Results 1 to 10 of about 12,659 (217)
Krüppel-like Factor 2 (KLF2) in Immune Cell Migration [PDF]
Vaccines, 2021 Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell
Wolfgang Schuh, Jens Wittner
exaly +9 more sources
Journal of Pathology: Clinical Research, 2023 Krüppel‐like factor 2 (KLF2) belongs to the zinc finger family and is thought to be a tumor suppressor gene due to its low expression in various cancer types.
Jia Li +3 more
exaly +3 more sources
Journal of Obstetrics and Gynaecology, 2023 Endometrial cancer (EC) is the most common gynaecologic malignancy. This study was to explore the role of kruppel-like factor 2 (KLF2) in EC cell behaviours. The expression of KLF2 in EC and its correlation with NPM1 were first predicted on the database.
Xiyun Cheng +2 more
exaly +3 more sources
KLF2 is a clinical diagnostic and treatment biomarker of breast cancer
Frontiers in Cell and Developmental Biology, 2023 Background: As a highly prevalent malignancy among women worldwide, breast cancer, remains a critical public health issue necessitating the development of novel therapeutics and biomarkers.
Ya-Zhao Li +10 more
doaj +3 more sources
Cells, 2022 Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis.
Liang Ma, Hai Song, Weiguo Zou
exaly +3 more sources
KLF2 alleviates sepsis-induced acute kidney injury via the lncRNA GAS6-AS2/GOLPH3 axis [PDF]
BMC NephrologyBackground Sepsis-associated acute kidney injury (SA-AKI) is a leading cause of organ failure with high morbidity and mortality. We aimed to investigate the effect and mechanism of KLF2 on SA-AKI cell model, trying to provide novel knowledge for AKI ...
Wei Feng +5 more
doaj +2 more sources
Redox Biology, 2020 To define the regulatory role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cell (DPSC)s, herein, we show that the levels of KLF2 and autophagy-related molecules were significantly increased in ...
Hiranmoy Das +2 more
exaly +3 more sources
Krüppel-like factor 2 is required for normal mouse cardiac development. [PDF]
PLoS ONE, 2013 Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death
Aditi R Chiplunkar +7 more
doaj +1 more source
A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence
Frontiers in Cell and Developmental Biology, 2022 Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej +4 more
doaj +1 more source
Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation
Cell Reports, 2023 Summary: Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator ...
Tzu-Yu Shao +15 more
doaj +1 more source