Results 91 to 100 of about 17,085 (238)

The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate

Biomarker Research
Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner.
Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He, Zunmin Zhu   +6 more
doaj   +1 more source

IRF4 in multiple myeloma—biology, disease and therapeutic target [PDF]

, 2018
Multiple Myeloma (MM) is an incurable hematologic malignancy characterized by abnormal proliferation of plasma cells. Interferon Regulatory Factor 4 (IRF4), a member of the interferon regulatory family of transcription factors, is central to the genesis ...
Abruzzese, Agirre, Alessandro Agnarelli, Alinikula, Alzrigat, Alzrigat, Bai, Basso, Basso, Bat-Erdene, Bhagwat, Bollati, Botta, Brass, Brass, Bravo, Calado, Chaidos, Chapman, Conery, Decker, Delmore, Dominguez-Sola, Erika J. Mancini, Escalante, Fionda, Gass, Ghurye, Gonda, Gyory, Hanbali, Heuck, Hideshima, Holien, Houde, Huang, Huang, Hung, Iida, Jourdan, Klein, Kronke, Kumar, Lasko, Leung-Hagesteijn, Li, Lin, Lin, Lin, Lin, Lohr, Lopez-Girona, Lu, Martin, Mertz, Mimura, Mittrucker, Morelli, Muramatsu, Naymagon, Nutt, Ocana, Ochiai, Ochiai, Ohguchi, Papavassiliou, Perez-Salvia, Qin, Rajkumar, Rajkumar, Rajkumar, Reimold, Remesh, Saito, Salhia, Schebesta, Sciammas, Sciammas, Shaffer, Shaffer, Shlomchik, Siegel, Sive, Tahara, Takahasi, Tang, Tatetsu, Tellier, Tim Chevassut, Tussiwand, Ueno, Wadhwa, Walker, Wang, Willis, Winkelmann, Yamane, Yoshida, Zhu   +98 more
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Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants [PDF]

, 2019
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs
AC Fahed, AC Michell, B Bamforth, B Li, B Xu, BG Bruneau, C-M Chen, CA Eisenberg, D Fraidenraich, D Sabour, ED Cohen, EY Chen, H Mori, H Thomas, I Pacheco-Leyva, J Bakkers, JA Bisson, JA Gaspar, JP Pinto, JPM Barbera, K Meganathan, KR Kranc, M Sahara, M Xu, MV Kuleshov, P Andre, P Choudhry, P Hu, Q Li, S Bhattacharya, S Liu, S Mazzotta, S Sperling, S Ueno, S Zaidi, S-W Cha, SD Bamforth, ST MacDonald, ST MacDonald, T Tan, V Kouskoff, V Wagh, VK Khodiyar, WJ Weninger, Y Liu, Z Yin   +45 more
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Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER⁺ breast tumors. [PDF]

, 2013
MEF2s transcription factors and class IIa HDACs compose a fundamental axis for several differentiation pathways. Functional relationships between this axis and cancer are largely unexplored.
Brancolini, C., Clocchiatti, A, Di Giorgio, E, Ingrao, S, Meyer-Almes, FJ, Tripodo, C   +5 more
core   +1 more source

Neutrophil KLF2 Regulates Arterial and Venous Thrombosis

Blood, 2018
Abstract Experimental, clinical and pathological studies support an important link between inflammation and thrombosis. Although accumulating evidence suggests that cells of the innate immune system contribute to the thrombotic process, the identity of nodal molecular determinants operative in immune cells remains poorly understood.
Lalitha V. Nayak, Stephanie Lapping, Andrei Maiseyeu, Alvin H. Schmaier, Mukesh Jain   +4 more
openaire   +1 more source

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]

, 2015
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine, Gray, Nathanael S, Hellman, Judith, Khakpour, Samira, Prakash, Arun, Sundar, Shirin, Tran, Alphonso, Wang, Jinhua, Wilhelmsen, Kevin, Xu, Fengyun   +9 more
core   +1 more source

Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression

Cancer Management and Research, 2020
Weibin Lian,1,* Xiaohua Jiang,2,* Liangqiang Li,1,* Qinglan Wang,1 Chengye Hong,1 Peidong Yang,1 Debo Chen1 1Department of Breast Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, People’s Republic of China;
Lian W, Jiang X, Li L, Wang Q, Hong C, Yang P, Chen D   +6 more
doaj  

The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway

Journal of Lipid Research
Liver steatosis is a common metabolic disorder resulting from imbalanced lipid metabolism, which involves various processes such as de novo lipogenesis, fatty acid uptake, fatty acid oxidation, and VLDL secretion.
Yuhong Huang, Yi Fan Wang, Xiong Zhong Ruan, Chi Wai Lau, Li Wang, Yu Huang   +5 more
doaj   +1 more source

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +2 more sources

Transcriptional regulation of endothelial KLF2 in vascular development

, 2022
The development of a functional vascular system is critically dependent on shear stress, a hemodynamic force exerted onto the vascular endothelium by flowing blood. Krüppel-like factor 2 (KLF2) is the central transcriptional regulator of the endothelial shear stress response, yet the mechanisms by which shear stress signalling controls KLF2 expression ...
openaire   +1 more source