Results 81 to 90 of about 17,085 (238)

Comprehensive analysis of KLF2 as a prognostic biomarker associated with fibrosis and immune infiltration in advanced hepatocellular carcinoma

BMC Bioinformatics, 2023
Purpose Most Hepatocellular carcinoma (HCC) patients are in advanced or metastatic stage at the time of diagnosis. Prognosis for advanced HCC patients is dismal.
Xue-Qin Chen, Jie Ma, Di Xu, Zuo-Lin Xiang   +3 more
doaj   +1 more source

Effect of altered haemodynamics on the developing mitral valve in chick embryonic heart [PDF]

, 2017
Intracardiac haemodynamics is crucial for normal cardiogenesis, with recent evidence showing valvulogenesis is haemodynamically dependent and inextricably linked with shear stress.
Abdelwahid, Abdelwahid, Banerjee, Ben-Shachar, Butcher, Butcher, Cai, Cai, Chandra, Chester, Chivukula, Clark, Clark, Combs, de Lange, de Vlaming, Delling, Dina, England, Garg, Greenhouse, Groenendijk, Groenendijk, Groenendijk, Hall, Hamburger, Heckel, Henderson, Hendrix, Hinton, Hinton, Hoersch, Hogers, Hove, Imanaka-Yoshida, Inai, Jiao, Kar Lai Pang, Keller, Kii, Kruithof, Lakkis, Lin, Lincoln, Lincoln, Lindsey, MacGrogan, Martinsen, Matsumaru, Matthew Parnall, Mayhew, McQuinn, Melvinsdottir, Menon, Midgett, Mu, Nasuti, Norris, Norris, Norris, Oosthoek, Peacock, Pexieder, Plageman, Rugonyi, Sauls, Sedmera, Seguela, Shelton, Shelton, Shi, Shimazaki, Siobhan Loughna, Snarr, Somi, Steed, Sun, Tobita, Vermot, Villegas Garcia, Wang, Wang, Webb, Wirrig, Wunsch, Yamagishi, Yin, Zanin, Zhang   +88 more
core   +1 more source

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus

Arthritis Research & Therapy
Background Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE.
Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo, Junming Li   +6 more
doaj   +1 more source

Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells

Biochemistry and Biophysics Reports, 2021
Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells.
Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura   +5 more
doaj   +1 more source

Cx3cr1-deficient microglia exhibit a premature aging transcriptome. [PDF]

, 2019
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood.
Allaire, Norm, Burkly, Linda, Challa, Ravi, Cotleur, Anne C, Cullen, Patrick, Glass, Christopher K, Gosselin, David, Gyoneva, Stefka, Hosur, Raghavendra, Miao, Kelly, Ouyang, Zhengyu, Peterson, Michael, Ransohoff, Richard M, Reynolds, Taylor L, Roberts, Chris, Zhang, Baohong   +15 more
core  

Role of KLF2 in endocardial cushion development in mice

The FASEB Journal, 2010
Krüppel‐like factor 2 (KLF2) belongs to a family of transcription factors that have 3 C2/H2 zinc finger domains. KLF2 is expressed in endothelial cells and is induced by shear stress. KLF2−/− embryos in FVB/N genetic background die by embryonic day 11.5 (E11.5) (chi‐square p = 0.0044), whereas in mixed genetic ...
Jack L Haar, Aditi R Chiplunkar, Tina K Lung, Joyce A Lloyd   +3 more
openaire   +1 more source

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

Protein & Cell, 2020
Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by ...
Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, Ying Cao, Ruilin Zhang   +7 more
doaj   +1 more source

Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii [PDF]

, 2012
Background The gastrula stage represents the point in development at which the three primary germ layers diverge. At this point the gene regulatory networks that specify the germ layers are established and the genes that define the differentiated states ...
Garey, James R., Garnhart, Nancy, Livingston, Brian T., Thomas, W. Kelley, Vaughn, Roy   +4 more
core   +2 more sources

Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundCardiovascular disease is the leading cause of morbidity and mortality in patients with end‐stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated ...
Keith Saum, Begoña Campos, Diego Celdran‐Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy‐Chaudhury, A. Phillip Owens   +7 more
doaj   +1 more source

HBV messing with the B-cell genome leads to DLBCL [PDF]

, 2018
non ...
Casato, Milvia, Visentini, Marcella
core   +1 more source