Results 181 to 190 of about 3,591 (208)

Sensitivity of the CCM1 hydrologic cycle to CO₂

Journal of Geophysical Research: Atmospheres, 1996
To better understand the global hydrologic cycle, climatological simulations with the National Center for Atmospheric Research global atmospheric general circulation model (GCM) or community climate model (CCM1), coupled to a mixed layer model, are compared to available global hydrologic observations.
J. O. Roads, S. Marshall, R. Oglesby, S.‐C. Chen   +3 more
openaire   +1 more source

Neuro-oculo-cutaneous cavernous hemangiomas: a CCM1 mutation-associated phakomatosis

Journal of American Association for Pediatric Ophthalmology and Strabismus, 2017
Evaluation for intracranial lesions in a patient with retinal cavernous hemangiomas is vital for early recognition of this heritable and potentially life-threatening disease. We report a case of a highly penetrant but variably expressed form of cerebral cavernous malformation syndrome with cerebral, cutaneous, and retinal cavernomas in a family found ...
Mary T, Labowsky, Scott D, Walter, Marie T, McDonald, Prithvi, Mruthyunjaya   +3 more
openaire   +2 more sources

Modifications and Enhancements to the NCAR Community Climate Model (CCM1)

1989
This report describes the two new unresequenced program libraries created for CCM1 in the early fall, 1988 which incorporate fixes to several bugs that were discovered earlier, improvements in computational performance, and a number of other enhancements to components of the model.
Hack, James, Bath, Linda, Williamson, Gloria, Boville, Byron   +3 more
openaire   +1 more source

CCM1 gene mutations in families segregating cerebral cavernous malformations

Neurology, 2001
Cerebral cavernous malformations (CCM) are vascular anomalies, sometimes inherited as an autosomal dominant trait, which can cause strokes and seizures. Recently, mutations of the CCM1 gene (chromosome 7q) have been found in a subset of families. The authors found 10 new mutations by screening 29 families and five seemingly sporadic cases of CCM.
W J, Davenport, A M, Siegel, J, Dichgans, P, Drigo, I, Mammi, P, Pereda, N W, Wood, G A, Rouleau   +7 more
openaire   +2 more sources

Novel CCM1 mutation in a patient with paraparesis and thoracic cord cavernous malformation

Neurology, 2005
Cerebral cavernous malformations (CCMs) are heterogeneous vascular malformations that may cause headaches, seizures, focal neurologic deficits, stroke, and death. With an incidence of 0.1 to 0.5%, they constitute 10 to 20% of all CNS vascular malformations.1 Heterozygous loss-of-function mutations have been identified in KRIT1 ( CCM1 ),2 MGC4607 ( CCM2
M F, Waters, D C, Shields, N A, Martin, R W, Baloh, J C, Jen   +4 more
openaire   +2 more sources

Germline mutations in the CCM1 gene, encoding Krit1, cause cerebral cavernous malformations

Annals of Neurology, 2001
AbstractMutations in the Krit1 gene have been recently discovered as the cause of hereditary cerebral cavernous angioma. We sought the possibility that de novo, noninherited mutations of Krit1 also cause cavernous angioma. A patient with two cerebral malformations carries a heterozygous deletion of two base pairs (741delTC) in exon VI of the Krit1 gene.
M, Lucas, A F, Costa, M, Montori, F, Solano, M D, Zayas, G, Izquierdo   +5 more
openaire   +2 more sources

A 100-Yr CCM1 Simulation of North China's Hydrologic Cycle

Journal of Climate, 1996
Abstract The year to year variability in North China's summertime hydrologic cycle is analyzed in a 100-yr CCM1 simulation. Eastern North America is included for comparative purposes with earlier work. On the basis of the simulated inherent variability of the regionally averaged soil moisture, each year's climate pattern over these two regions is ...
Zengquan Fan, Robert J. Oglesby
openaire   +1 more source

Whole-genome Omics delineates the function of CCM1 within the CmPn networks

2023
Abstract Introduction Cerebral cavernous malformations (CCMs) are abnormal dilations of brain capillaries that increase the risk of hemorrhagic strokes. Mutations in the KRIT1, MGC4607, and PDCD10 genes cause CCMs, with mutations in CCM1 accounting for about 50% of familial cases.
Jacob Croft, Brian Grajeda, Luis A Aguirre, Liyuan Gao, Johnathan Abou-Fadel, Victor Sheng, Jun Zhang   +6 more
openaire   +1 more source

Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain

2020
Cerebral cavernous malformation (CCM) is driven by changes in the cerebral microvascular endothelial cell population. Mouse models of CCM have successfully recapitulated the disease in vivo; however, dissection of the disease pathogenesis and molecular mechanism is challenging in vivo due to limited access to the involved tissue in live animals ...
Nicholas, Nobiletti, Angela J, Glading
openaire   +2 more sources

Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1)

Acta Neuropathologica, 2002
Cavernous malformations are vascular anomalies that can cause severe neurological deficits, seizures and hemorrhagic stroke if these lesions are located in the brain. In patients with cavernomas, constitutional mutations of the KRIT1 gene have been identified. The pathogenetic mechanisms leading to cerebral cavernous malformations (CCM) development are
Hildegard, Kehrer-Sawatzki, Monika, Wilda, Veit M, Braun, Hans-Peter, Richter, Horst, Hameister   +4 more
openaire   +2 more sources