Results 21 to 30 of about 11,628 (203)

KLF2 IS REQUIRED FOR NORMAL MOUSE CARDIOVASCULAR DEVELOPMENT

, 2013
VCU Theses and ...
Chiplunkar, Aditi Raghunath
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Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae

Journal of Cardiothoracic Surgery
Background Streptococcus pneumoniae (Spn) is a major causative agent of pneumonia, which can disseminate to the bloodstream and brain. Pneumonia remains a leading cause of death among children aged 1–59 months worldwide.
Xiaoshuang Li, Weihua Xu, Tao Jing
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Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective [PDF]

Journal of Clinical Investigation, 2022
About 6 million adults in the United States have heart failure, and the mortality five years after diagnosis remains high at approximately 50%. Incomplete understanding of disease pathogenesis limits therapeutics, especially in the case of heart failure with preserved ejection fraction, a condition commonly associated with cardiac hypertrophy ...
Dario F. Riascos-Bernal, Nicholas E.S. Sibinga   +1 more
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Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 [PDF]

Frontiers in Immunology, 2020
Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of ...
Daniela Rolph, Hiranmoy Das
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MiRrored Regulation of KLF2 and KLF4 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
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A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence

Frontiers in Cell and Developmental Biology, 2022
Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej, Cassondra Axen, Anita Wary, Richard D. Minshall, Kishore K. Wary   +4 more
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Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation

Cell Reports, 2023
Summary: Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator ...
Tzu-Yu Shao, Tony T. Jiang, Joseph Stevens, Abigail E. Russi, Ty D. Troutman, Anas Bernieh, Giang Pham, John J. Erickson, Emily M. Eshleman, Theresa Alenghat, Stephen C. Jameson, Kristin A. Hogquist, Casey T. Weaver, David B. Haslam, Hitesh Deshmukh, Sing Sing Way   +15 more
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KLF2 regulates osteoblast differentiation by targeting of Runx2 [PDF]

Laboratory Investigation, 2019
Osteoblast differentiation plays a critical role in bone formation and maintaining balance in bone remodeling. Runt-related transcription factor 2 (Runx2) is a central transcription factor regulating osteoblast differentiation and promoting bone mineralization.
Zhenyang, Hou, Zhen, Wang, Yunxia, Tao, Jiaxiang, Bai, Binqing, Yu, Jining, Shen, Houyi, Sun, Long, Xiao, Yaozeng, Xu, Jun, Zhou, Zhirong, Wang, Dechun, Geng   +11 more
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Protective Role for Myeloid Specific KLF2 in Atherosclerosis [PDF]

Circulation Research, 2012
In this issue of Circulation Research , Lingrel and colleagues1 describe the phenotype of myeloid-specific Klf2 knockout mice. Although this transcription factor has long been known to be involved in protection from atherosclerosis, the cell type responsible was not clear.
Iftach, Shaked, Klaus, Ley
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KLF2 Inhibits Chicken Preadipocyte Differentiation at Least in Part via Directly Repressing PPARγ Transcript Variant 1 Expression

Frontiers in Cell and Developmental Biology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Bolin Ning, Bolin Ning, Bolin Ning, Fang Mu, Fang Mu, Fang Mu, Xin You, Xin You, Xin You, Yaqi Guo, Yaqi Guo, Yaqi Guo, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +28 more
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