Results 41 to 50 of about 11,628 (203)

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins [PDF]

Developmental Cell, 2015
Mechanotransduction pathways are activated in response to biophysical stimuli during the development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive transcription factor Klf2a promotes VEGF-dependent angiogenesis. However, the means by which the Klf2a mechanotransduction pathway is regulated to prevent continuous ...
Renz, Marc, Otten, Cécile, Faurobert, Eva, Rudolph, Franziska, Zhu, Yuan, Boulday, Gweńola, Duchene, Johan, Mickoleit, Michaela, Dietrich, Ann-Christin, Ramspacher, Caroline, Steed, Emily, Manet-Dupé, Sandra, Benz, Alexander, Hassel, David, Vermot, Julien, Huisken, Jan, Tournier-Lasserve, Elisabeth, Felbor, Ute, Sure, Ulrich, Albiges-Rizo, Corinne, Abdelilah-Seyfried, Salim   +20 more
openaire   +4 more sources

Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity

Frontiers in Immunology, 2022
Krüppel-like factor 2 (KLF2) is a transcription factor with significant roles in development, maturation, differentiation, and proliferation of several cell types.
Nora Pernaa, Salla Keskitalo, Iftekhar Chowdhury, Antti Nissinen, Virpi Glumoff, Riikka Keski-Filppula, Riikka Keski-Filppula, Riikka Keski-Filppula, Juhani Junttila, Kari K. Eklund, Wenny Santaniemi, Sanna Siitonen, Mikko RJ. Seppänen, Paula Vähäsalo, Paula Vähäsalo, Paula Vähäsalo, Markku Varjosalo, Pirjo Åström, Timo Hautala   +18 more
doaj   +1 more source

MiR‐32‐5p promoted epithelial‐to‐mesenchymal transition of oral squamous cell carcinoma cells via regulating the KLF2/CXCR4 pathway

Kaohsiung Journal of Medical Sciences, 2022
Oral squamous cell carcinoma (OSCC) is one of the most common carcinomas of the oral cavity. However, the regulatory mechanisms on miR‐32‐5p remain poorly understood in OSCC.
Shi‐Yu Qin, Bo Li, Mei Chen, Ming‐Qun Qin, Ji‐Mu Liu, Qiu‐Li Lv   +5 more
doaj   +1 more source

The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy

Journal of Nanobiotechnology, 2022
Background Dilated cardiomyopathy (DCM) is one of the common causes of heart failure. Myocardial injury triggers an inflammatory response and recruits immune cells into the heart. High expression of Krüppel-like factor 2 (KLF2) in endothelial cells (ECs)
Wenfeng Zhang, Ziwei Chen, Shuaihua Qiao, Siyuan Chen, Hongyan Zheng, Xuan Wei, Qiaoling Li, Biao Xu, Wei Huang   +8 more
doaj   +1 more source

The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies. [PDF]

PLoS ONE, 2012
BACKGROUND: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear.
Ellen L van Agtmaal, Ruben Bierings, Bieuwke S Dragt, Thomas A Leyen, Mar Fernandez-Borja, Anton J G Horrevoets, Jan Voorberg   +6 more
doaj   +1 more source

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival [PDF]

Nature Communications, 2016
AbstractKDM3A is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been elucidated. Here we identify KDM3A–KLF2–IRF4 axis dependence in MM. Knockdown of KDM3A is toxic to MM cells in vitro and in vivo. KDM3A maintains expression of KLF2 and IRF4 through H3K9 demethylation, and knockdown of KLF2 triggers ...
Hiroto Ohguchi, Teru Hideshima, Manoj K. Bhasin, Gullu T. Gorgun, Loredana Santo, Michele Cea, Mehmet K. Samur, Naoya Mimura, Rikio Suzuki, Yu-Tzu Tai, Ruben D. Carrasco, Noopur Raje, Paul G. Richardson, Nikhil C. Munshi, Hideo Harigae, Takaomi Sanda, Juro Sakai, Kenneth C. Anderson   +17 more
openaire   +4 more sources

KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2

American Journal of Men's Health, 2019
KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown.
Binshuai Wang, Mingyuan Liu, Yimeng Song, Changying Li, Shudong Zhang, Lulin Ma   +5 more
doaj   +1 more source

Role of KLF2 in atrioventricular cushion development

The FASEB Journal, 2009
Krüppel like factors (KLFs) are transcription factors with important roles in development. KLF2 KO mice die by embryonic day 14.5 (E14.5) and exhibit heart failure and hemorrhaging. KLF2 is expressed in multiple tissues including erythroid and endothelial cells.
Jack L. Haar, Tina K. Lung, Aditi R. Chiplunkar, Joyce A. Lloyd   +3 more
openaire   +1 more source

The expression of Kruppel-like factor 2 in mice with collagen-induced arthritis and its role in the induction of nitric oxide synthase production

European Journal of Inflammation, 2020
Kruppel-like factor 2 (KLF2) is associated with acute and chronic inflammation. However, the role of KLF2 in rheumatoid arthritis (RA) remains unknown.
Donglei Wu, Xinye Wang, Shuaijun Xu, Wanjun Zhang, Shiyi Zeng, Chenghong Ni, Xinjing Luo, Guoju Lv   +7 more
doaj   +1 more source

Suberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundKruppel‐like factor 2 (KLF2) is an important zinc‐finger transcription factor that maintains endothelial homeostasis by its anti‐inflammatory, ‐thrombotic, ‐oxidative, and ‐proliferative effects in endothelial cells.
Yanni Xu, Suowen Xu, Peng Liu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin   +6 more
doaj   +1 more source