Results 21 to 30 of about 17,085 (238)

Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 [PDF]

Frontiers in Immunology, 2020
Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of ...
Daniela Rolph, Hiranmoy Das
openaire   +3 more sources

MiRrored Regulation of KLF2 and KLF4 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
openaire   +2 more sources

Krüppel-like factor 2 is required for normal mouse cardiac development. [PDF]

PLoS ONE, 2013
Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death
Aditi R Chiplunkar, Tina K Lung, Yousef Alhashem, Benjamin A Koppenhaver, Fadi N Salloum, Rakesh C Kukreja, Jack L Haar, Joyce A Lloyd   +7 more
doaj   +1 more source

A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence

Frontiers in Cell and Developmental Biology, 2022
Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej, Cassondra Axen, Anita Wary, Richard D. Minshall, Kishore K. Wary   +4 more
doaj   +1 more source

KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3. [PDF]

Proc Natl Acad Sci U S A
DePauw TA, Gai K, Shen J, Maurice NJ, Rhee KH, Valente WJ, O'Connor CH, Cui W, Peng C, Jameson SC.   +9 more
europepmc   +2 more sources

KLF2 regulates osteoblast differentiation by targeting of Runx2 [PDF]

Laboratory Investigation, 2019
Osteoblast differentiation plays a critical role in bone formation and maintaining balance in bone remodeling. Runt-related transcription factor 2 (Runx2) is a central transcription factor regulating osteoblast differentiation and promoting bone mineralization.
Zhenyang, Hou, Zhen, Wang, Yunxia, Tao, Jiaxiang, Bai, Binqing, Yu, Jining, Shen, Houyi, Sun, Long, Xiao, Yaozeng, Xu, Jun, Zhou, Zhirong, Wang, Dechun, Geng   +11 more
openaire   +2 more sources

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation

Cell Reports, 2023
Summary: Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator ...
Tzu-Yu Shao, Tony T. Jiang, Joseph Stevens, Abigail E. Russi, Ty D. Troutman, Anas Bernieh, Giang Pham, John J. Erickson, Emily M. Eshleman, Theresa Alenghat, Stephen C. Jameson, Kristin A. Hogquist, Casey T. Weaver, David B. Haslam, Hitesh Deshmukh, Sing Sing Way   +15 more
doaj   +1 more source

Protective Role for Myeloid Specific KLF2 in Atherosclerosis [PDF]

Circulation Research, 2012
In this issue of Circulation Research , Lingrel and colleagues1 describe the phenotype of myeloid-specific Klf2 knockout mice. Although this transcription factor has long been known to be involved in protection from atherosclerosis, the cell type responsible was not clear.
Iftach, Shaked, Klaus, Ley
openaire   +2 more sources

KLF2 Inhibits Chicken Preadipocyte Differentiation at Least in Part via Directly Repressing PPARγ Transcript Variant 1 Expression

Frontiers in Cell and Developmental Biology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Bolin Ning, Bolin Ning, Bolin Ning, Fang Mu, Fang Mu, Fang Mu, Xin You, Xin You, Xin You, Yaqi Guo, Yaqi Guo, Yaqi Guo, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +28 more
doaj   +1 more source

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. [PDF]

, 2014
Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription ...
ABURATANI Hiroyuki, ARUGA Hirofumi, ASANUMA Akimune, DOI Takeshi, DONG Shoulian, ENDO Akira, HAMAKUBO Takao, IHARA Sigeo, INOUE Tsuyoshi, IWANARI Hiroko, KANEKI Kiyomi, KANKI Yasuharu, KAWAMURA Takeshi, KIMURA Hiroshi, KOBAYASHI Mika, KODAMA Tatsuhiko, KOHRO Takahide, LI Guoliang, MAEJIMA Takashi, MIMURA Imari, MINAMI Takashi, NANGAKU Masaomi, NOZAKI Naohito, OHTA Yoshihiro, POH Huay Mei, RUAN Xiaoan, RUAN Yijun, SAKAI Juro, SHIBATA Haruki, STEVENS Junko F, SUEHIRO Jun-ichi, SUGIYAMA Akira, TAGUCHI Akashi, TANABE Hideyuki, TANABE Sohei, TANAKA Toshiya, TSUTSUMI Shuichi, WADA Youichiro, YAMAMOTO Kazuki, YAMAMOTO Shogo, YOSHINAKA Yasunobu   +40 more
core   +20 more sources