Results 51 to 60 of about 12,659 (217)

Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36

Journal of Lipid Research, 2014
The Krppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, apoptosis, development, and responses to external stress.
Jin-Lian Chen, Xiao-Jie Lu, Kai-Lin Zou, Kun Ye   +3 more
doaj   +1 more source

Role of KLF2 in atrioventricular cushion development

The FASEB Journal, 2009
Krüppel like factors (KLFs) are transcription factors with important roles in development. KLF2 KO mice die by embryonic day 14.5 (E14.5) and exhibit heart failure and hemorrhaging. KLF2 is expressed in multiple tissues including erythroid and endothelial cells.
Jack L. Haar, Tina K. Lung, Aditi R. Chiplunkar, Joyce A. Lloyd   +3 more
openaire   +1 more source

Expression of KLF2 in BOECs.

, 2012
(A) Immunofluorescent analysis of mock- and KLF2-transduced BOECs. Cells were immunostained for CD31 (red) and KLF2 (green); nuclei were stained using DAPI (blue).
Ruben Bierings (159083), Bieuwke S. Dragt (159089), Ellen L. van Agtmaal (159077), Jan Voorberg (159111), Mar Fernandez-Borja (159099), Anton J. G. Horrevoets (159105), Thomas A. Leyen (159093)   +6 more
core   +1 more source

Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism

Frontiers in Immunology, 2023
AimsExpanded hemodialysis (HDx) therapy with improved molecular cut-off dialyzers exerts beneficial effects on lowering uremia-associated chronic systemic microinflammation, a driver of endothelial dysfunction and cardiovascular disease (CVD) in ...
Hongfan Zhao, Dashan Wu, Michael Adu Gyamfi, Pinchao Wang, Christian Luecht, Anna Maria Pfefferkorn, Muhammad Imtiaz Ashraf, Julian Kamhieh-Milz, Janusz Witowski, Duska Dragun, Klemens Budde, Ralf Schindler, Daniel Zickler, Guido Moll, Guido Moll, Rusan Catar   +15 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival [PDF]

Nature Communications, 2016
AbstractKDM3A is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been elucidated. Here we identify KDM3A–KLF2–IRF4 axis dependence in MM. Knockdown of KDM3A is toxic to MM cells in vitro and in vivo. KDM3A maintains expression of KLF2 and IRF4 through H3K9 demethylation, and knockdown of KLF2 triggers ...
Hiroto Ohguchi, Teru Hideshima, Manoj K. Bhasin, Gullu T. Gorgun, Loredana Santo, Michele Cea, Mehmet K. Samur, Naoya Mimura, Rikio Suzuki, Yu-Tzu Tai, Ruben D. Carrasco, Noopur Raje, Paul G. Richardson, Nikhil C. Munshi, Hideo Harigae, Takaomi Sanda, Juro Sakai, Kenneth C. Anderson   +17 more
openaire   +4 more sources

Low KLF2 expression can control trafficking molecules but high KLF2 expression is required to inhibit proliferation.

, 2013
(A) Data show the gating strategy used to identify populations with differential KLF2 expression in GFP-KLF2 transduced activated CD8 T cells. For all experiments P14 CD8 T cells were activated for with gp33-41 peptide and retroviral transduction was ...
Carmen Feijoo-Carnero (470537), Nick Schurch (470538), Victoria H. Cowling (260831), Doreen A. Cantrell (470539), Gavin C. Preston (470536)   +4 more
core   +1 more source

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +1 more source

Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo. [PDF]

PLoS ONE, 2015
The flow-responsive transcription factor Krüppel-like factor 2 (KLF2) maintains an anti-coagulant, anti-inflammatory endothelium with sufficient nitric oxide (NO)-bioavailability.
Ruud D Fontijn, Oscar L Volger, Tineke C van der Pouw-Kraan, Anuradha Doddaballapur, Thomas Leyen, Josefien M Baggen, Reinier A Boon, Anton J G Horrevoets   +7 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source