

EFSA J
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Denmark, and co‐rapporteur Member State, Germany, for the pesticide active substance clomazone are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Monica Fittipaldi Broussarad, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Alexandra Piti, Simone Rizzuto, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +51 more
europepmc   +2 more sources

Peer review of the pesticide risk assessment of the active substance bixlozone. [PDF]

EFSA J
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, The Netherlands for the pesticide active substance bixlozone are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009
European Food Safety Authority (EFSA), Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Santonja GG, Gouliarmou V, Halling K, Nogareda LH, Ippolito A, Istace F, Jarrah S, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Louisse J, Lythgo C, Magrans O, Mangas I, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Rizzuto S, Romac A, Rortais A, Santos M, Serafimova R, Sharp R, Szentes C, Terron A, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L.   +51 more
europepmc   +2 more sources

Investigation of how gate residues in the main channel affect the catalytic activity of Scytalidium thermophilum catalase. [PDF]

Acta Crystallogr D Struct Biol
Scytalidium thermophilum produces a catalase enzyme that is capable of oxidizing o‐diphenolic and some p‐diphenolic compounds in the absence of hydrogen peroxide. To better understand the role of the main channel in phenol oxidase activity, the gate residues Glu484 and Thr188 in the upper part of the main channel were investigated in a combined kinetic,
Yuzugullu Karakus Y, Goc G, Zengin Karatas M, Balci Unver S, Yorke BA, Pearson AR.   +5 more
europepmc   +2 more sources

The effect of dietary paeonol on growth performance, antioxidant enzyme activities and gene expressions of Genetic Improvement of Farmed Tilapia juveniles (Oreochromis niloticus)

Aquaculture Reports, 2022
This experiment was conducted to determine the effect of dietary paeonol levels on growth performance, serum biochemical parameters, antioxidant enzyme activities and transcriptional expression of antioxidant- and immune-related genes in Genetic ...
Yaxue Li, Xing Lu, Weihua Gao, Lijuan Yu, Hua Wen, Ming Jiang, Juan Tian, Fan Wu   +7 more
doaj   +1 more source

Setting of an import tolerance for lambda‐cyhalothrin in avocados

EFSA Journal, Volume 21, Issue 12, December 2023., 2023
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Greece to set an import tolerance for the active substance lambda‐cyhalothrin in avocados.
EFSA European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, Alessia Verani   +21 more
wiley   +1 more source

Atypical homodimerization revealed by the structure of the (S)‐enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum

Acta Crystallographica Section D, Volume 79, Issue 11, Page 956-970, November 2023., 2023
Crystallographic structures of the (S)‐enantioselective haloalkane dehalogenase DmmarA from the waterborne pathogenic microbe Mycobacterium marinum were determined at 1.6 and 1.85 Å resolution. The structures reveal a previously unobserved mode of homodimerization, which is predominantly mediated through unusual L5‐to‐L5 loop interactions.Haloalkane ...
Karolina Snajdarova, Sérgio M. Marques, Jiri Damborsky, David Bednar, Martin Marek   +4 more
wiley   +1 more source