Results 81 to 90 of about 11,628 (203)
CD8+ Tissue‐Resident Memory T Cells in Health and Disease
MedComm, Volume 7, Issue 7, July 2026.CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai +13 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
The Role of the Transcription Factor KLF2 in Vascular Development and Disease
, 2014 The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of ...
Novodvorsky, P., Chico, T.J.A.
openaire +3 more sources
E10.5 FVB/N KLF2−/− but not mix KLF2−/− embryos have erythroid cells outside of the dorsal aortas.
, 2013 (A) is a light micrograph (100X) of the FVB/N WT E10.5 dorsal aortas (DA). Erythroid cells (Ery) are found only within the aortas. (B) FVB/N KLF2−/− have a number of erythroid cells in tissue surrounding the DA.
Joyce A. Lloyd (282148) +7 more
core +1 more source
Homeostatic effects of exosomal KLF2 microRNAs: implications for treatment of pulmonary hypertension [PDF]
, 2020 Background. Pulmonary arterial hypertension (PAH) is a severe disorder leading to right heart failure. Recently identified disabling mutations in shear stress-activated transcription factor Krüppel-like factor 2 (KLF2) in hereditary PAH suggest its ...
Sindi, Hebah Adel
core +1 more source
The Journal of Clinical Hypertension, Volume 28, Issue 7, July 2026.ABSTRACT This prospective observational study investigated whether systolic blood pressure variability (SBPV) during the transitional care period predicts long‐term outcomes after coronary artery bypass grafting (CABG). We enrolled 120 consecutive patients undergoing isolated CABG between 2020 and 2024 in a structured Transitional Care Service System ...
Pujuan Liu +7 more
wiley +1 more source
Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1 [PDF]
Molecular Immunology, 2008 We have shown previously that dipeptidyl peptidase 2 (DPP2) activity is essential for the survival of quiescent, but not activated, lymphocytes. The specific requirement of DPP2 activity for non-dividing cells is indicative of cell cycle specific regulation of this gene product.
Pradeep, Bista +3 more
openaire +2 more sources
Rapamycin induced mRNA and protein expression of KLF2 in HUVECs.
, 2013 Rapamycin was added to HUVECs at concentrations of 2, 20, 200 and 2000 ng/ml for 24 and 48 hours. KLF2 was assessed by real-time PCR, western blot and immunofluorescence assays. Each bar represented the mean±SD (n = 3).
Qian Ma (69668) +6 more
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer +12 more
wiley +1 more source
KLF2 binding to the AQP1 promoter.
, 2016 HUVECs were transduced with control virus (white) or lentivirus encoding V5-tagged KLF2 (black). Immunoprecipitation was performed using an anti-V5 tag antibody.
Ruud D. Fontijn (725564) +7 more
core +1 more source