Kaohsiung Journal of Medical Sciences, 2022 Oral squamous cell carcinoma (OSCC) is one of the most common carcinomas of the oral cavity. However, the regulatory mechanisms on miR‐32‐5p remain poorly understood in OSCC.
Shi‐Yu Qin +5 more
doaj +1 more source
Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]
, 2017 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A +3 more
core +1 more source
The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies. [PDF]
PLoS ONE, 2012 BACKGROUND: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear.
Ellen L van Agtmaal +6 more
doaj +1 more source
New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]
, 2013 Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien +3 more
core +1 more source
9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons) [PDF]
, 2009 The KIX-domain of Gal11/MED15 was shown to interact with short transactivation domain of Pdr1 and Oaf1 (12 and 9 amino acids respectively) annotated to 9aaTAD family.
martin piskacek
core +2 more sources
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension [PDF]
Nature Communications, 2020 Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH.
Hebah A. Sindi +17 more
openaire +9 more sources
KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2
American Journal of Men's Health, 2019 KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown.
Binshuai Wang +5 more
doaj +1 more source
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis [PDF]
, 2011 Background Nerve growth factor (NGF) is a potent growth factor that plays a key role in neuronal cell differentiation and may also play a role in hematopoietic differentiation.
Priyanka Dutta +6 more
core +1 more source
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival [PDF]
Nature Communications, 2016 AbstractKDM3A is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been elucidated. Here we identify KDM3A–KLF2–IRF4 axis dependence in MM. Knockdown of KDM3A is toxic to MM cells in vitro and in vivo. KDM3A maintains expression of KLF2 and IRF4 through H3K9 demethylation, and knockdown of KLF2 triggers ...
Hiroto Ohguchi +17 more
openaire +4 more sources
European Journal of Inflammation, 2020 Kruppel-like factor 2 (KLF2) is associated with acute and chronic inflammation. However, the role of KLF2 in rheumatoid arthritis (RA) remains unknown.
Donglei Wu +7 more
doaj +1 more source