Results 41 to 50 of about 17,085 (238)

Klf2 Is an Essential Factor that Sustains Ground State Pluripotency [PDF]

Cell Stem Cell, 2014
The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways.
Yeo, Jia-Chi, Jiang, Jianming, Tan, Zi-Ying, Yim, Guo-Rong, Ng, Jia-Hui, Göke, Jonathan, Kraus, Petra, Liang, Hongqing, Gonzales, Kevin Andrew Uy, Chong, Han-Chung, Tan, Cheng-Peow, Lim, Yee-Siang, Tan, Nguan-Soon, Lufkin, Thomas, Ng, Huck-Hui   +14 more
openaire   +4 more sources

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]

, 2009
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates, A. F Hurlstone, A. F Moorman, A. G Passerini, A. M Malek, A. R Brooks, A. S Forouhar, Arian S. Forouhar, B. C Groenendijk, B. C Groenendijk, C Ethier, C Hahn, C. H Kim, D Beis, D. J Milan, David Wu, Diane Plummer, E Berdougo, E. C Walsh, E. J Armstrong, G Bendig, G Garcia-Cardena, G. B Atkins, G. P Sorescu, H Kokubo, H. J Auman, Hiroshi Hamada, J Alexander, J Pan, J. L Galloway, J. N Chen, J. R Hove, J. S Lee, Julien Vermot, K. M Parmar, L. A Timmerman, M Liebling, M Xin, M Yamada, Michael Liebling, Morteza Gharib, N Sultana, N. C Chi, N. C Chi, P. J Scherz, R. D Kortschak, R. J Dekker, R. J Dekker, S Isogai, S Quintin, S. M McCormick, S. M Meadows, S. W Jin, Scott E. Fraser, T Bartman, T Bartman, T Lecuit, T Lecuit, T. R Cummins, X. L Wang, Y Fung   +60 more
core   +5 more sources

IKKβ regulates endothelial thrombomodulin in a Klf2‐dependent manner [PDF]

Journal of Thrombosis and Haemostasis, 2014
Endothelial thrombomodulin (TM) is critically involved in anticoagulation, anti-inflammation, cytoprotection and normal fetal development. Tumor necrosis factor alpha (TNFα) suppresses TM expression.TNFα has been shown to down-regulate TM partly via activation of nuclear factor kappa B (NF-κB).
R, Pathak, L, Shao, S M, Chafekar, W, Feng, U, Ponnappan, L M, Fink, D, Zhou, M, Hauer-Jensen   +7 more
openaire   +2 more sources

KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation [PDF]

The Journal of Experimental Medicine, 2004
The vascular endothelium is a critical regulator of vascular function. Diverse stimuli such as proinflammatory cytokines and hemodynamic forces modulate endothelial phenotype and thereby impact on the development of vascular disease states. Therefore, identification of the regulatory factors that mediate the effects of these stimuli on endothelial ...
SenBanerjee, Sucharita, Lin, Zhiyong, Atkins, G. Brandon, Greif, Daniel M., Rao, Ravi M., Kumar, Ajay, Feinberg, Mark W., Chen, Zhiping, Simon, Daniel I., Luscinskas, F. William, Michel, Thomas M., Gimbrone, Michael A., García-Cardeña, Guillermo, Jain, Mukesh K.   +13 more
openaire   +2 more sources

Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity

Frontiers in Immunology, 2022
Krüppel-like factor 2 (KLF2) is a transcription factor with significant roles in development, maturation, differentiation, and proliferation of several cell types.
Nora Pernaa, Salla Keskitalo, Iftekhar Chowdhury, Antti Nissinen, Virpi Glumoff, Riikka Keski-Filppula, Riikka Keski-Filppula, Riikka Keski-Filppula, Juhani Junttila, Kari K. Eklund, Wenny Santaniemi, Sanna Siitonen, Mikko RJ. Seppänen, Paula Vähäsalo, Paula Vähäsalo, Paula Vähäsalo, Markku Varjosalo, Pirjo Åström, Timo Hautala   +18 more
doaj   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins [PDF]

Developmental Cell, 2015
Mechanotransduction pathways are activated in response to biophysical stimuli during the development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive transcription factor Klf2a promotes VEGF-dependent angiogenesis. However, the means by which the Klf2a mechanotransduction pathway is regulated to prevent continuous ...
Renz, Marc, Otten, Cécile, Faurobert, Eva, Rudolph, Franziska, Zhu, Yuan, Boulday, Gweńola, Duchene, Johan, Mickoleit, Michaela, Dietrich, Ann-Christin, Ramspacher, Caroline, Steed, Emily, Manet-Dupé, Sandra, Benz, Alexander, Hassel, David, Vermot, Julien, Huisken, Jan, Tournier-Lasserve, Elisabeth, Felbor, Ute, Sure, Ulrich, Albiges-Rizo, Corinne, Abdelilah-Seyfried, Salim   +20 more
openaire   +4 more sources

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy

Journal of Nanobiotechnology, 2022
Background Dilated cardiomyopathy (DCM) is one of the common causes of heart failure. Myocardial injury triggers an inflammatory response and recruits immune cells into the heart. High expression of Krüppel-like factor 2 (KLF2) in endothelial cells (ECs)
Wenfeng Zhang, Ziwei Chen, Shuaihua Qiao, Siyuan Chen, Hongyan Zheng, Xuan Wei, Qiaoling Li, Biao Xu, Wei Huang   +8 more
doaj   +1 more source

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources