Results 71 to 80 of about 11,628 (203)

Effect of KLF2 “Knockdown” on Endothelial Gene Expression.

, 2013
After being transfected for 24 hours, HUVECs were treated with rapamycin at the concentration of 200 ng/ml for 24 hours. HUVECs were transfected with nonspecific siRNA (control siRNA) or specific siRNA (KLF2 siRNA) for 48 hours.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

Multiple myeloma: A tale of deregulated transcription factors

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte, Edurne San José‐Enériz, Estíbaliz Urizar‐Compains, Paula Rodriguez‐Otero, Felipe Prósper, Xabier Agirre   +5 more
wiley   +1 more source

Effect of KLF2 “Knockdown” on Endothelial Gene Expression with thrombin.

, 2013
After being transfected for 20 hours, HUVECs were stimulated with thrombin for 4 hours, and treated with rapamycin at the concentration of 200 ng/ml for 24 hours.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus

Arthritis Research & Therapy
Background Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE.
Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo, Junming Li   +6 more
doaj   +1 more source

Comprehensive analysis of KLF2 as a prognostic biomarker associated with fibrosis and immune infiltration in advanced hepatocellular carcinoma

BMC Bioinformatics, 2023
Purpose Most Hepatocellular carcinoma (HCC) patients are in advanced or metastatic stage at the time of diagnosis. Prognosis for advanced HCC patients is dismal.
Xue-Qin Chen, Jie Ma, Di Xu, Zuo-Lin Xiang   +3 more
doaj   +1 more source

Role of KLF2 in endocardial cushion development in mice

The FASEB Journal, 2010
Krüppel‐like factor 2 (KLF2) belongs to a family of transcription factors that have 3 C2/H2 zinc finger domains. KLF2 is expressed in endothelial cells and is induced by shear stress. KLF2−/− embryos in FVB/N genetic background die by embryonic day 11.5 (E11.5) (chi‐square p = 0.0044), whereas in mixed genetic ...
Jack L Haar, Aditi R Chiplunkar, Tina K Lung, Joyce A Lloyd   +3 more
openaire   +1 more source

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

Protein & Cell, 2020
Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by ...
Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, Ying Cao, Ruilin Zhang   +7 more
doaj   +1 more source

Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells

Biochemistry and Biophysics Reports, 2021
Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells.
Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura   +5 more
doaj   +1 more source

Immune Dysregulation in Branched Chain Organic Acidemias

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Organic acidemias (OAs) are a group of inherited disorders, most commonly caused by defects in mitochondrial enzymes involved in amino acid and fatty acid metabolism. While they characteristically present with metabolic and neurological crises, growing evidence reveals a significant burden of chronic immune dysregulation in some disorders and ...
Abdul L. Shakerdi, Jack Drda, Justin A. Dutta, Jerry Vockley   +3 more
wiley   +1 more source

Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundCardiovascular disease is the leading cause of morbidity and mortality in patients with end‐stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated ...
Keith Saum, Begoña Campos, Diego Celdran‐Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy‐Chaudhury, A. Phillip Owens   +7 more
doaj   +1 more source