Results 21 to 30 of about 12,659 (217)
Journal of Lipid ResearchLiver steatosis is a common metabolic disorder resulting from imbalanced lipid metabolism, which involves various processes such as de novo lipogenesis, fatty acid uptake, fatty acid oxidation, and VLDL secretion.
Yuhong Huang +5 more
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Transcriptional regulation of endothelial KLF2 in vascular development
, 2022 The development of a functional vascular system is critically dependent on shear stress, a hemodynamic force exerted onto the vascular endothelium by flowing blood. Krüppel-like factor 2 (KLF2) is the central transcriptional regulator of the endothelial shear stress response, yet the mechanisms by which shear stress signalling controls KLF2 expression ...
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Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae
Journal of Cardiothoracic SurgeryBackground Streptococcus pneumoniae (Spn) is a major causative agent of pneumonia, which can disseminate to the bloodstream and brain. Pneumonia remains a leading cause of death among children aged 1–59 months worldwide.
Xiaoshuang Li, Weihua Xu, Tao Jing
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MiRrored Regulation of KLF2 and KLF4 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
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Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 [PDF]
Frontiers in Immunology, 2020 Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of ...
Daniela Rolph, Hiranmoy Das
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Papel del factor de transcripción Kruppel-like factor 2 en la disfunción endotelial hepática asociada a la hipertensión portal y al daño por isquemia y reperfusión [PDF]
, 2011 El endotelio disfuncional presenta, entre otras caracteristicas, alteración en los mecanismos de vasodilatación, complicaciones trombóticas, disminución de la resistencia al estrés oxidativo, aumento de la expresión de moléculas de adhesión y de la ...
Russo, Lucia
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Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective [PDF]
Journal of Clinical Investigation, 2022 About 6 million adults in the United States have heart failure, and the mortality five years after diagnosis remains high at approximately 50%. Incomplete understanding of disease pathogenesis limits therapeutics, especially in the case of heart failure with preserved ejection fraction, a condition commonly associated with cardiac hypertrophy ...
Dario F. Riascos-Bernal +1 more
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Protective Role for Myeloid Specific KLF2 in Atherosclerosis [PDF]
Circulation Research, 2012 In this issue of Circulation Research , Lingrel and colleagues1 describe the phenotype of myeloid-specific Klf2 knockout mice. Although this transcription factor has long been known to be involved in protection from atherosclerosis, the cell type responsible was not clear.
Iftach, Shaked, Klaus, Ley
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Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages. [PDF]
PLoS ONE, 2015 Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells. Because KLF2 is known to exert anti-inflammatory effects and inhibit the pro-inflammatory activation of ...
Shaolin He +3 more
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Frontiers in Cell and Developmental Biology, 2021 Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui +28 more
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