Results 61 to 70 of about 17,085 (238)

Role of KLF2 in atrioventricular cushion development

The FASEB Journal, 2009
Krüppel like factors (KLFs) are transcription factors with important roles in development. KLF2 KO mice die by embryonic day 14.5 (E14.5) and exhibit heart failure and hemorrhaging. KLF2 is expressed in multiple tissues including erythroid and endothelial cells.
Jack L. Haar, Tina K. Lung, Aditi R. Chiplunkar, Joyce A. Lloyd   +3 more
openaire   +1 more source

Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design. [PDF]

, 2020
Purpose of review:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts.Recent findings:Investigations using animal models and human ...
Ferre, April L, Kiniry, Brenna E, Shacklett, Barbara L   +2 more
core  

Suberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundKruppel‐like factor 2 (KLF2) is an important zinc‐finger transcription factor that maintains endothelial homeostasis by its anti‐inflammatory, ‐thrombotic, ‐oxidative, and ‐proliferative effects in endothelial cells.
Yanni Xu, Suowen Xu, Peng Liu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin   +6 more
doaj   +1 more source

microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis

Adipocyte, 2021
Extracellular vesicles (EVs) are nano-sized vesicles secreted actively by numeorus cells and have fundamental roles in intercellular communication through shuttling functional RNAs.
Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yang   +4 more
doaj   +1 more source

In Silico Modeling of Shear-Stress-Induced Nitric Oxide Production in Endothelial Cells through Systems Biology [PDF]

, 2012
Nitric oxide (NO) produced by vascular endothelial cells is a potent vasodilator and an antiinflammatory mediator. Regulating production of endothelial-derived NO is a complex undertaking, involving multiple signaling and genetic pathways that are ...
Ayyadurai, V. A. Shiva, Dewey, C. Forbes, Dewey, C. Forbes, Garcia-Cardena, Guillermo, Koo, Andrew Jia-An, Nordsletten, David, Umeton, Renato, Yankama, Beracah   +7 more
core   +1 more source

Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36

Journal of Lipid Research, 2014
The Krppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, apoptosis, development, and responses to external stress.
Jin-Lian Chen, Xiao-Jie Lu, Kai-Lin Zou, Kun Ye   +3 more
doaj   +1 more source

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. [PDF]

, 2018
Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration.
Cai, Tao, Dai, Huaping, Huang, Huanwei, Li, Jiao, Li, Juan, Tang, Nan, Tang, Zan, Wang, Fengchao, Wang, Yanjie, Wang, Zheng, Yu, Yuanyuan, Zhang, Chengwei   +11 more
core   +1 more source

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +1 more source

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]

, 2016
BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K, Hashimoto, Y, Ichikawa, T, Ichinose, M, Kikuchi, T, Koarai, A, Numakura, T, Okazaki, T, Onodera, K, Sato, K, Sugiura, H, Tamada, T, Tanaka, R, Yamada, M, Yanagisawa, S   +14 more
core   +2 more sources

miR‐92a‐3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis

Thoracic Cancer, 2022
Background Breast cancer remains the most common malignancy in females around the world. Recently, a growing number of studies have focused on gene dysregulation.
Zhi‐Hao Yu, Zhao‐Hui Chen, Guang‐Lei Zhou, Xue‐Jie Zhou, Hai‐Yan Ma, Yue Yu, Xin Wang, Xu‐Chen Cao   +7 more
doaj   +1 more source