Results 31 to 40 of about 12,659 (217)

KLF2 regulates osteoblast differentiation by targeting of Runx2 [PDF]

Laboratory Investigation, 2019
Osteoblast differentiation plays a critical role in bone formation and maintaining balance in bone remodeling. Runt-related transcription factor 2 (Runx2) is a central transcription factor regulating osteoblast differentiation and promoting bone mineralization.
Zhenyang, Hou, Zhen, Wang, Yunxia, Tao, Jiaxiang, Bai, Binqing, Yu, Jining, Shen, Houyi, Sun, Long, Xiao, Yaozeng, Xu, Jun, Zhou, Zhirong, Wang, Dechun, Geng   +11 more
openaire   +2 more sources

The FBW7-KLF2 axis regulates endothelial functions [PDF]

Cell Research, 2013
FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
Yongchao, Zhao, Yi, Sun
openaire   +2 more sources

Regulation of Tfr cell differentiation by KLF2 Mediated by KLF2 mediated Blipm1 and T-Bet expression [PDF]

Journal of Genetics and Molecular Biology, 2020
In normal circumstances, the germinal centre reaction (GC) in response to infectious agent results in production of antibodies (Ab) preventing aberrant inflammation and autoimmune diseases. In germinal centre the production of Ab is triggered by T follicular helper (Tfh) cells.
openaire   +1 more source

Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13

Cellular Physiology and Biochemistry, 2017
Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process.
Yuan Yuan, Honglue Tan, Pengyi Dai
doaj   +1 more source

Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells

Scientific Reports, 2017
The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis.
Yanni Xu, Peng Liu, Suowen Xu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin   +6 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation [PDF]

Advanced science
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Zheng W, Yu S, Chen L, Ma J, Shen P, Yu C, Xin X, Shen Q, Chen J, Ke S, Liu H, Jiang X, Qi R, Yan J, Li J, Choi J, Lu Y, Zhao Y.   +17 more
europepmc   +2 more sources

KLF2 and KLF4 control endothelial identity and vascular integrity [PDF]

JCI Insight, 2017
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here,
Panjamaporn Sangwung, Guangjin Zhou, Lalitha Nayak, E. Ricky Chan, Sandeep Kumar, Dong-Won Kang, Rongli Zhang, Xudong Liao, Yuan Lu, Keiki Sugi, Hisashi Fujioka, Hong Shi, Stephanie D. Lapping, Chandra C. Ghosh, Sarah J. Higgins, Samir M. Parikh, Hanjoong Jo, Mukesh K. Jain   +17 more
openaire   +2 more sources

The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.

PLoS ONE, 2013
Krüppel-like factor 2 (KLF2) is a transcription factor that is highly expressed in quiescent T lymphocytes and downregulated in effector T cells. We now show that antigen receptor engagement downregulates KLF2 expression in a graded response determined ...
Gavin C Preston, Carmen Feijoo-Carnero, Nick Schurch, Victoria H Cowling, Doreen A Cantrell   +4 more
doaj   +1 more source

IKKβ regulates endothelial thrombomodulin in a Klf2‐dependent manner [PDF]

Journal of Thrombosis and Haemostasis, 2014
Endothelial thrombomodulin (TM) is critically involved in anticoagulation, anti-inflammation, cytoprotection and normal fetal development. Tumor necrosis factor alpha (TNFα) suppresses TM expression.TNFα has been shown to down-regulate TM partly via activation of nuclear factor kappa B (NF-κB).
R, Pathak, L, Shao, S M, Chafekar, W, Feng, U, Ponnappan, L M, Fink, D, Zhou, M, Hauer-Jensen   +7 more
openaire   +2 more sources

Homeostatic effects of exosomal KLF2 microRNAs: implications for treatment of pulmonary hypertension [PDF]

, 2020
Background. Pulmonary arterial hypertension (PAH) is a severe disorder leading to right heart failure. Recently identified disabling mutations in shear stress-activated transcription factor Krüppel-like factor 2 (KLF2) in hereditary PAH suggest its ...
Sindi, Hebah Adel
core   +1 more source