Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages. [PDF]
PLoS ONE, 2015 Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells. Because KLF2 is known to exert anti-inflammatory effects and inhibit the pro-inflammatory activation of ...
Shaolin He +3 more
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Regulation of Tfr cell differentiation by KLF2 Mediated by KLF2 mediated Blipm1 and T-Bet expression [PDF]
Journal of Genetics and Molecular Biology, 2020 In normal circumstances, the germinal centre reaction (GC) in response to infectious agent results in production of antibodies (Ab) preventing aberrant inflammation and autoimmune diseases. In germinal centre the production of Ab is triggered by T follicular helper (Tfh) cells.
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Cellular Physiology and Biochemistry, 2017 Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process.
Yuan Yuan, Honglue Tan, Pengyi Dai
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]
, 2017 Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina +18 more
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Klf2 Is an Essential Regulator of Vascular Hemodynamic Forces In Vivo [PDF]
Developmental Cell, 2006 Hemodynamic responses that control blood pressure and the distribution of blood flow to different organs are essential for survival. Shear forces generated by blood flow regulate hemodynamic responses, but the molecular and genetic basis for such regulation is not known.
Lee, John S. +14 more
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KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype. [PDF]
, 2014 To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent inactivating mutations in Kruppel-like factor 2 (KLF2), a gene whose deficiency was previously shown to ...
Ashton-Key, M +22 more
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KLF2 and KLF4 control endothelial identity and vascular integrity [PDF]
JCI Insight, 2017 Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized.
Panjamaporn, Sangwung +17 more
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The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.
PLoS ONE, 2013 Krüppel-like factor 2 (KLF2) is a transcription factor that is highly expressed in quiescent T lymphocytes and downregulated in effector T cells. We now show that antigen receptor engagement downregulates KLF2 expression in a graded response determined ...
Gavin C Preston +4 more
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Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
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Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]
, 2012 The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J. +2 more
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