Results 31 to 40 of about 11,628 (203)
The FBW7-KLF2 axis regulates endothelial functions [PDF]
Cell Research, 2013 FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
Yongchao, Zhao, Yi, Sun
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Regulation of Tfr cell differentiation by KLF2 Mediated by KLF2 mediated Blipm1 and T-Bet expression [PDF]
Journal of Genetics and Molecular Biology, 2020 In normal circumstances, the germinal centre reaction (GC) in response to infectious agent results in production of antibodies (Ab) preventing aberrant inflammation and autoimmune diseases. In germinal centre the production of Ab is triggered by T follicular helper (Tfh) cells.
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Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages. [PDF]
PLoS ONE, 2015 Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells. Because KLF2 is known to exert anti-inflammatory effects and inhibit the pro-inflammatory activation of ...
Shaolin He +3 more
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, 2022 Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal types of urologic cancer. With low survival rates among patients in advanced stages of disease, and increasing rate of morbidity and mortality worldwide, novel therapeutic ...
Jiantao Xiao (2140309) +6 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process.
Yuan Yuan, Honglue Tan, Pengyi Dai
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Klf2 Is an Essential Regulator of Vascular Hemodynamic Forces In Vivo [PDF]
Developmental Cell, 2006 Hemodynamic responses that control blood pressure and the distribution of blood flow to different organs are essential for survival. Shear forces generated by blood flow regulate hemodynamic responses, but the molecular and genetic basis for such regulation is not known.
Lee, John S. +14 more
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KLF2 and KLF4 control endothelial identity and vascular integrity [PDF]
JCI Insight, 2017 Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here,
Panjamaporn Sangwung +17 more
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Functional analysis of KLF2 and its lymphoma-derived mutants
, 2022 Splenic marginal zone lymphoma is a low-grade B cell neoplasm, which originates from the splenic marginal zone B cells. Whole exome studies show recurrent somatic mutations in KLF2, and genes in the NOTCH2, NF-κB, BCR and TLR signalling pathways ...
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IKKβ regulates endothelial thrombomodulin in a Klf2‐dependent manner [PDF]
Journal of Thrombosis and Haemostasis, 2014 Endothelial thrombomodulin (TM) is critically involved in anticoagulation, anti-inflammation, cytoprotection and normal fetal development. Tumor necrosis factor alpha (TNFα) suppresses TM expression.TNFα has been shown to down-regulate TM partly via activation of nuclear factor kappa B (NF-κB).
R, Pathak +7 more
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KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation [PDF]
The Journal of Experimental Medicine, 2004 The vascular endothelium is a critical regulator of vascular function. Diverse stimuli such as proinflammatory cytokines and hemodynamic forces modulate endothelial phenotype and thereby impact on the development of vascular disease states. Therefore, identification of the regulatory factors that mediate the effects of these stimuli on endothelial ...
SenBanerjee, Sucharita +13 more
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