Results 71 to 80 of about 12,659 (217)

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

Protein & Cell, 2020
Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by ...
Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, Ying Cao, Ruilin Zhang   +7 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Effect of KLF2 “Knockdown” on Endothelial Gene Expression with thrombin.

, 2013
After being transfected for 20 hours, HUVECs were stimulated with thrombin for 4 hours, and treated with rapamycin at the concentration of 200 ng/ml for 24 hours.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Effect of KLF2 “Knockdown” on Endothelial Gene Expression.

, 2013
After being transfected for 24 hours, HUVECs were treated with rapamycin at the concentration of 200 ng/ml for 24 hours. HUVECs were transfected with nonspecific siRNA (control siRNA) or specific siRNA (KLF2 siRNA) for 48 hours.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

Comprehensive analysis of KLF2 as a prognostic biomarker associated with fibrosis and immune infiltration in advanced hepatocellular carcinoma

BMC Bioinformatics, 2023
Purpose Most Hepatocellular carcinoma (HCC) patients are in advanced or metastatic stage at the time of diagnosis. Prognosis for advanced HCC patients is dismal.
Xue-Qin Chen, Jie Ma, Di Xu, Zuo-Lin Xiang   +3 more
doaj   +1 more source

Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells

Biochemistry and Biophysics Reports, 2021
Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells.
Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura   +5 more
doaj   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundCardiovascular disease is the leading cause of morbidity and mortality in patients with end‐stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated ...
Keith Saum, Begoña Campos, Diego Celdran‐Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy‐Chaudhury, A. Phillip Owens   +7 more
doaj   +1 more source

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source