Results 11 to 20 of about 80,465 (162)

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL [PDF]

CNS Neuroscience &Therapeutics, Volume 31, Issue 1, January 2025.
Beside mural cells, NOTCH3 is expressed in astrocytes. Expression of Aquaporin 4 (AQP4), the core mediator of glymphatic functions, is decreased in CADASIL brain. Consequently, glymphatic activities are impaired. Diminished AQP4 expression is attributed to the suppression of RUNX1‐CMYB‐AQP4 signaling due to NOTCH3 mutation in astrocytes.
Chunyi Li, Hui Li, Xuejiao Men, Yuge Wang, Xinmei Kang, Mengyan Hu, Xiaotao Su, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Xiaohui Deng, Yuxin Liu, Lei Zhang, Wei Cai, Aimin Wu, Zhengqi Lu   +16 more
wiley   +2 more sources

The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap [PDF]

Acta Crystallographica Section D, Volume 80, Issue 8, Page 599-604, August 2024.
The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins.The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins. FeSII is an adrenodoxin‐type ferredoxin that forms a dimer in solution.
Burak V. Kabasakal, Ciaran R. McFarlane, Charles A. R. Cotton, Anna Schmidt, Andrea Kung, Lucas Lieber, James W. Murray   +6 more
wiley   +2 more sources

Peer review of the pesticide risk assessment of the active substance bixlozone [PDF]

EFSA Journal, Volume 22, Issue 10, October 2024.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, The Netherlands for the pesticide active substance bixlozone are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Laia Herrero Nogareda, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Anamarija Romac, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +51 more
wiley   +2 more sources

Peer review of the pesticide risk assessment of the active substance clomazone [PDF]

EFSA Journal, Volume 23, Issue 2, February 2025.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Denmark, and co‐rapporteur Member State, Germany, for the pesticide active substance clomazone are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Monica Fittipaldi Broussarad, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Samira Jarrah, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Alexandra Piti, Simone Rizzuto, Agnès Rortais, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Andrea Terron, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +51 more
wiley   +2 more sources

Investigation of how gate residues in the main channel affect the catalytic activity of Scytalidium thermophilum catalase [PDF]

Acta Crystallographica Section D, Volume 80, Issue 2, Page 101-112, February 2024.
Scytalidium thermophilum produces a catalase enzyme that is capable of oxidizing o‐diphenolic and some p‐diphenolic compounds in the absence of hydrogen peroxide. To better understand the role of the main channel in phenol oxidase activity, the gate residues Glu484 and Thr188 in the upper part of the main channel were investigated in a combined kinetic,
Yonca Yuzugullu Karakus, Gunce Goc, Melis Zengin Karatas, Sinem Balci Unver, Briony A. Yorke, Arwen R. Pearson   +5 more
wiley   +2 more sources

[123I]CC1: A PARP-Targeting, Auger Electron–Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer

Journal of Nuclear Medicine, 2023
Visual Abstract Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme.
C. Chan, Zijun Chen, Florian Guibbal, Gemma Dias, Gianluca Destro, E. O’Neill, M. Veal, Doreen Lau, M. Mosley, Thomas C. Wilson, Véronique Gouverneur, B. Cornelissen   +11 more
semanticscholar   +1 more source

Batik Nitik 960 Dataset for Classification, Retrieval, and Generator

International Conference on Data Technologies and Applications, 2023
Batik is one of the traditional heritages of Indonesia, with each motif of batik having a profound cultural and philosophical significance. This article introduces Batik Nitik 960 dataset from Yogyakarta, Indonesia. The dataset was extracted from a piece
A. E. Minarno, I. Soesanti, H. A. Nugroho   +2 more
semanticscholar   +1 more source

Safety and Efficacy of Aripiprazole 2-Month Ready-to-Use 960 mg: Secondary Analysis of Outcomes in Adult Patients With Schizophrenia in a Randomized, Open-label, Parallel-Arm, Pivotal Study.

Journal of Clinical Psychiatry, 2023
Objective: Aripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a new long-acting injectable antipsychotic formulation for administration every 2 months.
L. Citrome, P. Such, Murat Yildirim, J. Madera-McDonough, C. Beckham, Zhen Zhang, F. Larsen, M. Harlin   +7 more
semanticscholar   +1 more source

Occupation and SARS-CoV-2 infection risk among 108 960 workers during the first pandemic wave in Germany

Scandinavian Journal of Work, Environment and Health, 2022
Objective The aim of this study was to identify the occupational risk for a SARS-CoV-2 infection in a nationwide sample of German workers during the first wave of the COVID-19 pandemic (1 February–31 August 2020).
M. Reuter, M. Rigo, M. Formazin, F. Liebers, U. Latza, S. Castell, K. Jöckel, K. Greiser, K. Michels, G. Krause, Stefan Albrecht, Ilter Öztürk, O. Kuss, Klaus Berger, Benedikt M J Lampl, M. Leitzmann, H. Zeeb, K. R. Starke, S. Schipf, C. Meinke-Franze, W. Ahrens, A. Seidler, B. Klee, T. Pischon, A. Deckert, B. Schmidt, R. Mikolajczyk, A. Karch, B. Bohn, H. Brenner, B. Holleczek, N. Dragano   +31 more
semanticscholar   +1 more source

The novel fosfomycin resistance gene fosY is present on a genomic island in CC1 methicillin-resistant Staphylococcus aureus

Emerging Microbes and Infections, 2022
Fosfomycin has gained attention as a combination therapy for methicillin-resistant Staphylococcus aureus infections. Hence, the detection of novel fosfomycin-resistance mechanisms in S. aureus is important.
Yiyi Chen, S. Ji, Lu Sun, Hai-ping Wang, Feiteng Zhu, Mengzhen Chen, Hemu Zhuang, Zhengan Wang, Shengnan Jiang, Yunsong Yu, Yan Chen   +10 more
semanticscholar   +1 more source