Beyond Exhaustion: The RNA Regulatory Layer of Tissue‐Instructed T Cell Dysfunction
European Journal of Immunology, Volume 56, Issue 10, October 2026.CD8+ T cell dysfunction arises through classical exhaustion after priming by professional antigen‐presenting cells, and through extra‐lymphoid priming by non‐professional cells – exemplified by the liver, where hepatocyte priming yields a checkpoint‐refractory state.
Francesco Andreata +3 more
wiley +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
MedComm, Volume 7, Issue 10, October 2026.Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment
MedComm, Volume 7, Issue 10, October 2026.The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan +10 more
wiley +1 more source
Tiao jie gan zang he pu tao tang dai xie de gan zang KLF2
, 2017 Ph.D.Kruppel样因子2（KLF2）属于Kruppel样因子（KLFs）家族。它在许多生物化学过程中起重要作用，例如肺发育，胚胎红细胞生成，上皮完整性，T细胞活力和脂肪形成。KLF2可通过负调控脂肪组织中的PPARγ来抑制脂肪形成。脂肪代谢在肝脏也有重要作用，而KLF2在肝脏的作用报道很少。仅有一篇文章报道肝脏KLF2在非酒精性脂肪性肝病（NAFLD）中促进肝脏脂肪变性。目前还没有关于KLF2和葡萄糖代谢之间的关系的报道。由于NAFLD与胰岛素抵抗和II型糖尿病密切相关 ...
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E10.5 FVB/N KLF2−/− but not mix KLF2−/− embryos have erythroid cells outside of the dorsal aortas.
, 2013 (A) is a light micrograph (100X) of the FVB/N WT E10.5 dorsal aortas (DA). Erythroid cells (Ery) are found only within the aortas. (B) FVB/N KLF2−/− have a number of erythroid cells in tissue surrounding the DA.
Joyce A. Lloyd (282148) +7 more
core +1 more source
Enforced KLF2 expression blocks the activation of LPS-stimulated primary splenic B cells.
, 2014 (A, B) PCR analyses of cell cycle and apoptotic regulators in LPS-stimulated, control- and KLF2-infected, GFP+-sorted splenic B cells with transcript specific primers 48 h after infection. HPRT signals control the integrity and amount of cDNA. (A) Serial
Hans-Martin Jäck (122662) +4 more
core +1 more source
, 2010 The transcription factor Krüppel-like factor 2 (KLF2) is critical for normal trafficking of T lymphocytes, but its role in B cells is unclear.
Xiaodan Wang +3 more
core +1 more source
KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy
, 2019 Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation.
Dipranjan Laha (6491537) +2 more
core +1 more source
KLF2's role in T cell trafficking and retention in lymphoid and non-lymphoid tissues
, 2013 University of Minnesota Ph.D. dissertation. July 2013. Major: Microbiology, Immunology and Cancer Biology. Advisor: Stephen C. Jameson, PhD. 1 computer file (PDF); vii, 146 pages.The transcription factor Kruppel-like Factor 2 (KLF2) is essential for ...
Skon, Cara Noelle
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ROLES OF KRÜPPEL LIKE FACTORS KLF1, KLF2, AND KLF4 IN EMBRYONIC BETA-GLOBIN GENE EXPRESSION
, 2009 Krüppel like factors (KLFs) are a family of 17 proteins whose main function is gene regulation by binding to DNA elements in the promoters of various genes.
Alhashem, Yousef
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