Results 1 to 10 of about 1,146 (115)

Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1.

PLoS ONE, 2012
Loss-of-function mutations of the KRIT1 gene (CCM1) have been associated with the Cerebral Cavernous Malformation (CCM) disease, which is characterized by serious alterations of brain capillary architecture.
Paolo Guazzi, Luca Goitre, Elisa Ferro, Valentina Cutano, Chiara Martino, Lorenza Trabalzini, Saverio Francesco Retta   +6 more
doaj   +6 more sources

KRIT1 Protein Depletion Modifies Endothelial Cell Behavior via Increased Vascular Endothelial Growth Factor (VEGF) Signaling [PDF]

Journal of Biological Chemistry, 2014
Disruption of endothelial cell-cell contact is a key event in many cardiovascular diseases and a characteristic of pathologically activated vascular endothelium. The CCM (cerebral cavernous malformation) family of proteins (KRIT1 (Krev-interaction trapped 1), PDCD10, and CCM2) are critical regulators of endothelial cell-cell contact and vascular ...
Íngrid H Sarelius, Angela Glading
exaly   +5 more sources

KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins [PDF]

Antioxidants, 2019
Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting therapies.
Laura Cianfruglia, Andrea Perrelli, Claudia Fornelli, Alessandro Magini, Stefania Gorbi, Anna Maria Salzano, Cinzia Antognelli, Francesca Retta, Valerio Benedetti, Paola Cassoni, Carla Emiliani, Giovanni Principato, Andrea Scaloni, Tatiana Armeni, Saverio Francesco Retta   +14 more
doaj   +7 more sources

Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1 [PDF]

Journal of Cell Science, 2021
ABSTRACT KRIT1 is a scaffolding protein that regulates multiple molecular mechanisms, including cell–cell and cell–matrix adhesion, and redox homeostasis and signaling. However, rather little is known about how KRIT1 is itself regulated.
Elisa De Luca, Andrea Perrelli, Harsha Swamy   +2 more
exaly   +4 more sources

Contribution of protein–protein interactions to the endothelial-barrier-stabilizing function of KRIT1 [PDF]

Journal of Cell Science, 2022
ABSTRACT Krev-interaction trapped protein 1 (KRIT1) is an endothelial scaffold protein that promotes adherens junction (AJ) stability. The precise mechanism by which KRIT1 promotes barrier stabilization is unclear. We tested the ability of a panel of KRIT1 constructs containing mutations that inhibit Rap1 binding, ICAP1α binding, disrupt
Harsha Swamy, Angela Glading
exaly   +3 more sources

Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

FASEB BioAdvances, 2021
The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1–KRIT1 protein complex that establishes and maintains junctional integrity.
Miguel Alejandro Lopez‐Ramirez, Sara McCurdy, Wenqing Li, Mark K. Haynes, Preston Hale, Karol Francisco, Killian Oukoloff, Matthew Bautista, Chelsea H.J. Choi, Hao Sun, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras   +14 more
doaj   +2 more sources

Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression [PDF]

Nature Communications
Regulated expression of Kruppel like factor (KLF) transcription factors is essential for normal maintenance of endothelial cells, but loss of either K-Rev interaction trapped 1 (KRIT1) or cerebral cavernous malformations 2 (CCM2) proteins results in ...
Clotilde Huet-Calderwood, Oriana S. Fisher, Sreya Das, Valerie L. Su, Titus J. Boggon, David A. Calderwood   +5 more
doaj   +2 more sources

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation. [PDF]

Brain Behav
Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Zhu X, Yao Y, Yu T, Xiao X.
europepmc   +2 more sources

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22 [PDF]

Oncogene, 1997
Krev-1/rap1A is an evolutionarily conserved Ras-family GTPase whose cellular function remains unclear, but which has been proposed to function as a tumor suppressor gene, and may act as a Ras antagonist. To elucidate Krev-1 activity, we have used LexA-Krev-1 in a two-hybrid screen of a HeLa cell cDNA library.
Ilya G Serebriiskii, G Sonoda, Joseph R Testa   +2 more
exaly   +3 more sources

Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus [PDF]

Journal of Biological Chemistry, 2017
Binding of ICAP1 (integrin cytoplasmic domain-associated protein-1) to the cytoplasmic tails of β1 integrins inhibits integrin activation. ICAP1 also binds to KRIT1 (Krev interaction trapped-1), a protein whose loss of function leads to cerebral cavernous malformation, a cerebrovascular dysplasia occurring in up to 0.5% of the population. We previously
Bertrand Simon, David A Calderwood
exaly   +3 more sources