Krüppel-like Factor 2 (KLF2) in Immune Cell Migration [PDF]
Vaccines, 2021 Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell
Jens Wittner, Wolfgang Schuh
exaly +7 more sources
KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription [PDF]
Scientific ReportsKruppel-like factor 2 (KLF2) acts as an essential modulator of adipogenesis; nevertheless, the exact molecular pathways governing its role remain uncharacterized. This investigation characterized the expression profile of KLF2 in human adipose tissue and
Tingting Zhang +6 more
doaj +5 more sources
Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells [PDF]
Cells, 2022 Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis.
Qi Zheng, Peng Teng, Xiaoyi Dai
exaly +4 more sources
The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy [PDF]
Biomedicines, 2022 Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent
Siarhei A. Dabravolski +5 more
doaj +3 more sources
KLF2 is a clinical diagnostic and treatment biomarker of breast cancer
Frontiers in Cell and Developmental Biology, 2023 Background: As a highly prevalent malignancy among women worldwide, breast cancer, remains a critical public health issue necessitating the development of novel therapeutics and biomarkers.
Ya-Zhao Li +10 more
doaj +3 more sources
Journal of Pathology: Clinical Research, 2023 Krüppel‐like factor 2 (KLF2) belongs to the zinc finger family and is thought to be a tumor suppressor gene due to its low expression in various cancer types.
Jia Li +3 more
exaly +2 more sources
Journal of Obstetrics and Gynaecology, 2023 Endometrial cancer (EC) is the most common gynaecologic malignancy. This study was to explore the role of kruppel-like factor 2 (KLF2) in EC cell behaviours. The expression of KLF2 in EC and its correlation with NPM1 were first predicted on the database.
Xiyun Cheng +2 more
exaly +2 more sources
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy [PDF]
Cells, 2022 Kruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events.
Eunjin Bae +8 more
doaj +3 more sources
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow [PDF]
Cell & BioscienceMesenchymal stem cells (MSCs) have many uses in tissue engineering and clinical applications. However, maintaining their stemness during in vitro expansion is challenging.
Zhiyuan Gong +7 more
doaj +2 more sources
Krüppel-like Factor 2 (KLF2) in the Regulation of Lipid Accumulation, ROS, and Mitochondrial Functions During Foam Cell Formation in RAW264.7 Cells [PDF]
BiologyFoam cell formation, a hallmark of early atherosclerotic lesion development, is closely associated with mitochondrial dysfunction and excessive reactive oxygen species (ROS) production.
Md Sariful Islam Howlader +4 more
doaj +2 more sources