The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation [PDF]
Brain and BehaviorPurpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and hemorrhagic conversion of cerebral cavernous malformations (CCM) and to appraise the therapeutic potential of immune‐directed ...
Xuesai Zhu +3 more
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Familial Multiple Cavernous Malformation Syndrome: MR Features in This Uncommon but Silent Threat [PDF]
Journal of the Belgian Society of Radiology, 2016 Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon.
Marc Mespreuve +2 more
doaj +5 more sources
Cranial ultrasonography in diagnosis of infantile cerebral cavernous malformation [PDF]
Clinical Case Reports, 2023 The case of an infantile cerebral cavernous malformation detected by transfontanelle cranial ultrasonography. Infantile cerebral cavernous malformations tend to cause more major bleeding compared to those in older groups, so early detection and treatment
Shuya Kaneko, Iku Ikeno, Hideo Wada
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Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations [PDF]
Genetics in Medicine, 2015 PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Robert Shenkar +2 more
exaly +4 more sources
Signalling through cerebral cavernous malformation protein networks [PDF]
Open Biology, 2020 Cerebral cavernous malformations (CCMs) are neurovascular abnormalities characterized by thin, leaky blood vessels resulting in lesions that predispose to haemorrhages, stroke, epilepsy and focal neurological deficits.
Valerie L. Su, David A. Calderwood
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy [PDF]
Brain and BehaviorIntroduction Cerebral cavernous malformation (CCM) is a type of cerebrovascular abnormality in the central nervous system linked to both germline and somatic genetic mutations.
Zhuangzhuang Zhang +3 more
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Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives [PDF]
Frontiers in Immunology, 2022 Cerebral cavernous malformation (CCM) is a type of vascular anomaly that arises due to the dyshomeostasis of brain capillary networks. In the past two decades, many advances have been made in this research field.
Tianqi Tu +6 more
doaj +2 more sources
A Spinal Cavernous Malformation in Multiple Cerebral Cavernous Venous Malformations Syndrome
Journal of the Belgian Society of Radiology, 2023 Teaching Point: In patients with familial multiple cavernous malformation syndrome with acute focal neurological deficit, a symptomatic spinal cavernous malformation must be included in the differential diagnosis.
Guillaume Vangrinsven +2 more
doaj +5 more sources
Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation [PDF]
Brain Sciences, 2023 Cerebral cavernous malformation (CCM) is a common cerebrovascular malformation causing intracranial hemorrhage, seizures, and focal neurologic deficits.
Ying Li +9 more
doaj +2 more sources
Functional outcome after pediatric cerebral cavernous malformation surgery [PDF]
Scientific Reports, 2023 The purpose of this study was to investigate the functional outcome following surgical resection of cerebral cavernous malformations (CCM) in pediatric patients.
Laurèl Rauschenbach +11 more
doaj +2 more sources