Results 121 to 130 of about 11,628 (203)

KLF2 keeps B cells in their place [PDF]

Nature Reviews Immunology, 2010
openaire   +2 more sources

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization

, 2006
OBJECTIVE: The transcription factor KLF2 is considered an important mediator of the anti-inflammatory and anti-thrombotic properties of the endothelium. KLF2 is absent from low-shear, atherosclerosis-prone sites of the vascular tree but is induced by HMG-
Pannekoek, Hans, Rohlena, Jakub, Kootstra, Neeltje A., Dekker, Rob J., Fledderus, Joost O., van IJzendoorn, Gerben A., van Thienen, Johannes V., Horrevoets, Anton J. G.   +7 more
core   +1 more source

KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1

iScience
Summary: Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive.
Wei Chen, Yinghong Cui, Chunyun Li, Caimei He, Li Du, Wei Liu, Zuping He   +6 more
doaj   +1 more source

Rapamycin induced mRNA and protein expression of KLF2 in HUVECs with thrombin.

, 2013
After stimulation with thrombin for 4 hours, rapamycin was added to HUVECs at concentrations of 2, 20, 200 and 2000 ng/ml for 24 and 48 hours. KLF2 was assessed by real-time PCR, western blot and immunofluorescence assays.
Qian Ma (69668), Shiwei Yang (310216), Yujie Zhou (310222), Dean Jia (310219), Xiaomin Nie (310212), Miao Yu (199182), Zhijian Wang (310214)   +6 more
core   +1 more source

KLF2 wt Allele [PDF]

, 2020
openaire   +1 more source

Resveratrol protects against uremic serum-induced endothelial cell injury by activating the FUS/KLF2/FBXW7 signaling pathway

Applied Biological Chemistry
Background Chronic kidney disease causes endothelial cell dysfunction associated with uremia, which triggers a high risk of cardiovascular diseases. Furthermore, prolonged exposure of the vascular endothelium to uremic toxins could provoke endothelial ...
Danjun Wang, Jianlian Liu, Juan Wang, Yang Feng   +3 more
doaj   +1 more source

KLF2/KLF4 Double Knock-out Mouse Embryos Show Cranial Bleeding with Endothelial Disruption of the Primary Head Vein

, 2010
Krüppel-like factors (KLFs) are a family of 3 Cys2/His2 zinc finger transcription factors with a diverse set of roles in cellular differentiation, cell cycle regulation, tumor suppression, erythropoiesis, angiogenesis, and other processes.
Curtis, Benjamin
core   +2 more sources

KLF2 determines the susceptibility of T cells to immunoregulatory NK cells.

Abstract Natural killer (NK) cells suppress cellular and humoral immune responses via killing of T cells, resulting in diminished vaccine responses in mice and humans. Efforts to overcome this roadblock and achieve optimal immunity require an improved understanding of the molecular mediators facilitating NK cell-targeting of discrete subsets of
Stephen Waggoner, Andrew Cox, Laura Canaday, Alexander Katko, Harrison Feldman, Kathrynne Warrick, Anastassia Tselikova, Harsha Seelamneni, Krishna Roskin   +8 more
openaire   +2 more sources

Regulation of endothelial metabolism by laminar shear stress and flow-induced transcription factor KLF2

, 2016
Flow hemodynamics regulates endothelial cell (EC) responses and laminar shear stress induces an atheroprotective and quiescent phenotype. The flow-responsive transcription factor KLF2 is a pivotal mediator of endothelial quiescence, but the precise ...
Doddaballapur, Anuradha
core  

KLF2's role in T cell trafficking and retention in lymphoid and non-lymphoid tissues

, 2013
University of Minnesota Ph.D. dissertation. July 2013. Major: Microbiology, Immunology and Cancer Biology. Advisor: Stephen C. Jameson, PhD. 1 computer file (PDF); vii, 146 pages.The transcription factor Kruppel-like Factor 2 (KLF2) is essential for ...
Skon, Cara Noelle
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