Results 81 to 90 of about 12,659 (217)
Developmental Dynamics, EarlyView.Development and differentiation of the atrial myocardium. Hemodynamic loading triggers shear stress response, which is essential for pectinate muscle formation; mechanical stretching is important for the expression of chamber myocardium markers and proper maturation of the atrial contractile and conductive properties.
C. Neradilova +7 more
wiley +1 more source
Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy
Equine Veterinary Journal, EarlyView.Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan +4 more
wiley +1 more source
The Role of the Transcription Factor KLF2 in Vascular Development and Disease
, 2014 The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of ...
Novodvorsky, P., Chico, T.J.A.
openaire +3 more sources
Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1 [PDF]
Molecular Immunology, 2008 We have shown previously that dipeptidyl peptidase 2 (DPP2) activity is essential for the survival of quiescent, but not activated, lymphocytes. The specific requirement of DPP2 activity for non-dividing cells is indicative of cell cycle specific regulation of this gene product.
Pradeep, Bista +3 more
openaire +2 more sources
MEFs lacking MED23 show altered Klf2 expression.
, 2014 A, Klf2 mRNA expression by qRT-PCR in Med23+/+ (WT) and Med23Δflox/Δflox (MED23 null) MEFs treated with Cre adenovirus, then three days later starved overnight and treated with serum for 1 hour.
Tomofusa Fukuyama (495453) +2 more
core +1 more source
Cancer Management and Research, 2020 Weibin Lian,1,* Xiaohua Jiang,2,* Liangqiang Li,1,* Qinglan Wang,1 Chengye Hong,1 Peidong Yang,1 Debo Chen1 1Department of Breast Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, People’s Republic of China;
Lian W +6 more
doaj
Exploration, EarlyView.Osteoarthritis pain arises not only from joint damage but also from inflammation, abnormal bone changes, and excessive nerve activation inside the joint. In this study, we developed an injectable nanomedicine, LAC, that responds to the acidic environment of osteoarthritic joints to locally release two approved drugs, reducing inflammation, limiting ...
Junyan Liu +12 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang +8 more
wiley +1 more source
IL-6 and IL-8 content of KLF2-transduced BOECs.
, 2012 (A) Immunofluorescence image showing co-localization of IL-6 (green) and VWF (red) in IL-1β-treated KLF2- and mock-transduced BOECs. Nuclei were visualized with DAPI (blue). Scale bars: 10 µm.
Ruben Bierings (159083) +6 more
core +1 more source
Analysis of Mouse EKLF/KLF2 E9.5 Double Knockout: Yolk Sac Morphology and Embryonic Erythroid Maturation [PDF]
, 2007 Krüppel-like factors (KLFs) are a family of transcription factors with 3 Cys2/His2 zinc fingers that regulate cell differentiation and developmental processes.
Lung, Tina Kathy
core +1 more source