Results 111 to 120 of about 12,659 (217)

Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3

, 2015
Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known.
Boon, R.A., Lucas, T., Potente, M., Chen, W., Doddaballapur, A., You, X., Michalik, K.M., Manavski, Y., Zeiher, A.M., Dimmeler, S., Houtkooper, R.H.   +10 more
core   +1 more source

Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice

, 2023
Diabetic endothelial dysfunction associated with diminished endothelial nitric oxide synthase (eNOS) activity accelerates the development of atherosclerosis and cardiomyopathy.
Chi Wai Lau (108714), Yang Zhang (30734), Jiang-Yun Luo (12078698), Alex F. Chen (115178), Chak Kwong Cheng (16407939), Aimin Xu (120142), Yu Huang (15093), Lei He (143930), Lei Zhao (144153), Lingshan Gou (9321116), Li Wang (15202)   +10 more
core   +1 more source

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

Initial OX40–OX40L Signaling Promotes a Skin‐Resident Memory T‐Cell Reservoir in Atopic Dermatitis

Allergy, EarlyView.
Takayoshi Komatsu‐Fujii, Ryota Asahina, Tatsuya Hasegawa, Satoshi Nakamizo, Saeko Nakajima, Toshiaki Kogame, Kenji Kabashima   +6 more
wiley   +1 more source

CO‐Rebreathing in Essential Thrombocythemia and Polycythemia Vera. A Revival of an Old Methodology to Improve Diagnosis and Phlebotomy Decisions

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT The diagnostic landscape for the Philadelphia‐negative myeloproliferative neoplasms (MPNs), particularly in distinguishing Essential Thrombocythemia (ET) from Polycythemia Vera (PV), is compromised. The gold standard for diagnosing PV—measurement of red cell mass (RCM) by radioisotope dilution—has been largely abandoned, leading to widespread ...
Hans C. Hasselbalch, Morten Kranker Larsen, Lea Løffler, Camilla Andersen, Isabella Davidsen, Mette Grymer Jensen, Jonas Bechlund, Lasse Kjær, Vibe Skov, Henning Bay Nielsen, Carsten Lundby   +10 more
wiley   +1 more source

Rapamycin regulated the activity of KLF2 in HUVECs with thrombin.

, 2013
A, After stimulation with thrombin for 4 hours, rapamycin was added to HUVECs at the concentration of 200 ng/ml for 2, 4, 8, 12, 24 and 48 hours. The activity of KLF2 was assessed by EMSA.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

Electron microscopy of E9.5 FVB/N KLF2−/− atrioventricular cushions shows abnormal endocardial cell morphology.

, 2013
In WT (A), the endocardium is one cell-layer thick but in KLF2−/− (B), there are multiple disorganized cell layers. The boxes enclose the AV canal. At higher magnification, endocardial cells in KLF2 KO (D) extend cytoplasmic projections or filopodia-like
Joyce A. Lloyd (282148), Yousef Alhashem (282143), Jack L. Haar (282147), Rakesh C. Kukreja (282146), Tina K. Lung (282142), Fadi N. Salloum (282145), Benjamin A. Koppenhaver (282144), Aditi R. Chiplunkar (282141)   +7 more
core   +1 more source

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

Cell Structure and Function
The Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi.
Kanae Sasaki, Reishi Tanaka, Iona Miyake, Miyu Sakamoto, Ryuya Tanaka, Azusa Tanaka, Misaki Terami, Ryota Komori, Mai Taniguchi, Sadao Wakabayashi, Hajime Tajima Sakurai, Hiderou Yoshida   +11 more
doaj   +1 more source

Kruppel-Like Factor 2 Regulates Dendritic Cell Activation in Patients with Acute Coronary Syndrome

Cellular Physiology and Biochemistry, 2013
Objective: Dendritic cells (DCs) activation is important in atherosclerosis and coronary heart disease, but the mechanisms regulating activation of dendritic cells remain largely unclear.
Hongcheng Fang, Jing Lin, Lei Wang, Peiyi Xie, Xiaoyan Wang, Jianyun Fu, Wen Ai, Shaoyuan Chen, Fei Chen, Fengxiao Zhang, Yousu Su, Dazhu Li   +11 more
doaj   +1 more source