Results 1 to 10 of about 52,774 (113)

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL. [PDF]

CNS Neurosci Ther
Beside mural cells, NOTCH3 is expressed in astrocytes. Expression of Aquaporin 4 (AQP4), the core mediator of glymphatic functions, is decreased in CADASIL brain. Consequently, glymphatic activities are impaired. Diminished AQP4 expression is attributed to the suppression of RUNX1‐CMYB‐AQP4 signaling due to NOTCH3 mutation in astrocytes.
Li C, Li H, Men X, Wang Y, Kang X, Hu M, Su X, Wang S, Lu D, Shen S, Huang H, Deng X, Liu Y, Zhang L, Cai W, Wu A, Lu Z.   +16 more
europepmc   +2 more sources

Setting of an import tolerance for lambda-cyhalothrin in avocados. [PDF]

EFSA J, 2023
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Greece to set an import tolerance for the active substance lambda‐cyhalothrin in avocados.
EFSA European Food Safety Authority (EFSA), Bellisai G, Bernasconi G, Cabrera LC, Castellan I, Del Aguila M, Ferreira L, Santonja GG, Greco L, Jarrah S, Leuschner R, Miron I, Nave S, Pedersen R, Reich H, Ruocco S, Santos M, Scarlato AP, Szot M, Theobald A, Tiramani M, Verani A.   +21 more
europepmc   +2 more sources

The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap. [PDF]

Acta Crystallogr D Struct Biol
The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins.The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins. FeSII is an adrenodoxin‐type ferredoxin that forms a dimer in solution.
Kabasakal BV, McFarlane CR, Cotton CAR, Schmidt A, Kung A, Lieber L, Murray JW.   +6 more
europepmc   +2 more sources

Peer review of the pesticide risk assessment of the active substance clomazone [PDF]

EFSA J
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Denmark, and co‐rapporteur Member State, Germany, for the pesticide active substance clomazone are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Monica Fittipaldi Broussarad, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Alexandra Piti, Simone Rizzuto, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +51 more
europepmc   +2 more sources

Peer review of the pesticide risk assessment of the active substance bixlozone. [PDF]

EFSA J
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, The Netherlands for the pesticide active substance bixlozone are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009
European Food Safety Authority (EFSA), Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Santonja GG, Gouliarmou V, Halling K, Nogareda LH, Ippolito A, Istace F, Jarrah S, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Louisse J, Lythgo C, Magrans O, Mangas I, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Rizzuto S, Romac A, Rortais A, Santos M, Serafimova R, Sharp R, Szentes C, Terron A, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L.   +51 more
europepmc   +2 more sources

Investigation of how gate residues in the main channel affect the catalytic activity of Scytalidium thermophilum catalase. [PDF]

Acta Crystallogr D Struct Biol
Scytalidium thermophilum produces a catalase enzyme that is capable of oxidizing o‐diphenolic and some p‐diphenolic compounds in the absence of hydrogen peroxide. To better understand the role of the main channel in phenol oxidase activity, the gate residues Glu484 and Thr188 in the upper part of the main channel were investigated in a combined kinetic,
Yuzugullu Karakus Y, Goc G, Zengin Karatas M, Balci Unver S, Yorke BA, Pearson AR.   +5 more
europepmc   +2 more sources

Social movement of Ural Germans in 1989–2019 (ethnic projects and leaders)

Вестник археологии, антропологии и этнографии, 2020
The present article considers the history of the social movement of Russian Germans in the Urals, as well as the factors in its formation, on the basis of previously unknown sources (archival and field materials obtained by the author).
T.S. Kisser
doaj   +1 more source

Atypical homodimerization revealed by the structure of the (S)‐enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum

Acta Crystallographica Section D, Volume 79, Issue 11, Page 956-970, November 2023., 2023
Crystallographic structures of the (S)‐enantioselective haloalkane dehalogenase DmmarA from the waterborne pathogenic microbe Mycobacterium marinum were determined at 1.6 and 1.85 Å resolution. The structures reveal a previously unobserved mode of homodimerization, which is predominantly mediated through unusual L5‐to‐L5 loop interactions.Haloalkane ...
Karolina Snajdarova, Sérgio M. Marques, Jiri Damborsky, David Bednar, Martin Marek   +4 more
wiley   +1 more source

Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2‐vWa construct improves crystal order and diffraction limits

Acta Crystallographica Section D, Volume 79, Issue 10, Page 925-943, October 2023., 2023
Using a 1TEL–CMG2‐vWa construct, evidence is provided to support limiting the flexibility of linkers between TELSAM and proteins of interest and considering retaining polyhistidine purification tags in TELSAM‐fusion constructs. The phenomenon of TELSAM‐polymer flipping is also identified and a correction strategy is developed.TELSAM‐fusion ...
Parag L. Gajjar, Maria J. Pedroza Romo, Celeste M. Litchfield, Miles Callahan, Nathan Redd, Supeshala Nawarathnage, Sara Soleimani, Jacob Averett, Elijah Wilson, Andrew Lewis, Cameron Stewart, Yi-Jie Tseng, Tzanko Doukov, Andrey Lebedev, James D. Moody   +14 more
wiley   +1 more source

Editorial

Revista Arqueologia Pública, 2021
Há uma emoção em ver a superfície marítima, mas também há uma comoção em descobrir aquilo que está nas profundezas do mar. Desbravar, mergulhar, ir longe das areias, se encantar com a grandeza da natureza e a história.
Joana Schossler , Aline Vieira Carvalho   +1 more
doaj   +1 more source