Results 61 to 70 of about 12,659 (217)

KLF2 dependency of AQP1 expression.

, 2016
(A, B) Expression of KLF2 was induced in HUVEC by laminar flow (shear), lentiviral transduction (KLF2) or incubation with atorvastatin (statin). mRNA levels were determined by semi-quantitative RT-PCR for AQP1 (A) and eNOS (B), normalized to P0 and shown
Ruud D. Fontijn (725564), Oscar L. Volger (804629), Anuradha Doddaballapur (840992), Thomas Leyen (840993), Josefien M. Baggen (725563), Tineke C. van der Pouw-Kraan (840991), Anton J. G. Horrevoets (159105), Reinier A. Boon (840994)   +7 more
core   +1 more source

KLF2 reduces dexamethasone-induced injury to growth plate chondrocytes by inhibiting the Runx2-mediated PI3K/AKT and ERK signalling pathways

Autoimmunity, 2023
Dexamethasone (Dex) is a type of glucocorticoid drug. Long term use can induce growth plate chondrocytes (GPCs) apoptosis, impair differentiation, and inhibit cell proliferation and bone growth.
Yulong Ma, Tao Peng, Xudong Yao, Chaonan Sun, Xiaowei Wang   +4 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

The role of CCM proteins inβ1 Integrin-Klf2-Egfl7-mediated angiogenesis [PDF]

, 2015
Angiogenese ist entscheidend für die meisten physiologische Prozesse und viele pathologische Umstände. Dabei wird Angiogenese durch die Interaktion zwischen der extrazellulären Matrix (ECM) und endothelialen Zellen reguliert. Während der kardiovaskulären
Renz, Marc Andreas
core   +1 more source

miR‐92a‐3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis

Thoracic Cancer, 2022
Background Breast cancer remains the most common malignancy in females around the world. Recently, a growing number of studies have focused on gene dysregulation.
Zhi‐Hao Yu, Zhao‐Hui Chen, Guang‐Lei Zhou, Xue‐Jie Zhou, Hai‐Yan Ma, Yue Yu, Xin Wang, Xu‐Chen Cao   +7 more
doaj   +1 more source

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus

Arthritis Research & Therapy
Background Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE.
Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo, Junming Li   +6 more
doaj   +1 more source

Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis

Cells, 2019
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease, and Krüppel-like factor 2 (KLF2) regulates immune cell activation and function.
Manjusri Das, Moonmoon Deb, Dipranjan Laha, Matthew Joseph, Suman Kanji, Reeva Aggarwal, O. Hans Iwenofu, Vincent J. Pompili, Wael Jarjour, Hiranmoy Das   +9 more
doaj   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

OPG content of mock- or KLF2-transduced BOECs.

, 2012
(A) Immunofluorescence image showing co-localization of OPG (green) and VWF (red) in both mock- and KLF2-tranduced BOECs. Nuclei were stained using DAPI (blue).
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source