Results 111 to 120 of about 11,628 (203)
Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation
, 2022 Krüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription factor that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties.
Shunwang Li +33 more
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Rapamycin regulated the activity of KLF2 in HUVECs with thrombin.
, 2013 A, After stimulation with thrombin for 4 hours, rapamycin was added to HUVECs at the concentration of 200 ng/ml for 2, 4, 8, 12, 24 and 48 hours. The activity of KLF2 was assessed by EMSA.
Qian Ma (69668) +6 more
core +1 more source
, 2022 KLF2 is an important transcription factor for maintaining vascular homeostasis. Its expression in endothelial cells is triggered by shear stress. The endothelial glycocalyx also plays a role in regulating vascular function, and prior work has shown that ...
O\u27Grady, Cambria
core +1 more source
Kruppel-Like Factor 2 Regulates Dendritic Cell Activation in Patients with Acute Coronary Syndrome
Cellular Physiology and Biochemistry, 2013 Objective: Dendritic cells (DCs) activation is important in atherosclerosis and coronary heart disease, but the mechanisms regulating activation of dendritic cells remain largely unclear.
Hongcheng Fang +11 more
doaj +1 more source
Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response
Cell Structure and FunctionThe Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi.
Kanae Sasaki +11 more
doaj +1 more source
eLife, 2018 Complex interplay between cardiac tissues is crucial for their integrity. The flow responsive transcription factor KLF2, which is expressed in the endocardium, is vital for cardiovascular development but its exact role remains to be defined. To this end,
Seyed Javad Rasouli +7 more
doaj +1 more source
, 2007 Krüppel-like factors (KLFs) are a family of transcription factors with 3 Cys2/His2 zinc fingers that regulate cell differentiation and developmental processes.
Lung, Tina Kathy
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Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis
Nature Cardiovascular ResearchAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Laminar shear stress from blood flow, sensed by vascular endothelial cells, protects from ASCVD by upregulating the transcription factors KLF2 and KLF4, which induces an anti-inflammatory program that promotes vascular resilience.
Divyesh Joshi +14 more
openaire +2 more sources
Delineation of the domains of Klf2 required for the self-renewal of mouse ES cells.
, 2016 (A) Schematic illustration of Klf2 deletion (Δ) mutants. Klf2 is highly homologous to Klf4 and belongs to the same subclass. A FLAG-HA tandem epitope tag was fused to the N-terminus of each of the deletion mutants.
Jun Yanagisawa (2550943) +6 more
core +1 more source