Results 11 to 20 of about 54,915 (113)

Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2‐vWa construct improves crystal order and diffraction limits

open access: yesActa Crystallographica Section D, Volume 79, Issue 10, Page 925-943, October 2023., 2023
Using a 1TEL–CMG2‐vWa construct, evidence is provided to support limiting the flexibility of linkers between TELSAM and proteins of interest and considering retaining polyhistidine purification tags in TELSAM‐fusion constructs. The phenomenon of TELSAM‐polymer flipping is also identified and a correction strategy is developed.TELSAM‐fusion ...
Parag L. Gajjar   +14 more
wiley   +1 more source

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

open access: yesMedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong   +10 more
wiley   +1 more source

Were there any tells in the Coţofeni culture area?

open access: yesБългарско е-Списание за Археология, 2022
The approach to the topic of tells in the North-Danube area, between 3500 and 2800 BC, corresponding to the Coţofeni culture (in Bulgaria, Magura–Coţofeni, Tărnava culture) has been inconsistent. This study aims to clarify a series of archaeological and
Cristian Ioan Popa
doaj   +1 more source

A temperature‐compensated linear GaAs HBT power amplifier for small‐cell applications in −25 to 125∘C$^\circ \rm C$ lunar environment

open access: yesElectronics Letters, Volume 58, Issue 18, Page 684-686, August 2022., 2022
Abstract A two‐stage 920–960 MHz power amplifier (PA) in GaAs heterojunction bipolar transistor (HBT) process is demonstrated for small‐cell communications in the lunar environment. To cope with the temperature fluctuations during lunar days, a novel complementary to absolute temperature (CTAT) biasing scheme is proposed for the PA to achieve an ultra ...
Jiajin Li, Gary Zhang, Chang Yang
wiley   +1 more source

Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas

open access: yesBrain Pathology, Volume 32, Issue 4, July 2022., 2022
We studied the epigenomic landscape of intracranial mesenchymal tumor with FET‐CREB fusion, an emerging CNS tumor entity that occurs primarily in children and young adults. These tumors resolved into two epigenetic subgroups with divergent clinical outcomes that were distinct from meningiomas and all analyzed extracranial sarcomas.
Emily A. Sloan   +32 more
wiley   +1 more source

Reconstructing craton‐scale tectonic events via in situ Rb‐Sr geochronology of poly‐phased vein mineralization

open access: yesTerra Nova, Volume 33, Issue 5, Page 502-510, October 2021., 2021
Abstract Fault‐ and fracture‐hosted multi‐stage mineral assemblages that formed by fracture reactivation and fluid migration, constitute archives of the tectonic evolution of Precambrian cratons. Complex intergrowth patterns of these mineral records often hinder absolute dating of mineralization events for geological models.
Mikael Tillberg   +5 more
wiley   +1 more source

The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain

open access: yesActa Crystallographica Section D, Volume 77, Issue 6, Page 854-866, June 2021., 2021
The crystal structures of three viral Src kinase (v‐Src) SH3‐domain variants have been determined in order to obtain insights into the roles of these oncogenic mutations in the function of v‐Src.Src kinase belongs to the family of Src‐related nonreceptor tyrosine kinases.
M. Carmen Salinas-Garcia   +2 more
wiley   +1 more source

Homogeneous batch micro‐crystallization of proteins from ammonium sulfate

open access: yesActa Crystallographica Section D, Volume 77, Issue 2, Page 194-204, February 2021., 2021
This work demonstrates how the precipitating properties of ammonium sulfate can be exploited to drive the transition from vapour‐diffusion conditions to large‐scale batch micro‐crystallization and how the specific ammonium sulfate concentration can further be used to fine‐tune microcrystal size and size distribution.The emergence of X‐ray free‐electron
Claudia Stohrer   +8 more
wiley   +1 more source

The moulds from Velebit and European bronze age metal anvils [PDF]

open access: yesStarinar, 2019
During the first excavations of the cemetery dating from the Bronze Age and Early Antiquity in the village of Velebit near Kanjiža (Northern Serbia) one of the excavated artefacts was found to belong to a used and broken stone mould for casting ...
Armbruster Barbara   +3 more
doaj   +1 more source

Providing a Comparative Geo-referenced Database for Religious Artefacts in Ai Khanoum and Taxila’s Sirkap Mound

open access: yesJournal of Open Archaeology Data, 2023
The cities of Taxila in Pakistan, and Ai Khanoum in Afghanistan, are emblematic of the post-Alexandrian and post-Mauryan political landscapes of the broader South and Central Asian regions. While both have been thoroughly excavated, there has been little
Christos Nikolaou
doaj   +1 more source

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