Results 41 to 50 of about 128,485 (263)

Molekulare Testungen in der Cholangiokarzinom-Diagnostik

Monitor Versorgungsforschung
Hintergrund: Cholangiokarzinome (CCA) sind eine heterogene Gruppe maligner Tumoren mit schlechter Prognose. Next-Generation-Sequencing (NGS) ermöglicht die Identifikation tumorspezifischer genetischer Veränderungen und dient als Grundlage für ...
Tabea Poos MSc, Melina Sophie Kurte MA, Ann-Cathrine Froitzheim MSc, Prof. Dr. med. Christoph Roderburg MHBA, Prof. Dr. med. Alexander Quaas, Dr. med. Dirk Waldschmidt, Prof. Dr. rer. medic. Florian Kron   +6 more
doaj   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Feijão-mungo

Agropecuária Catarinense, 2021
Esse trabalho tem por objetivo apresentar uma nova opção de cultivo para a pequena propriedade agrícola familiar. Trata-se do feijão­-mungo, uma cultura ainda pouco conhecida por técnicos e agricultores do Estado de Santa Catarina.
Shiow Shong Lin, Antonio Carlos Alves
doaj   +2 more sources

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Perception de la notion de litige sportif par les acteurs du mouvement sportif camerounais : entre et lueurs et leurres [PDF]

SHS Web of Conferences, 2016
Depuis sa création en 2001, la Chambre de Conciliation et d'Arbitrage (CCA) du Comité National Olympique et Sportif du Cameroun (CNOSC) n'avait jamais connu une aussi grande sollicitation en l'espace de quelques mois.
Romuald Dey Yelem Franck
doaj   +1 more source

CCA: A Calculus of Context-Aware Ambients [PDF]

2009 International Conference on Advanced Information Networking and Applications Workshops, 2009
We present a process calculus, CCA, for the modelling and verification of mobile systems that are context-aware. This process calculus is built upon the calculus of mobile ambients and introduces new constructs to enable ambients and processes to be aware of the environment in which they are being executed.
Siewe, Francois, Cau, A. (Antonio), Zedan, Hussein   +2 more
openaire   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Propagação de videira in vitro: produção de plantas matrizes básicas de porta-enxento

Agropecuária Catarinense, 2021
As técnicas de cultura in vitro apresentam um grande potencial para a produção de plantas matrizes e mudas de alta qualidade genética e sanidade comprovada.
Aparecido Lima da Silva, Enio Schuck, Robison Borges, Flávia Maia Moreira, Marcelo Borghezan, Liziane Kadine Antunes de Moraes, Célio Air Mikulski, Carolina Quiumento Velloso   +7 more
doaj  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source