Results 91 to 100 of about 12,659 (217)

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

KLF2 binding to the AQP1 promoter.

, 2016
HUVECs were transduced with control virus (white) or lentivirus encoding V5-tagged KLF2 (black). Immunoprecipitation was performed using an anti-V5 tag antibody.
Ruud D. Fontijn (725564), Oscar L. Volger (804629), Anuradha Doddaballapur (840992), Thomas Leyen (840993), Josefien M. Baggen (725563), Tineke C. van der Pouw-Kraan (840991), Anton J. G. Horrevoets (159105), Reinier A. Boon (840994)   +7 more
core   +1 more source

A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade

Journal of Orthopaedic Surgery and Research
Background Multiple myeloma (MM) is a malignant disorder originating from plasma cells. Bortezomib (BTZ) resistance has become a huge obstacle to MM treatment.
Ziyi Liu, Xiaoliang Li, Yin He, Fengqun Xie, Yanrong Zhang, Mufang Huang, Yinjingwen Wang, Weijian Zhu   +7 more
doaj   +1 more source

Survival after first relapse in marginal zone lymphomas: Prospective data from the international observational NF10 study

British Journal of Haematology, EarlyView.
Summary While marginal zone lymphoma (MZL) is generally indolent, outcomes following relapse remain poorly defined. This study utilized the indolent Non Follicular 10 (NF10) prospective database to characterize survival and identify prognostic drivers in patients failing initial systemic therapy. The study analysed 122 patients with relapsed MZL.
Stefano Luminari, Maria Elena Nizzoli, Michele Merli, Sara Rattotti, Vittoria Tarantino, Simone Ferrero, Annalisa Talami, Roberta Murru, Marina Deodato, Emanuele Cencini, Giovanni Roti, Carlo Visco, Guilherme Duffles, Michele Spina, Ombretta Annibali, Alessandro Pulsoni, Andrés José María Ferreri, Caterina Stelitano, Elsa Pennese, Emiliano Barbieri, Marzia Varettoni, Gambara Silvia, Marta Coscia, Dario Marino, Tisi Maria Chiara, Maher Nawar, Luigi Marcheselli, Francesco Merli, Luca Arcaini   +28 more
wiley   +1 more source

Role of KLF2 in endocardial cushion development in mice

The FASEB Journal, 2010
Krüppel‐like factor 2 (KLF2) belongs to a family of transcription factors that have 3 C2/H2 zinc finger domains. KLF2 is expressed in endothelial cells and is induced by shear stress. KLF2−/− embryos in FVB/N genetic background die by embryonic day 11.5 (E11.5) (chi‐square p = 0.0044), whereas in mixed genetic ...
Jack L Haar, Aditi R Chiplunkar, Tina K Lung, Joyce A Lloyd   +3 more
openaire   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Cord Blood‐Derived Fibroblast Activation Protein‐Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo

Cancer Science, EarlyView.
We generated cord blood‐derived FAP‐targeted CAR NK cells and evaluated their activity against cancer‐associated fibroblasts. These cells showed antigen‐specific cytotoxicity in vitro and robust persistence in a pleural dissemination model, although in vivo anti‐CAF efficacy was limited, supporting further development of stromal‐targeted cellular ...
Takashi Hiroshima, Toru Kimura, Mariko Maekawa, Mayuko Noguchi, Takahiro Matsui, Shunya Ikeda, Makiko Suga, Hideki Nagata, Kenji Kimura, Eriko Fukui, Takashi Kanou, Naoko Ose, Eiichi Morii, Yasushi Shintani, Naoki Hosen   +14 more
wiley   +1 more source

Neutrophil KLF2 Regulates Arterial and Venous Thrombosis

Blood, 2018
Abstract Experimental, clinical and pathological studies support an important link between inflammation and thrombosis. Although accumulating evidence suggests that cells of the innate immune system contribute to the thrombotic process, the identity of nodal molecular determinants operative in immune cells remains poorly understood.
Lalitha V. Nayak, Stephanie Lapping, Andrei Maiseyeu, Alvin H. Schmaier, Mukesh Jain   +4 more
openaire   +1 more source

The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate

Biomarker Research
Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner.
Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He, Zunmin Zhu   +6 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source